| 1. |  Fer0m0nas | 103,105 | Uma Grama de Queijo! - The Binding of Isaac | 16:07 |
| 2. | DDM | 1,720 | Let's Play Binding Of Isaac Wrath Of The Lamb Finale - I NEED KEYS | 28:51 |
| 3. | djmacgameplay s | 1,593 | The Binding of Isaac - Daily Run 16/02/2023 | 22:24 |
| 4. | Bocherz | 855 | When Life Gives Lives, you should take them, or atleast not be a dumbass #twitch #bindingofisaac | 0:10 |
| 5. | Tiops | 318 | Live no Twitch - Binding of Isaac (18/11/2015) | 1:11:08 |
| 6. | Solaire Gaming | 311 | The Binding of Isaac - Slow Roll Challenge! | 27:44 |
| 7. | Salsa Games | 290 | Quinta-Feira Rogue-Like | 1:47:45 |
| 8. | DIX | 195 | 400 inscritos...obrigado | 5:15 |
| 9. | qvods | 189 | q LOCKS IN and gets some Ws [The Binding of Isaac] | 3:08:50 |
| 10. | Goldfeel Music | 157 | The Binding Of Isaac Soundtrack But With A Pipe Organ #shorts #thebindingofisaac #soundtrack | 0:45 |
| 11. | Melgacius Annoying Accent Reviews | 68 | The Binding of Isaac - Review | 3:31 |
| 12. | Globtwo | 68 | Rivals S02E11 | Lemming Ball Z 3D, Hearthstone, Toybox Turbos, The Binding of Isaac | 20:39 |
| 13. | 2Manos Gamers | 51 | The Binding of Isaac: O jogo mais VICIANTE de SEMPRE! | 11:38 |
| 14. | Kylla's Stream Archive | 34 | There was no tomb after all :( | Tomb Raider I + The Binding of Isaac | 2:14:00 |
| 15. | João Miranda | 34 | YOUTUBEMONS - Pokemon Showdown vs Duztr | 8:26 |
| 16. | psenough | 29 | Binding of Isaac IPECAC mod v1.3 | 0:00 |
| 17. | MrDark236 | 7 | Greed! - The Binding of Issac Afterbirth | 27:47 |
| 18. | kier7kier7 Clips | 5 | THATS WHAT?! | kier7kier7 #shorts | 0:08 |
| 19. | CDKEYPT | 2 | Top 15 Best Pixel Art Games - June 2021 Selection | 5:08 |
| 20. | Mais ARMSMY | 0 | VALORANT #86 | THE BINDING OF ISAAC #2 | 0:00 |
