| 1. |  CybeR | INNOCENCE GLITCHED [The Binding of Isaac animation] | 1,981,195 | |
| 2. | Heartybbq | Top 5 Breaking Combos in The Binding of Isaac: Afterbirth | 269,280 | |
| 3. | MrMacRight | Top 15 New App Store Games (September - October 2023) | 200,066 | |
| 4. | Heartybbq | Top 5 Glitches in the Binding of Isaac Afterbirth | 172,868 | |
| 5. | TheSalbolt | The FINAL Ending | Afterbirth+ | Binding of Isaac | 103,248 | |
| 6. | iNtenseAussie | The Binding of Isaac Rebirth: Breaking The Game! | 94,772 | |
| 7. | DarkViperAU Livestreams | Is This Game as Hard as They Say it is? - The Binding of Isaac: Repentance - Part 1 (VOD) | 78,787 | |
| 8. | Heartybbq | Top 5 Viewer Combos: The Binding of Isaac: Afterbirth | 55,221 | |
| 9. | TheSalbolt | NEW BOSS - Golden Ultra Greed | Afterbirth + Greedier Mode | 46,455 | |
| 10. | Danger Dolan | 10 Creepy Video Game Bosses in Non-Creepy Games | 42,606 | |
| 11. | Dumb Ways to Die | Dumb Ways to Survive: Survival 101! | 40,186 | |
| 12. | iNtenseAussie | The Binding of Isaac: Rebirth - How to drop trinkets, Pills or Cards | 38,199 | |
| 13. | Ademiere | Tower of Big Hole (ToBH) - JToH Ring 2 | 37,435 | |
| 14. | Ademiere | Tower of Never Ending Dizziness (ToNED) - JToH Ring 7 | 37,232 | Guide |
| 15. | Ademiere | Tower of Yearning Victory (ToYV) - JToH Ring 7 | 30,142 | |
| 16. | DarkViperAU Livestreams | Is Beating The Game Even Possible? - The Binding Of Isaac: Repentance - Part 2 (VOD) | 28,573 | |
| 17. | DarkViperAU Livestreams | This is Getting EXTREMELY Difficult - The Binding Of Isaac: Repentance - Part 7 (VOD) | 27,080 | |
| 18. | Ademiere | Tower of Ultraviolet (ToU) - JToH Ring 7 | 26,457 | |
| 19. | DarkViperAU Livestreams | I Finally Beat Mom! - The Binding Of Isaac: Repentance - Part 4 (VOD) | 24,707 | |
| 20. | DarkViperAU Livestreams | Hard Mode Is Worse Than I Expected - The Binding Of Isaac: Repentance - Part 6 (VOD) | 23,530 | |
| 21. | SergeantWombat | Brimstone + Almond Milk Synergy | The Binding of Isaac Repentance | 23,198 | |
| 22. | funkygorilla93 | Stargazer (Planetarium) - The Binding of Isaac: Repentance (Piano) | 22,805 | |
| 23. | Ademiere | Tower of Terrain Climbing Adventures (ToTCA) - JToH April Fools 2022 | 22,742 | Guide |
| 24. | DarkViperAU Livestreams | Do I Have To Do Everything Again Now? - The Binding Of Isaac: Repentance - Part 17 (VOD) | 21,551 | |
| 25. | DarkViperAU Livestreams | This Game Is Getting So Frustrating - The Binding Of Isaac: Repentance - Part 3 (VOD) | 20,710 | |
| 26. | HappyDays | The Binding of Isaac AFTERBIRTH: LONGLEGS | GHOST BABY | DARK | EP 1 | Bonus Happy | 19,542 | |
| 27. | iNtenseAussie | The Binding of Isaac Rebirth: How to Find Secret Rooms! | 19,282 | Guide |
| 28. | funkygorilla93 | Home - The Binding of Isaac: Repentance (Piano) | 19,201 | |
| 29. | DarkViperAU Livestreams | I Finally Beat HARD MODE! - The Binding Of Isaac: Repentance - Part 14 (VOD) | 19,185 | |
| 30. | DarkViperAU Livestreams | This Game Is IMPOSSIBLE To Beat - The Binding Of Isaac: Repentance - Part 8 (VOD) | 19,184 | |
| 31. | DarkViperAU Livestreams | I Am Getting So Close Every Time! - The Binding Of Isaac: Repentance - Part 9 (VOD) | 19,065 | |
| 32. | DarkViperAU Livestreams | Encountering SATAN for the First Time! - The Binding Of Isaac: Repentance - Part 16 (VOD) | 18,968 | |
| 33. | DarkViperAU Livestreams | This Was One Of The Hardest Runs I've Done Lately - The Binding Of Isaac: Repentance - Part 19 (VOD) | 18,930 | |
| 34. | DarkViperAU Livestreams | What Is This Place? Where Am I? - The Binding Of Isaac: Repentance - Part 18 (VOD) | 18,631 | |
| 35. | DarkViperAU Livestreams | I Am My Worst Enemy In This Game - The Binding Of Isaac: Repentance - Part 10 (VOD) | 18,493 | |
| 36. | DarkViperAU Livestreams | Doing My First Challenge - The Binding Of Isaac: Repentance - Part 5 (VOD) | 18,312 | |
| 37. | DarkViperAU Livestreams | This Character is AWESOME! - The Binding Of Isaac: Repentance - Part 23 (VOD) | 17,790 | |
| 38. | DarkViperAU Livestreams | Why Am I Still Dying To This Game? - The Binding Of Isaac: Repentance - Part 13 (VOD) | 16,628 | |
| 39. | DarkViperAU Livestreams | I Hate My Mother! - The Binding Of Isaac: Repentance - Part 12 (VOD) | 16,506 | |
| 40. | DarkViperAU Livestreams | I Destroyed Greed Mode In My First Attempt! - The Binding Of Isaac: Repentance - Part 15 (VOD) | 16,419 | |
| 41. | Ademiere | Steeple of Huge Pain (SoHP) - JToH Forgotten Ridge | 16,344 | |
| 42. | DarkViperAU Livestreams | I Have Actually Gotten Better At The Game - The Binding Of Isaac: Repentance - Part 22 (VOD) | 16,297 | |
| 43. | OreOscar | The Noobs - The 10 Types of Binding of Isaac Players | 15,611 | |
| 44. | DarkViperAU Livestreams | This is the Worst Possible Way to Fail! - The Binding Of Isaac: Repentance - Part 11 (VOD) | 15,593 | |
| 45. | DarkViperAU Livestreams | How Did This Become One Of My STRONGEST Runs!? - The Binding Of Isaac: Repentance - Part 32 (VOD) | 15,444 | |
| 46. | DarkViperAU Livestreams | This Became One Of My Best Runs! - The Binding Of Isaac: Repentance - Part 25 (VOD) | 15,389 | |
| 47. | funkygorilla93 | Genesis II / Retake Light - The Binding of Isaac Repentance (Piano) | 14,732 | |
| 48. | funkygorilla93 | River of Despair (Downpour) - The Binding of Isaac: Repentance (Piano) | 14,705 | |
| 49. | iNtenseAussie | The Binding of Isaac: Rebirth - How To Find Tinted Rocks | 14,574 | Guide |
| 50. | Ademiere | Tower of Onerous Traversing (ToOT) - JToH Ring 7 | 14,344 | Guide |
| 51. | HappyDays | Happy Days 7 Days of Games | Day 2 - Binding of Isaac Afterbirth | Bonus Happy | 14,153 | |
| 52. | DarkViperAU Livestreams | I am DELETING This Character! - The Binding Of Isaac: Repentance - Part 21 (VOD) | 13,547 | |
| 53. | DarkViperAU Livestreams | Haven't I Killed Satan Enough Times Already? - The Binding Of Isaac: Repentance - Part 36 (VOD) | 13,467 | |
| 54. | DarkViperAU Livestreams | The Game Is Slowly Revealing Itself - The Binding Of Isaac: Repentance - Part 31 (VOD) | 13,438 | |
| 55. | DarkViperAU Livestreams | I Understand How This Works Now! - The Binding Of Isaac: Repentance - Part 27 (VOD) | 13,331 | |
| 56. | DarkViperAU Livestreams | I May Have Failed Last Time But Not Today! - The Binding Of Isaac: Repentance - Part 34 (VOD) | 12,974 | |
| 57. | DarkViperAU Livestreams | I Have NEVER Seen This Before - The Binding Of Isaac: Repentance - Part 48 (VOD) | 12,782 | |
| 58. | HappyDays | The Binding of Isaac AFTERBIRTH | QUAD SHOT | HOLY MANTLE | SATAN BOSS | EP 4 | 12,661 | |
| 59. | DarkViperAU Livestreams | This Character Is Absolutely TERRIBLE! I Hate Him - The Binding Of Isaac: Repentance - Part 20 (VOD) | 12,640 | |
| 60. | OreOscar | The Rebirths - The 10 Types of Binding of Isaac Players | 12,437 | |
| 61. | DarkViperAU Livestreams | I Unlocked A New Character! - The Binding Of Isaac: Repentance - Part 33 (VOD) | 12,287 | |
| 62. | DarkViperAU Livestreams | This Turned Out To Be Harder Than I Expected - The Binding Of Isaac: Repentance - Part 24 (VOD) | 12,285 | |
| 63. | DarkViperAU Livestreams | I'm Done... This Game Finally Broke Me! - The Binding Of Isaac: Repentance - Part 29 (VOD) | 12,158 | |
| 64. | HappyDays | The Binding of Isaac AFTERBIRTH: BRIMSTONE | GOAT'S HEAD | PENTAGRAM | EP 2 | Bonus Happy | 11,843 | |
| 65. | DarkViperAU Livestreams | ULTRA HARD IS ABSOLUTELY TERRIBLE! - The Binding Of Isaac: Repentance - Part 85 (VOD) | 11,758 | |
| 66. | DarkViperAU Livestreams | Will The Game Let Me Progress This Time? - The Binding Of Isaac: Repentance - Part 30 (VOD) | 11,703 | |
| 67. | DarkViperAU Livestreams | How Do I Play This Character? - The Binding Of Isaac: Repentance - Part 26 (VOD) | 11,174 | |
| 68. | DarkViperAU Livestreams | This Character Rewards Me For Being Bad! - The Binding Of Isaac: Repentance - Part 35 (VOD) | 10,989 | |
| 69. | DarkViperAU Livestreams | Can I Unlock All Of The Characters? - The Binding Of Isaac: Repentance - Part 28 (VOD) | 10,988 | |
| 70. | DarkViperAU Livestreams | That Had A MILLIONS TO ONE Chance of Happening! - The Binding Of Isaac: Repentance - Part 49 (VOD) | 10,962 | |
| 71. | DarkViperAU Livestreams | WHAT IS THIS MONSTER? - The Binding Of Isaac: Repentance - Part 52 (VOD) | 10,934 | |
| 72. | TheSalbolt | NEW FINAL BOSS - Delirium | Afterbirth + | Binding of Isaac | 10,879 | |
| 73. | HappyDays | The Binding of Isaac AFTERBIRTH: EDEN | CRICKET & GUPPY | BELIAL | EP 3 | Bonus Happy | 10,843 | |
| 74. | DarkViperAU Livestreams | I Made The Wrong Decisions... - The Binding Of Isaac: Repentance - Part 47 (VOD) | 10,797 | |
| 75. | TheSalbolt | ENDING 19 | Afterbirth + | Binding of Isaac | 10,699 | |
| 76. | DarkViperAU Livestreams | This Is Disgusting... - Highbrow Challenge - The Binding Of Isaac: Repentance - Part 37 (VOD) | 10,658 | |
| 77. | DarkViperAU Livestreams | Why Are My Tears SO SMALL!? - The Binding Of Isaac: Repentance - Part 38 (VOD) | 10,284 | |
| 78. | OreOscar | The Casuals - The 10 Types of Binding of Isaac Players | 9,955 | |
| 79. | DarkViperAU Livestreams | I Became So FAT and SLOW... - The Binding Of Isaac: Repentance - Part 39 (VOD) | 9,952 | |
| 80. | DarkViperAU Livestreams | The ULTRA HARD Challenge is ABSOLUTE TORTURE! - The Binding Of Isaac: Repentance - Part 84 (VOD) | 9,844 | |
| 81. | DarkViperAU Livestreams | The Suicide King! - The Binding Of Isaac: Repentance - Part 43 (VOD) | 9,537 | |
| 82. | OreOscar | The Pros - The 10 Types of Binding of Isaac Players | 9,499 | |
| 83. | PipeTron | 🔴 LET'S BEAT BINDING OF ISAAC | 9,424 | |
| 84. | DarkViperAU Livestreams | Can I Unlock The Polaroid This Run? - The Binding Of Isaac: Repentance - Part 51 (VOD) | 9,324 | |
| 85. | DarkViperAU Livestreams | How Hard Can It Be? - The Binding Of Isaac: Repentance - Part 41 (VOD) | 8,837 | |
| 86. | DarkViperAU Livestreams | Why Is This Challenge So Hard? - The Binding Of Isaac: Repentance - Part 40 (VOD) | 8,835 | |
| 87. | DarkViperAU Livestreams | ALL DOORS ARE CURSED!? - The Binding Of Isaac: Repentance - Part 46 (VOD) | 8,803 | |
| 88. | DarkViperAU Livestreams | How Am I Still Making Dumb Decisions? - The Binding Of Isaac: Repentance - Part 50 (VOD) | 8,734 | |
| 89. | DarkViperAU Livestreams | First Time Playing The ULTRA HARD CHALLENGE in The Binding Of Isaac: Repentance - Part 82 (VOD) | 8,458 | |
| 90. | DarkViperAU Livestreams | When Life Gives You Lemons... - The Binding Of Isaac: Repentance - Part 53 (VOD) | 8,437 | |
| 91. | DarkViperAU Livestreams | The Game Made Me Fart Everywhere - The Binding Of Isaac: Repentance - Part 54 (VOD) | 8,426 | |
| 92. | Blarue | The Binding of Isaac: Pong | 8,301 | |
| 93. | DarkViperAU Livestreams | I Fought The TRUE FINAL BOSS For the FIRST Time! - The Binding Of Isaac: Repentance - Part 101 (VOD) | 8,298 | |
| 94. | DarkViperAU Livestreams | A New Path is Revealed - The Binding Of Isaac: Repentance - Part 96 (VOD) | 8,180 | |
| 95. | DarkViperAU Livestreams | This Is The WORST Challenge To Ever Exist! - The Binding Of Isaac: Repentance - Part 72 (VOD) | 8,148 | |
| 96. | Heartybbq | Why You Should Always Use the D100 Featuring Eve | 8,078 | |
| 97. | DarkViperAU Livestreams | This Run Turned Out To Be Easier Than Expected - The Binding Of Isaac: Repentance - Part 45 (VOD) | 7,765 | |
| 98. | DarkViperAU Livestreams | I Am Finally Returning To HARD MODE! - The Binding Of Isaac: Repentance - Part 91 (VOD) | 7,493 | |
| 99. | DarkViperAU Livestreams | I Became The Minion Master! - The Binding Of Isaac: Repentance - Part 60 (VOD) | 7,418 | |
| 100. | DarkViperAU Livestreams | The Most Destructive Run I've Done In This Game! - The Binding Of Isaac: Repentance - Part 62 (VOD) | 7,330 | |
