Duration: 7:30

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This is hands down one of the hardest things in this game. The first four bosses aren't too difficult, but once you get to Francis, all bets are off. The entire second half becomes a brutal gauntlet where you really need to know what you're doing if you don't want your hearts to quickly dwindle down to zero.

Speaking of zero hearts, I tried playing this with no hearts and I got as far as Francis's last phase before I finally got hit and died. If you're insane (or crazy, or ludicrous, or freaky) enough to attempt the Hard Mode No Hearts Boss Rush challenge and actually win, hats off to you.