Resident Evil 5: Boss Fight: Popokarimu
Taken from SuperCheats.com guide to Resident Evil 5: http://www.supercheats.com/guides/resident-evil-5/train-station
It appears this boss is completely invulnerable to your bullets, or is it? This video reveals all weaknesses of Popokarimu.
This creature requires a special strategy to defeat. You'll soon find that its armor is too tough to crack with regular gunfire. It's weak spot is the pink flesh at the bottom of it's tail. With the natural cflow of things, this will be revealed when it's in the air or when it has just performed a leap attack.
However, you'll want to get a longer time span for targetting this weak spot. There are sets of 3, 2, and 3 wooden barrels in the area, and one of the cabins houses 2x handgun ammo x10, a green herb and a proximity bomb. Those bombs can also be found in many of the crates, and they're the key to an easy victory.
Get a fair distance between you and the boss, ideally so that you are on one side of the rock in the center and he on the other side. Place a Proximity Bomb in the middle of the road and lure the boss towards it. While the boss is heading towards the bomb, be sure that your best weapon(s) are fully loaded. The blast will knock the boss on its side, revealing the weak spot located under its tail. Walk over to a convenient spot, usually right next to the weak spot and empty your shotgun/machine gun/favorite weapon. Repeat this process a few times and the boss will be a goner.
If the boss stays in the air for a little while, try to shoot it down so you can place another proximity bomb and lure it towards the bomb.
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