1. | DangerouslyFunny | This Game Is Free | 1,507 | |
2. | DangerouslyFunny | When You Do So Much Damage Bosses Die Almost Instantly in The Binding Of Isaac: Rebirth | 1,113 | |
3. | DangerouslyFunny | When You Finally Find The Perfect Powerups in The Binding Of Isaac Rebirth | 1,052 | |
4. | DangerouslyFunny | This Somehow Carried Me Through The Boss in The Binding Of Isaac Rebirth | 1,047 | |
5. | Kate Lovelymomo | The Binding of Isaac: Rebirth Co-Op with Northernlion [Episode 1] Seed to defeat Satan | 1,002 | |
6. | DangerouslyFunny | I Built The Worst Super Laser Ever in The Binding Of Isaac Rebirth | 933 | |
7. | 2 Left Thumbs | Riddle School / Riddle Transfer: Flash Game History (Riddle School Legacy) | Flashlight | 810 | |
8. | DangerouslyFunny | Creating A Crazy Superlaser in The Binding Of Isaac Rebirth | 701 | |
9. | Lumpy Touch | Pokémon + Binding of Isaac FUSIONS | 663 | |
10. | DangerouslyFunny | I Forced Everything To Suffer With Spiders | 642 | |
11. | Gorange | Bonk Lord Requiem | Binding of Isaac: Repentance | 530 | |
12. | DangerouslyFunny | When I Have More Money Than I Can Actually Use in The Binding Of Isaac: Rebirth | 517 | |
13. | Gorange | Jacob and Esau Unavoidable Damage | Binding of Isaac: Repentance | 510 | |
14. | Kate Lovelymomo | The Binding of Isaac Antibirth with Northernlion [Episode 1] | 479 | |
15. | DangerouslyFunny | Fighting A Room Full Of Bosses With Super Tears in The Binding Of Isaac Rebirth | 477 | |
16. | xQc | xQc Plays The Binding of Isaac: Afterbirth+ | xQcOW | 461 | Let's Play |
17. | DangerouslyFunny | Upgrading An Idiot Into A God | 412 | |
18. | Gorange | Tainted Blue Baby Guide | Binding of Isaac: Repentance | 404 | Guide |
19. | Kate Lovelymomo | The Binding of Isaac: Rebirth Co-op with Northernlion [Episode 2] Tsunami Tear | 354 | |
20. | Gorange | Panic Button + Learn to Jump, OVERPOWERED SYNERGY | Binding of Isaac: Repentance | 349 | |
21. | Gorange | Seeing Double | Binding of Isaac: Repentance | 331 | |
22. | Gorange | Tainted Judas DESTROYS Hush with NO ITEMS | Binding of Isaac: Repentance | 323 | |
23. | PauseUnpause | Livestream Voice Troll | 322 | |
24. | Gorange | DELETE THIS | Binding of Isaac: Repentance | 319 | |
25. | lucahjin | One Night Stand - Binding of Isaac Rebirth! | 304 | |
26. | Gorange | Why you should ALWAYS install random mods | 292 | |
27. | Gorange | THE BONKLORD | Binding of Isaac: Repentance | 290 | |
28. | Sickmmaner | TBOI Juggernaut but Isaac is the Big Man | 290 | |
29. | Gorange | Red Redemption | Binding of Isaac: Repentance | 280 | |
30. | Gorange | Tainted Isaac Almost Crashed My Game | Binding of Isaac: Repentance | 280 | |
31. | Gorange | Tainted Cain in Greed Mode be like.. | Binding of Isaac: Repentance | 261 | |
32. | SmallAnt VODS | SmallAnt plays a game he is bad at | 259 | |
33. | DangerouslyFunny | How I Became the Strongest | 252 | |
34. | Gorange | Tainted Azazel Sneeze Only | Binding of Isaac: Repentance | 247 | |
35. | Gorange | 120 Volt + Pause = Easy Win | Binding of Isaac: Repentance | 238 | |
36. | Gorange | Hot Potato | Binding of Isaac: Repentance | 237 | |
37. | Gorange | Dark Arts Only | Binding of Isaac: Repentance | 236 | |
38. | Gorange | Finders Keepers | Binding of Isaac: Repentance | 231 | |
39. | RomeLIVE | Someone Is STEALING My Content: | 222 | |
40. | Kate Lovelymomo | The Binding of Isaac Antibirth with Northernlion [Episode 2] | 209 | |
41. | Gorange | When Forgotten mains play another character | 206 | |
42. | Gorange | Tainted Lilith Slaps Everyone | Binding of Isaac: Repentance | 200 | |
43. | Gorange | Belson | 198 | |
44. | PauseUnpause | The Blues (The Binding of Isaac: Rebirth #89) | 197 | Walkthrough |
45. | Danzel Glovington | "The Bandage" Extremely Rare Achievement Unlocked - Binding of Isaac: Rebirth | 196 | |
46. | Kate Lovelymomo | The Binding of Isaac: Rebirth Co-Op with Northernlion [Episode 3] Football Coach Ryan | 185 | |
47. | Gorange | The Exorcist Haunts My Run | 177 | |
48. | Gorange | Only Dead Lazarus Can Take Items | Binding of Isaac: Repentance | 174 | |
49. | Kate Lovelymomo | The Binding of Isaac: Afterbirth Co-op with Northernlion [Episode 1] | 171 | |
50. | Gorange | Baptism by Fire | Binding of Isaac: Repentance | 170 | |
51. | Kate Lovelymomo | The Binding of Isaac Afterbirth+ Race with Northernlion [Episode 1] | 169 | |
52. | Pikasprey Blue | The Binding of Isaac: Afterbirth+ | PART 1 | 167 | |
53. | Kate Lovelymomo | The Binding of Isaac Antibirth with Northernlion [Episode 4] | 163 | |
54. | Gorange | Tainted Glare is Cutting Edge | 159 | |
55. | Kate Lovelymomo | The Binding of Isaac: Afterbirth+ with Northernlion [Episode 1] | 156 | |
56. | Gorange | jon | 152 | |
57. | Gorange | Clutch - NEW Repentance Boss | 150 | |
58. | PauseUnpause | It's Finally Released! (The Binding of Isaac: Rebirth #1) | 142 | |
59. | PauseUnpause | Racing With Millbee (The Binding of Isaac: Rebirth #5) | 139 | Walkthrough |
60. | Gorange | Pica Run | Binding of Isaac: Repentance | 133 | |
61. | Gorange | Kids Shouldn't Believe in Fortunes | Binding of Isaac: Repentance | 133 | |
62. | Gorange | Tainted Eve VS The Beast NO ITEMS | Binding of Isaac: Repentance | 131 | |
63. | PauseUnpause | Number 6 (The Binding of Isaac: Rebirth #25) | 131 | Walkthrough |
64. | Graeme Games | Everything we know about ISAAC: REPENTANCE -- The Binding of Isaac Repentance Theories | 126 | |
65. | Kate Lovelymomo | The Binding of Isaac Antibirth with Northernlion [Episode 7] | 122 | |
66. | PauseUnpause | Jera Madness (The Binding of Isaac: Rebirth #90) | 119 | Walkthrough |
67. | PauseUnpause | Awkward Nostalgia (Triple Eh Mondays #4) | 119 | |
68. | Gorange | Tainted Eve VS Mother NO ITEMS | Binding of Isaac: Repentance | 119 | |
69. | Viantastic | Dear Woomy | Splatoon with Binding of Isaac Sounds | 118 | |
70. | Gorange | Tainted Blue Baby (NO ITEMS) Only Poop | Binding of Isaac: Repentance | 117 | |
71. | Gorange | Tainted Judas DESTROYS Mother with NO ITEMS | Binding of Isaac: Repentance | 116 | |
72. | Woofless | Binding of Isaac Rebirth: Super Mad Issac and Half Heart Warrior! | 116 | |
73. | PurpleColonel | The Binding of Isaac: REPENTROSPECTIVE (Review/Analysis) | 115 | |
74. | Gorange | doing the unthinkable | 114 | |
75. | MattShea | Starting as a BATTLE CAT! (The Binding of Isaac) | 114 | |
76. | RomeLIVE | This Character Gives The BEST Items! | 109 | |
77. | Gorange | Dopamine Remover 3000™ | 108 | |
78. | Gorange | The Best Isaac Mod Doesn't Exist | 106 | |
79. | Kate Lovelymomo | The Binding of Isaac Antibirth with Northernlion [Episode 3] | 106 | |
80. | Gorange | Arachna Is Sackingly Fun | 106 | |
81. | Gorange | Existential Keeper | Binding of Isaac: Repentance | 105 | |
82. | Gorange | This Character Is Shockingly Fun | 104 | |
83. | Gorange | Playable Ultra Greed Takes Your Lunch Money | 104 | |
84. | Gorange | TOP 10 REASONS WHY NEEDLES ARE BAD | 103 | |
85. | Gorange | Answering YOUR Questions | 103 | |
86. | PauseUnpause | OP (The Binding of Isaac: Rebirth #15) | 102 | Walkthrough |
87. | Kate Lovelymomo | The Binding of Isaac: Afterbirth Co-op with Northernlion [Episode 2] Sashimi | 101 | |
88. | Gorange | Isaac's Awakening | Binding of Isaac: Repentance | 100 | |
89. | PauseUnpause | It's Me! (The Binding of Isaac: Rebirth #30) | 98 | Walkthrough |
90. | PauseUnpause | BrimKnife (The Binding of Isaac: Rebirth #23) | 97 | Walkthrough |
91. | PauseUnpause | Scythe Strength (The Binding of Isaac: Rebirth #102) | 97 | Walkthrough |
92. | PauseUnpause | 999! (The Binding of Isaac: Rebirth #97) | 96 | Walkthrough |
93. | PauseUnpause | So Much Fun (The Binding of Isaac: Rebirth #72) | 96 | Walkthrough |
94. | PauseUnpause | Baby (The Binding of Isaac: Rebirth #100) | 96 | Walkthrough |
95. | Gorange | Edith the Drift King | 95 | |
96. | GriffyBit | I Played 5 Pixel Art Games You've Never Heard Of | 95 | |
97. | Sickmmaner | Floor Transition Screen Rebirth vs Repentance | 95 | |
98. | Gorange | Edith the Seratonin Stomper | 94 | |
99. | Gorange | Scat Man | Binding of Isaac: Repentance | 94 | |
100. | Kate Lovelymomo | The Binding of Isaac: Rebirth [Episode 2] Proud Moment! | 93 | |