Nanovials, a Microscopic Bowl, may Uncover Protein Secretion Mysteries
0Nanovials, a Microscopic Bowl, may Uncover Protein Secretion Mysteries
Nanovials, a Microscopic Bowl, may Uncover Protein Secretion Mysteries. Cells secret a range of proteins such as antibodies and growth factors that affect human health, but some cells secrete more than one protein. Scientists struggle to establish links between genomes, transcriptomes, and functional outputs of cells for developing cell therapies. Cell therapy is about placing new and healthy cells into the body to replace the damaged ones and to modulate the function of the patient’s cells through the expression of factors or direct interaction. It also helps to remove the disease-causing or dysfunctional cells using immune cells.
Reference:
1. Miwa H, et al. Single-cell sorting based on secreted products for functionally defined cell therapies. Microsystems Nanoeng. 2022;8(1):84.
2. Cheng RY-H, et al. SEC-seq: association of molecular signatures with antibody secretion in thousands of single human plasma cells. Nat Commun. 2023;14(1):3567.
3. Slota M, et al. ELISpot for measuring human immune responses to vaccines. Expert Rev Vaccines. 2011;10(3):299-306.
4. Vogel, C. & Marcotte, E. M. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat. Rev. Genet. 13, 227–232 (2012).
5. Peterson, V. M. et al. Multiplexed quantification of proteins and transcripts in single cells. Nat. Biotechnol. 35, 936–939 (2017).
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