| 1. |  SebasTorrón | Exploit PS Vita FW 3.35 Instantáneo (En Desarrollo), 3DS CFW - VEV #12 (Binding Of Isaac: Rebirth) | 21,949 | |
| 2. | Olmi | The clutch crane game (Binding of Isaac) | 2,665 | |
| 3. | Olmi | Apollyon. The Binding Of Isaac's Most Underwhelming Character | 2,255 | |
| 4. | Yddra | Descargar The Binding Of Isaac Afterbirth Plus Booster Pack 5 Ultima Version Gratis PC | 1,618 | |
| 5. | Yddra | Descargar The Binding Of Isaac AfterBirth Plus Update 16 Ultima Version | 1,513 | Vlog |
| 6. | Lead3r | The Biggest Youtube Glitch in history | 249 | |
| 7. | Eeemessi | Cheating 2 leak | 217 | |
| 8. | Lead3r | Top 3 Roguelikes (That i have played) part 1 | 159 | |
| 9. | Franci Games | Jugando The Binding Of Isaac Repentance En Directo. | 149 | |
| 10. | Yddra | Descargar The Binding Of Isaac AfterBirth Plus Update 16 Ultima Version | 129 | Vlog |
| 11. | MarcosDSA | TBoI | Empieza el reto de las 100 wins seguidas | 68 | |
| 12. | Neru RG | Binding of Isaac repentance | 60 | |
| 13. | e0liu | Worst noise 2022 | 56 | |
| 14. | Neru RG | Binding of Isaac repentance | 48 | |
| 15. | MarcosDSA | TBoI | Run remontada | Reto de las 100 victorias consecutivas (parte 5) | 45 | |
| 16. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 1 | 39 | |
| 17. | MarcosDSA | TBoI | De los peores inicios que he tenido :c | Reto de las 100 victorias consecutivas (parte 2) | 36 | |
| 18. | MarcosDSA | TBoI | Primer intento con The Lost | Reto de las 100 victorias consecutivas (parte 4) | 35 | |
| 19. | Arielcito | Le rompí el cul0 a mama... | 34 | |
| 20. | RECLAMO GAMING | JUEGOS INDIES PENDIENTES DE SALIDA 2021. UPCOMING INDIE GAMES 2021. | 33 | |
| 21. | MarcosDSA | TBoI | 2 runs no muy divertidas 🥱 | Reto de las 100 victorias consecutivas (parte 7) | 31 | |
| 22. | MarcosDSA | TBoI | The void con Judas | Reto de las 100 victorias consecutivas (parte 8) | 21 | |
| 23. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 3 | 19 | |
| 24. | MarcosDSA | TBoI | Situaciones tercermundistas | Reto de las 100 victorias consecutivas (parte 6) | 17 | |
| 25. | Arielcito | Hice una run de isaac pero se jodio el audio y subí el video en cámara rápida | 13 | |
| 26. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 4 | 12 | Let's Play |
| 27. | Arielcito | Final inesperado, me mata un gordo | 12 | |
| 28. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 6 | 11 | Let's Play |
| 29. | Arielcito | la mausquherramienta me arruino la vida | 10 | |
| 30. | MarcosDSA | TBoI | Rompí la run | Reto de las 100 victorias consecutivas (parte 3) | 10 | |
| 31. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 7 | 9 | Let's Play |
| 32. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 9 | 9 | Let's Play |
| 33. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 2 | 9 | |
| 34. | Jean4everTV | No se cuantas partidas de Isaac en un strim | 9 | |
| 35. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 5 | 7 | Let's Play |
| 36. | Jean4everTV | First Blood... - The Binding of Isaac Afterbirth+ Ep #1 | 7 | |
| 37. | Arielcito | Soy malisimo compa | 7 | |
| 38. | e0liu | e0liu Plays... The Binding of Isaac: Afterbirth+ | Part 8 | 5 | Let's Play |
