"Middlesex" by Jeffrey Eugenides is a Pulitzer Prize-winning novel that follows the life of Calliope Stephanides, a Greek-American intersex individual, as they navigate issues of gender, identity, and family history. The story begins with Calliope's grandparents and their immigration to the United States, tracing their family saga through three generations. Calliope, who identifies as male but was raised as a girl due to their ambiguous physical characteristics, grapples with the complexities of their gender identity, struggling to reconcile their true self with societal expectations and cultural norms. As Calliope grows up, they embark on a journey of self-discovery, exploring their sexuality, heritage, and place in the world. Along the way, Calliope uncovers family secrets and confronts their own personal challenges, including love, loss, and self-acceptance. "Middlesex" is a thought-provoking and beautifully written novel that explores the intricacies of gender identity, cultural heritage, and the search for self, while also delving into the history and experiences of a Greek-American family in the United States.