US 340 - (Virginia) US 277 to VA 50 Northbound

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U.S. Route 340 (US 340) is a spur route of US 40, and runs from Greenville, Virginia to Frederick, Maryland. In Virginia, it runs north–south, parallel and east of US 11, from US 11 north of Greenville via Waynesboro, Grottoes, Elkton, Luray, Front Royal, and Berryville to the West Virginia state line. A short separate piece crosses northern Loudoun County on its way from West Virginia to Maryland.

In West Virginia, it runs north–south in Jefferson County, between Clarke County, Virginia and Loudoun County, Virginia. It is the main route between Charles Town and Harpers Ferry, and it is known as the William L. Wilson Freeway through that stretch. The southern portion of the highway, between the Virginia state line and Charles Town, is known as Berryville Pike.