| 1. |  YaraskyPlays | Promo YaraskyPlays | 25,021 | Let's Play |
| 2. | Serpent | BESTE ONTMAAGDING OOIT - The Binding Of Isaac: Rebirth Playthrough Deel 1 | 19,029 | Let's Play |
| 3. | SiIvaGunner | Diptera Sonata (Alpha Mix) - The Binding of Isaac: Rebirth | 16,020 | Let's Play |
| 4. | BroskiPlays! | THE BINDING OF ISAAC HD TEXTURE MOD?! - Isaac Modshowcase #1 (Isaac Realistic Textures Mod) | 15,790 | Let's Play |
| 5. | Serpent | RESET! - The Binding Of Isaac: Rebirth Playthrough Deel 2 | 13,450 | Let's Play |
| 6. | Serpent | BEAUTY AND THE BELG! - The Binding Of Isaac: Rebirth Playthrough Deel 3 | 12,932 | Let's Play |
| 7. | Serpent | BABY TE GAST! - The Binding Of Isaac: Rebirth Playthrough Deel 4 | 11,217 | Let's Play |
| 8. | Serpent | Langdradig Gelul over 2013 & 2014 | 10,460 | Let's Play |
| 9. | Serpent | I AM (T)ERROR! - The Binding Of Isaac: Rebirth Playthrough #8 | 9,914 | Let's Play |
| 10. | Serpent | TROTS & KOTS! - The Binding Of Isaac: Rebirth Playthrough Deel 6 | 9,770 | Let's Play |
| 11. | Serpent | Langdradig Gelul over 2014 & 2015 | 9,614 | Let's Play |
| 12. | Serpent | FATOE DJONKO DOEKOE! - The Binding Of Isaac: Rebirth Playthrough #7 | 9,503 | Let's Play |
| 13. | Serpent | HIPSTER EROTIEK - The Binding Of Isaac: Rebirth Playthrough Deel 5 | 9,318 | Let's Play |
| 14. | Serpent | Dora, NS en Marco Borsato - The Binding Of Isaac: Rebirth Playthrough #9 | 8,164 | Let's Play |
| 15. | BroskiPlays! | The Binding of Isaac: Afterbirth+ 101 - #3: Curses & More Floors | 6,566 | Let's Play |
| 16. | BroskiPlays! | The Binding of Isaac: AFTERBIRTH: SOY MILK + PYROMANIAC + IPECAC + DR FETUS #2 | 3,139 | Let's Play |
| 17. | Gar | The Binding of Isaac: Rebirth #49: BASEMIVT | 2,740 | Let's Play |
| 18. | Gar | The Binding of Isaac: Rebirth (Commentary) #1: Slow Start | 2,719 | Let's Play |
| 19. | BroskiPlays! | The Binding of Jesus: Holybirth+ Alpha 1.02 Update Video | 2,667 | Let's Play |
| 20. | BroskiPlays! | The Story Behind the Isaac Collectible EP 2: Ipecac (Legacy of Isaac Items) | 1,973 | Let's Play |
| 21. | BroskiPlays! | Shops (Tips, Tricks & Strategies) - The Binding of Isaac: Repentance 101 Ep. 4 | 1,961 | Let's Play |
| 22. | BroskiPlays! | OMG THIS IS HERETIC! - Isaac Modshowcase #3 - Heretic Mod | 1,652 | Let's Play |
| 23. | BroskiPlays! | The Story Behind the Isaac Collectible EP 1: Tammy's Head (Legacy of Isaac Items) | 1,623 | Let's Play |
| 24. | Gar | The Binding of Isaac: Rebirth (Commentary) #86: The Dream | 1,537 | Let's Play |
| 25. | BroskiPlays! | THE BIGGEST MODDED RUN EVER! - 12+ MODPACKS OVER 1000 ITEMS & MORE! | 1,495 | Let's Play |
| 26. | BroskiPlays! | KING SAUL & THE DRAWN! - AB+ DAILY MODDED RUN #4 | 1,346 | Let's Play |
| 27. | Gar | The Binding of Isaac: Afterbirth (Commentary) #1: First Run | 1,329 | Let's Play |
| 28. | Gar | The Binding of Isaac: Afterbirth (Commentary) #6: Waka Waka | 1,233 | Let's Play |
| 29. | Gar | The Binding of Isaac: Rebirth (Commentary) #3: Edenigma | 1,081 | Let's Play |
| 30. | Gar | The Binding of Isaac: Rebirth (Commentary) #2: Pazazzel | 1,075 | Let's Play |
| 31. | BroskiPlays! | ALPHABIRTH?! - Isaac ModShowcase #7 - AlphaBirth: A Mom's Closet & All That is Unholy | 1,017 | Let's Play |
| 32. | BroskiPlays! | WIN THE BINDING OF ISAAC REBIRTH FOR IOS?! - 1K SUBS GIVEAWAY (Antibirth Run Special!) | 978 | Let's Play |
| 33. | Gar | The Binding of Isaac: Rebirth (Commentary) #22: God Mode | 937 | Let's Play |
| 34. | Gar | The Binding of Isaac: Rebirth (Commentary) #32: Hope | 934 | Let's Play |
| 35. | Gar | The Binding of Isaac: Rebirth (Commentary) #4: Samnoms | 895 | Let's Play |
| 36. | arjandotorg | [The Binding of Isaac: Rebirth] Een eerste indruk | 893 | Let's Play |
| 37. | Gar | The Binding of Isaac: Rebirth (Commentary) #20: Isaac Isaac | 770 | Let's Play |
| 38. | Gar | The Binding of Isaac: Rebirth (Commentary) #14: Hilambarus | 769 | Let's Play |
| 39. | Gar | The Binding of Isaac: Rebirth (Commentary) #6: Solar System | 761 | Let's Play |
| 40. | Gar | The Binding of Isaac: Rebirth (Commentary) #7: Balanced | 757 | Let's Play |
| 41. | Gar | The Binding of Isaac: Rebirth (Commentary) #10: Brains | 745 | Let's Play |
| 42. | Gar | The Binding of Isaac: Rebirth (Commentary) #12: Evening | 745 | Let's Play |
| 43. | Gar | The Binding of Isaac: Rebirth (Commentary) #17: ? | 744 | Let's Play |
| 44. | Gar | The Binding of Isaac: Rebirth (Commentary) #5: Computer Savvy | 731 | Let's Play |
| 45. | Gar | The Binding of Isaac: Rebirth (Commentary) #18: Sad Bob | 723 | Let's Play |
| 46. | Gar | The Binding of Isaac: Afterbirth (Commentary) #5: Greelith | 712 | Let's Play |
| 47. | Gar | The Binding of Isaac: Afterbirth (Commentary) #4: Ayyyy Whaz | 689 | Let's Play |
| 48. | Gar | The Binding of Isaac: Rebirth (Commentary) #13: Caintrain | 688 | Let's Play |
| 49. | Gar | The Binding of Isaac: Rebirth (Commentary) #16: Shielded Death | 686 | Let's Play |
| 50. | Gar | The Binding of Isaac: Rebirth (Commentary) #28: Spinning Head | 682 | Let's Play |
| 51. | Gar | The Binding of Isaac: Rebirth (Commentary) #26: Loops | 658 | Let's Play |
| 52. | Gar | The Binding of Isaac: Rebirth (Commentary) #9: Magdalone | 653 | Let's Play |
| 53. | Gar | The Binding of Isaac: Rebirth (Commentary) #8: Waka Waka | 637 | Let's Play |
| 54. | Gar | The Binding of Isaac: Rebirth (Commentary) #30: Gnawledge | 622 | Let's Play |
| 55. | Gar | The Binding of Isaac: Rebirth (Commentary) #15: The Host | 618 | Let's Play |
| 56. | Gar | The Binding of Isaac: Rebirth (Commentary) #76: Anghellic | 609 | Let's Play |
| 57. | Gar | The Binding of Isaac: Rebirth (Commentary) #33: The Family Man | 609 | Let's Play |
| 58. | Gar | The Binding of Isaac: Rebirth (Commentary) #23: Boring Brimbab | 600 | Let's Play |
| 59. | Gar | The Binding of Isaac: Rebirth (Commentary) #11: Cursed! | 600 | Let's Play |
| 60. | Gar | The Binding of Isaac: Afterbirth (Commentary) #2: Greedzazel | 599 | Let's Play |
| 61. | Gar | The Binding of Isaac: Rebirth (Commentary) #19: Suicide King | 594 | Let's Play |
| 62. | Gar | The Binding of Isaac: Rebirth (Commentary) #38: Unhealthy | 594 | Let's Play |
| 63. | Gar | The Binding of Isaac: Rebirth (Commentary) #25: Bobroll | 593 | Let's Play |
| 64. | Gar | The Binding of Isaac: Rebirth (Commentary) #36: Bandage Judas | 578 | Let's Play |
| 65. | Gar | The Binding of Isaac: Rebirth (Commentary) #40: Blankson | 577 | Let's Play |
| 66. | Gar | The Binding of Isaac: Rebirth (Commentary) #58: I Am Bound | 574 | Let's Play |
| 67. | Gar | The Binding of Isaac: Rebirth (Commentary) #77: Dead Sea Scrolls | 563 | Let's Play |
| 68. | Gar | The Binding of Isaac: Rebirth (Commentary) #56: λ | 560 | Let's Play |
| 69. | Gar | The Binding of Isaac: Afterbirth (Commentary) #3: Head Trauma | 559 | Let's Play |
| 70. | Gar | The Binding of Isaac: Rebirth (Commentary) #62: New Beginnings | 544 | Let's Play |
| 71. | Gar | The Binding of Isaac: Rebirth (Commentary) #57: I Am Lost | 544 | Let's Play |
| 72. | Gar | The Binding of Isaac: Rebirth (Commentary) #35: The Tank | 537 | Let's Play |
| 73. | Gar | The Binding of Isaac: Rebirth (Commentary) #75: Vortex | 533 | Let's Play |
| 74. | Gar | The Binding of Isaac: Rebirth (Commentary) #24: Brimknife | 531 | Let's Play |
| 75. | Gar | The Binding of Isaac: Rebirth (Commentary) #34: Alakazammy | 524 | Let's Play |
| 76. | Gar | The Binding of Isaac: Rebirth (Commentary) #71: Pickaxe | 521 | Let's Play |
| 77. | Gar | The Binding of Isaac: Rebirth (Commentary) #59: Intermission | 521 | Let's Play |
| 78. | Gar | The Binding of Isaac: Rebirth (Commentary) #31: When Life Gives You Lemons | 512 | Let's Play |
| 79. | Gar | The Binding of Isaac: Rebirth (Commentary) #21: Slow Roll | 509 | Let's Play |
| 80. | Gar | The Binding of Isaac: Rebirth (Commentary) #27: High Brow | 508 | Let's Play |
| 81. | Gar | The Binding of Isaac: Rebirth (Commentary) #64: Basement Promise | 505 | Let's Play |
| 82. | Gar | The Binding of Isaac: Rebirth (Commentary) #61: I Am Found | 503 | Let's Play |
| 83. | Gar | The Binding of Isaac: Rebirth (Commentary) #53: Goldfinger | 502 | Let's Play |
| 84. | Gar | The Binding of Isaac: Rebirth (Commentary) #87: Oh god | 499 | Let's Play |
| 85. | BroskiPlays! | LETS PLAY SOME FUCKING ISAAC XD LIVE | 499 | Let's Play |
| 86. | Gar | The Binding of Isaac: Rebirth (Commentary) #55: Blue Blue Baby | 494 | Let's Play |
| 87. | Milana | I need help... HOW DO I PLAY THIS GAME!? | 490 | Let's Play |
| 88. | Gar | The Binding of Isaac: Rebirth (Commentary) #29: It's In The Cards | 486 | Let's Play |
| 89. | Gar | The Binding of Isaac: Rebirth (Commentary) #42: Lazarus Time | 481 | Let's Play |
| 90. | Gar | The Binding of Isaac: Rebirth (Commentary) #46: Uncainny | 475 | Let's Play |
| 91. | Gar | The Binding of Isaac: Rebirth (Commentary) #78: JACKPOT | 474 | Let's Play |
| 92. | Gar | The Binding of Isaac: Rebirth (Commentary) #45: Purist | 474 | Let's Play |
| 93. | Gar | The Binding of Isaac: Rebirth (Commentary) #81: Jump! Jump! | 473 | Let's Play |
| 94. | Gar | The Binding of Isaac: Rebirth (Commentary) #91: Rebel | 465 | Let's Play |
| 95. | BroskiPlays! | Broski Plays: The Binding of Isaac: Afterbirth | 465 | Let's Play |
| 96. | BroskiPlays! | LUA MODDING WITH BROSKIPLAYS LIVE! | 460 | Let's Play |
| 97. | Gar | The Binding of Isaac: Rebirth (Commentary) #48: Epic Magdalene | 458 | Let's Play |
| 98. | Gar | The Binding of Isaac: Rebirth (Commentary) #60: I Am Idiot | 458 | Let's Play |
| 99. | Gar | The Binding of Isaac: Rebirth (Commentary) #44: Dead Eve | 457 | Let's Play |
| 100. | Gar | The Binding of Isaac: Rebirth (Commentary) #65: Contradiction | 456 | Let's Play |
