Li Mei's Enhanced Nova Blast does not combo at full screen. Since the second hit connects behind the opponent, it will appear off screen and trigger an auto block instead of comboing for three hits. You will see the second and third Mid hits are blocked. Perhaps ordinarily, the first hit pushes the character into the second. At full screen without any room to be pushed backward, the character remains in place and a gap is created to allow the character to block either due to hitbox collision or frame timing. The Block All setting will stop the enhanced projectile after the first single hit without creating the second or third hit. The corner does not affect this unless you are a full screen away. It is not a glitch. It is simply an unfortunate circumstance.
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