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Successful Cartoons that Nickelodeon Rejected:

Nickelodeon Rejected Ed, Edd n Eddy, The Grim Adventures of Billy and Mandy, Adventure Time, and The Amazing World of Gumball. All of these shows later got picked up by Cartoon Network and became huge hits for CN.

And to clarify with Ed Edd N Eddy, they initially picked up up by Dan Antonucci backed out of the deal when the network told him he wouldn’t have creative control.

Ironically years later, some of these cartoons invaded Nickelodean during a Commercial break.

As for Diseny Shows Nickelodeon rejected, this list includes: Star vs The Forces of Evil, Phineas and Ferb, The Proud Family, Gravitly Falls, The Owl House, and Pepper Ann.

Had nick picked up on these shows it would have effected the plot and quality of each series for better or for worse, considering each network has different creative freedoms for their shows.