Choose the correct statements about DNA replication. I. Discontinuo...

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Choose the correct statements about DNA replication.
I. Discontinuously synthesised fragments are later joined by the enzyme DNA ligase.
II. There is a definite region in \( E \). coli DNA where the replication originates, known as origin of replication.
III. In eukaryotes, the replication of DNA takes place at S-phase of the cell cycle.
IV. Failure of cell division after DNA replication results in polyploidy.
V. E. coli having \( 4.6 \times 10^{6} \) bp completes DNA replication within 38 minutes.
(a) I and II
(b) III and IV
(c) I and V
(d) All of these
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