| 1. |  Rhapsody | 123,914 | Let's Play The Binding of Isaac Afterbirth+: Tried - Episode 53 | 53:50 |
| 2. | VoltMates | 1,335 | Getting Tainted Apollyon - Binding Of Isaac Co-op - EP 13 | 30:00 |
| 3. | JaWoodle | 570 | FIRE CHAINSAW! BERSERK MODE! | MiniDoom 2 Gameplay | Indie Game Playthrough| Episode 6 | 14:33 |
| 4. | THEREALSPARTAN | 381 | Let's play the binding of Isaac: Afterbirth Episode 4: The lost VS Hush! (100th video special) | 17:43 |
| 5. | Ricky Summer | 237 | The Binding of Isaac: Rebirth • Pilot Episode • The Roleplay Gamer Plays | 21:28 |
| 6. | Lachy Plays Games | 101 | Let's Play The Binding Of Isaac Rebirth, The Greatest Remake | 15:35 |
| 7. | Scoots | 42 | Scoots Plays Games #3 (Live Stream) | 1:06:27 |
| 8. | El Gringo | 28 | KNIFESTONE, BIG BRAIN PLAYS - The Binding of Isaac: Repentance | EP0023 | 44:06 |
| 9. | AZHES | 16 | I have a Breakdown playing this game - Azhes Plays I want to be human | 16:55 |
| 10. | Ashkatom | 16 | The Binding of Isaac: Afterbirth | Let's Play [05] | HARD Mode | Samson | 47:18 |
| 11. | Delzafertin | 11 | I FINISHED THE GAME FIRST TRY: the binding of isaac rebirth lets play | 32:23 |
| 12. | TheDoctorQue | 10 | TheDoctorQue Plays The Binding of Isaac: Rebirth - Part 1 | 9:54 |
| 13. | DocFirebird After Dark - Raw Explicit Uncut | 8 | Doc plays Binding of Isaac while talking about CBT + Flattening | 3:39:14 |
| 14. | SUSS | 4 | Let's Play The Binding Of Isaac Rebirth - Best Run Ever? - #1 | 14:43 |
| 15. | Slice of Kris | 2 | Slice of Kris Plays - The Binding of Issac 17 [Doctor Fetus 2....?] | 40:22 |
| 16. | Arozay | 1 | Repentance: Isaac (Hard) Final Ending Playthrough | 1:12:46 |
| 17. | Seankichu LIVE Stream Archives | 0 | 2022-06-05 | A Way To Die - Be The Virus, Kill Your Human | Seankichu Suddenly Plays | 5:39:59 |
| 18. | GamerLeftunder | 0 | binding of isaac repentance # 2 Welp hear we go again XD i guess i just die XD | 23:51 |
