| 1. |  Bindey | 1,364,605 | Rocket In A Jar Explained - The Binding Of Isaac: Repentance | 3:37 |
| 2. | Luigikid Gaming | 144,368 | SATELITE RUSH - SCI-FI THE BINDING OF ISAAC [KICKSTARTER DEMO] | 10:14 |
| 3. | Christensen | 132,124 | Switch vs. Steam Deck! #nintendo #switch #steamdeck #console #controller #stickdrift #zocken | 0:28 |
| 4. | Himsl Games | 96,770 | Binding of Isaac Explained: Worm Enemies! | 5:46 |
| 5. | Mr.Thomsn | 74,846 | VICTORY LAP MODE | The Binding of Isaac Afterbirth+ | 20:22 |
| 6. | WWEdeadman | 15,109 | That didn't go as expected - The Binding of Isaac: Repentance #93 | 0:00 |
| 7. | Tom Henks | 6,164 | Tom plays Afterbirth - Ep. 1 [A Lost Day] | 0:00 |
| 8. | Videograb | 3,998 | Harry Potter Fail, The Binding of Isaac: Afterbirth #017, Portal 2 #001 [PC] [FullHD] | 3:19:58 |
| 9. | TouchGameplay | 3,502 | The Binding of Isaac Rebirth (by Nicalis, Inc.) - iOS - HD LiveStream | 1:47:46 |
| 10. | orizuru | 2,292 | The Binding of Isaac - Afterbirth+ - The Forgotten vs Blue Baby | 1:07:45 |
| 11. | HofiLP | 2,130 | Das Knive muss ordentlich zustechen! - The Binding of Isaac: Repentance (HofiLP am 06.12.2023) | 1:58:13 |
| 12. | 🩷MewMew🩵 | 452 | The Hard Carry of Isaac | 24:41 |
| 13. | berkus | 416 | Wie lange schaffen wir es mit schlechten Items? | Binding of Isaac: Repentance | 0:00 |
| 14. | Biggy&Stepsi | 390 | The Binding of Isaac 💀 Wir machen ein paar Runs 🔴 Live | 1:21:51 |
| 15. | Zelpnir | 233 | Mein Lieblingsgame - The Binding of Isaac: Rebirth - INDIE FEEDBACK #001 | 3:55 |
| 16. | Muffet | 176 | Test isaac runs | 58:08 |
| 17. | GaryTheGerman-rid | 164 | UnderMine | Das neue Isaac? | Part 1 [German/angezockt] | 43:13 |
| 18. | RKR | 142 | Let's Stream Super Mario Maker 2 (21.4.2024) + The Binding of Isaac Repentance | 3:27:36 |
| 19. | Estrana | 128 | Pillenhafte Beauty Fly | Isaac Afterbirth | Folge 5 | 53:03 |
| 20. | ErkandorLP | 121 | The Binding of Isaac: Repentance: Roguelikes: Wünsch dir was (Vorweihnachtsstream) | 0:00 |
| 21. | headfullasmr | 112 | ASMR The Binding of Isaac Rebirth GERMAN | 16:50 |
| 22. | PKWeegee1337 | 99 | Paper Mario: TTYD - Episode 61 - Cogs of Darkness | 13:55 |
| 23. | geistreiches | 91 | #SPIDERCAM ... The Binding of Isaac [ENG] - STREAM #8 | 1:13:27 |
| 24. | Toparc | 88 | The Best Dungeon Crawler Games On Steam 💟 | 3:16 |
| 25. | Quin69Shorts | 74 | Isaac69 - taking care of little Isaac the quinL way | 7:20 |
| 26. | KaiZar | 49 | BROKEN MODEM ist OP! | 18:40 |
| 27. | HolyFistHD Archiv | 46 | The Binding of Isaac - Afterbirth+ (Switch) #04 - 2017 | 1:03:23 |
| 28. | Nerdy_Emily_ | 35 | (Ger) The Binding of Isaac Afterbirth 4 (PS4 Gameplay) | 40:24 |
| 29. | ThePurpleBlackDragon | 28 | 'RS' Boss Rush Apocalypse -Go for the Head- | 7:38 |
| 30. | Newsroom Fab | 27 | Infos (The Binding Off Isaac News) | 8:27 |
| 31. | Abseudus | 27 | Let's Stream Binding of Isaac + Diskussionsrunde | 1:59:25 |
| 32. | Wyzau | 18 | Robot Legions Reborn Gameplay #1 | 42:46 |
| 33. | Zeaod | 14 | The Binding of Isaac Livestream with the Boyz #1 | 2:48:09 |
| 34. | BLOGDOT.TV | 9 | The Binding of Isaac Rebirth Gameplay Video | 5:08 |
| 35. | WWEdeadman VOD Channel | 7 | The Binding of Isaac Repentance - Stream VOD #4 | 1:59:25 |
| 36. | Weird Eurasian Boy | 7 | Live Commentary 6 [The Binding of Isaac: Rebirth gameplay] | 24:54 |
| 37. | Tentacle Gaming | 7 | The Binding of Isaac: Rebirth | Angezockt [Deutsch/PS4] | 27:01 |
| 38. | SafeWillow | 6 | The Binding of Isaac Afterbirth + | #3 Glück mit Cain/Blue Baby | 1:05:56 |
| 39. | ThreeTwoPlay | 5 | Special - The Binding of Isaac: Repentance #001 | 2:36:28 |
| 40. | Alex 灰色 | 4 | ADVENTSKALENJDER TÜRCHEN 14 The Binding of Isaac Rebirth | 46:26 |
| 41. | Panteqz Plays | 4 | THE BINDING OF ISAAC REBIRTH ✘ ANGEZOCKT #11 | Panteqz | 0:00 |
| 42. | Alextv98 | 1 | Do it! - Friendgesteuert | mit Rappi und The Binding of Isaac: Afterbirth + | #2 | 1:16:30 |
| 43. | Dova | 0 | 1) Heul dich durch, Isaac | 11:05 |
