| 1. |  RTGame | 5,692,487 | Building A Hospital that Tries To Kill Its Patients in Two Point Hospital | 10:08 |
| 2. | Call Me Kevin | 4,715,252 | I made a hospital that kills people instead of saving them | 18:04 |
| 3. | jacksepticeye | 2,767,655 | BUILDING THE FUNNIEST HOSPITAL | Two Point Hospital | 39:34 |
| 4. | Anna Rudolf | 82,697 | Doctor Call Me Kevin | 0:00 |
| 5. | RTGame Stream Archive | 46,595 | RTGame Archive: Two Point Hospital | 2:11:17 |
| 6. | TheChrisD | 26,605 | 3 Star Pointy Pass (Speedy Recovery #3) | Two Point Hospital | 5:03:01 |
| 7. | Gameplay Only | 1,379 | Two Point Hospital Gameplay Walkthrough with Dev Commentary | 8:10 |
| 8. | MagickCore | 953 | Two Point Hospital - Trophy Cleanup - PS5 Pro, Platinum Part 26 (2024) | 0:00 |
| 9. | Yojimbo586 | 351 | Two Point Hospital Intro | 0:51 |
| 10. | Tommy Vercetti's Gaming News Gameplay Music | 159 | Two Point Hospital Sandbox Mode Update | 0:48 |
| 11. | ArcaneGamer | 48 | Two Point Hospital Part 10 - Gameplay Walkthrough | 40:04 |
| 12. | InsideAgameR | 28 | TWO POINT HOSPITAL:lets build foundations and save lives: lets play episode:1 | 23:13 |
| 13. | Low Energy Videos | 26 | Live Energy Rambles: Two Point Hospital | 52:05 |
| 14. | Mew the Switch Plays | 18 | Two Point Hospital Part 1 | 26:32 |
| 15. | Dying Legacy | 17 | Two Point Hospital - A Safari experience | 14:23 |
| 16. | CJSeedge | 13 | Two Point Hospital Review: Seedge Says RENT | 7:54 |
| 17. | A Casual Carebear Gamer | 11 | Two Point Hospital - Pelican Wharf Level 3 - Waiting for that researcher.... | 28:49 |
| 18. | SpitfireSpud Gaming | 11 | Expanding a Hospital Empire! | Two Point Hospital Gameplay | 38:27 |
| 19. | Nalum | 7 | Two Point Hospital // One Shot | 43:01 |
| 20. | SpringBaker4652 | 6 | Two Point Hospital Part 1 | 1:03:01 |
| 21. | John Brady | 2 | Two Point Hospital | 2:00:00 |
