Cells move through complex 3D environments in vivo, but studying 3D modes of migration in vitro remains a major challenge. Guetta-Terrier et al. examine the movement of cells along suspended nanofibers that mimic 3D fibrillar matrices and find that their migration is guided by fin-like protrusions that propagate away from the cell body to extend the leading edge. This biosights episode presents the paper by Guetta-Terrier et al. from the November 9th, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's corresponding authors, Benoit Ladoux (National University of Singapore and Institut Jacques Monod, Paris, France) and Nils Gauthier (National University of Singapore). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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