| 1. | Doctor Fact-Checks PLANDEMIC Conspiracy | 78,880 | |
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| 2. | My Response To Fatphobia Claims | 58,881 | |
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| 3. | Real Doctor Reacts to THE GOOD DOCTOR | Medical Drama Review | Doctor Mike | 58,562 | Review |
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| 4. | Doctor Reacts to Middle Ground: Pro-Vaccine vs Anti-Vaccine | 57,715 | |
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| 5. | My 2018 Rewind + iPad Giveaway! | Gold Play Button Reveal | Doctor Mike | 54,188 | |
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| 6. | Real Doctor Reacts to GREY'S ANATOMY | Medical Drama Review | Doctor Mike | 46,136 | Review |
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| 7. | Doctor Fact-Checks Media On Coronavirus | 36,413 | |
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| 8. | The Truth About Cracking Your Knuckles | Responding to Comments #15 | 34,677 | |
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| 9. | Real Doctor Reacts to HOUSE M.D. | Medical Drama Review | Doctor Mike | 33,288 | Review |
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| 10. | Doctor Reacts to: FUNNIEST MEDICAL MEMES! | 32,186 | Review |
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| 11. | Doctor Plays Plague Inc. | The Ultimate Bacteria! | Wednesday Checkup | 30,292 | Let's Play | Plague Inc.
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| 12. | The Truth About The Coronavirus (Jan 2020) | 30,244 | |
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| 13. | My Thoughts On Vaping + ASMR | Responding to Your Comments | Doctor Mike | 27,309 | |
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| 14. | Real Doctor Reacts to CELLS AT WORK (Hataraku Saibō) | 25,421 | |
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| 15. | Doctor Reacts to Silly Medical Memes #6 | 24,987 | Review |
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| 16. | Real Doctor Reviews Minecraft Hospital Builds | 23,856 | Review | Minecraft
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| 17. | Real Doctor Reacts to "Adam Ruins the Hospital" | 23,485 | Review |
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| 18. | The Harsh Reality Of Being 800 Pounds | Doctor Reacts | 23,347 | |
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| 19. | The TRUTH About Swallowing Gum | Responding To Comments #16 | 23,244 | |
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| 20. | Ranking The MOST Accurate Medical Dramas | Dr. Mike | 22,937 | Review |
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| 21. | Face to Face With Dr. Fauci | The Truth Is…”It’s Almost Over” | 22,356 | |
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| 22. | Airplane Medical Emergency | WE COULDN'T LAND! | Wednesday Checkup | 22,316 | |
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| 23. | My Thoughts On Marijuana | Responding to Your Comments! | Doctor Mike | 22,097 | |
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| 24. | Doctor Reacts to RIDICULOUS Medical Memes #8 | 22,073 | Review |
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| 25. | Teen Boys Explain The Menstrual Cycle To A Doctor | Telephone Game | 21,801 | Show |
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| 26. | Kids Ask Awkward Health Questions! | Doctor Mike | 21,113 | |
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| 27. | That Vegan Teacher Roasts Me | 21,000 | |
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| 28. | TikTok Is Becoming Problematic | 20,267 | |
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| 29. | My Thoughts On Russia/Ukraine As A Russian Immigrant | 20,145 | |
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| 30. | Doctor Reacts To Bizarre Health "Hack" Videos | 20,018 | |
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| 31. | Doctor Mike Tries KETO for 30 DAYS | 19,660 | |
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| 32. | Roast Me For $1,000 | Doctor Mike | 19,542 | |
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| 33. | Doctor Reacts To Painful TikToks | 19,515 | |
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| 34. | The UPDATED Truth About The Coronavirus (Feb 2020) | 18,706 | Vlog |
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| 35. | Doctor Reacts to HOUSE M.D #2. | "Three Stories" | Medical Drama Review | 18,648 | Review |
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| 36. | Real Doctor Reacts to THE RESIDENT | Medical Drama Review | Doctor Mike | 18,332 | Review |
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| 37. | Doctor Reacts to Medical TikTok Controversy | 18,191 | |
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| 38. | Real Doctor Reacts to DOC MCSTUFFINS | 18,061 | |
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| 39. | Doctor Reacts To DRAMATIC Lifeguard Rescues | 18,018 | |
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| 40. | The Truth About COVID-19 Vaccines ft. Dr. Seema Yasmin | 17,938 | |
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| 41. | MEET MY BEAR PUPPY! | Health Benefits of Having a Dog | Doctor Mike | 17,869 | |
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| 42. | Doctor Reacts To Cringey Dhar Mann Videos | 17,792 | |
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| 43. | Doctor Reacts to Reckless Medical Memes #11 | 17,786 | Review |
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| 44. | How Often You Should Shower And Wash Hair | Responding To Comments Ep. 22 | 17,659 | Show |
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| 45. | Doctor Reacts to John Oliver | Last Week Tonight: Bias in Medicine | 17,604 | |
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| 46. | Doctor Reacts to AWKWARD TikToks | 17,110 | |
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| 47. | Doctor Reacts to: WILD MEDICAL MEMES EP. 3 | 16,901 | Review |
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| 48. | The TRUTH About Holding Your Pee | Responding to Comments | 16,789 | |
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| 49. | Doctor Reacts To The Most Strange Addictions | 16,619 | |
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| 50. | Doctor Reacts to HILARIOUS Medical Memes #9 | 16,575 | Review |
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| 51. | Doctor Reacts To Home Alone Injuries | 16,264 | |
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| 52. | The Part Of Your Body You Should NEVER Shave | RTC | 16,171 | |
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| 53. | What My Sister Really Thinks Of Me | Sibling Tag | 16,155 | |
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| 54. | Doctor Reacts To Ridiculous 5-Minute Crafts Videos | 16,099 | |
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| 55. | Real Doctor Reacts to CODE BLACK | Medical Drama Review | Doctor Mike | 15,991 | Review |
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| 56. | Law School vs. Med School: Which Is Harder? | 15,800 | |
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| 57. | The Most Shocking Bodies On TikTok | 15,739 | |
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| 58. | 50 Facts About Me | Doctor Mike | 15,584 | |
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| 59. | Here’s Why Trump’s COVID Diagnosis Was A Disaster | 15,558 | |
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| 60. | Doctor Says Gaming Is Healthy | 15,321 | |
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| 61. | Real Doctor Reacts to SCRUBS | Medical Drama Review | Doctor Mike | 15,311 | Review |
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| 62. | Coronavirus Is A PANDEMIC....Technically | 15,252 | |
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| 63. | How Often You Should Change Your Underwear | Responding To Comments | 15,233 | |
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| 64. | First Aid Hacks That Should Be Illegal | 15,085 | |
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| 65. | Doctor Fact-Checks President Trump On Coronavirus | 14,846 | |
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| 66. | Mark Rober's Dangerous Strategy On Hot Ones | 14,840 | |
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| 67. | We NEED More Testing Kits! | Coronavirus Front Line | 14,795 | |
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| 68. | Should Doctors Have Tattoos? | Responding to Your Comments #9 | Doctor Mike | 14,762 | |
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| 69. | Day In The Life Of A Doctor | My FIRST Hospital Vlog! | 14,543 | Vlog |
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| 70. | Here's Why Joe Rogan's COVID Treatment Is Problematic | 14,387 | |
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| 71. | Doctor Mike Goes VEGAN For 30 Days | Here's How My Body Reacted... | 14,356 | |
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| 72. | Real Doctor Reacts to GREY'S ANATOMY #2 | "Into You Like A Train" | 14,276 | Review |
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| 73. | Doctor Fact-Checks Grandma’s Medical Advice | 14,256 | |
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| 74. | Doctor Reacts to Priceless Medical Memes #7 | 14,214 | Review |
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| 75. | The Truth About Picking Your Nose | Responding To Comments #17 | 14,192 | |
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| 76. | Brad Mondo Roasts My Hairstyles & Styles My Hair | Dr. Mike | 14,070 | |
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| 77. | Doctor Reacts to BIZARRE Facebook Health Posts | 14,055 | |
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| 78. | Doctor Mike Interviews Dr. Fauci On COVID19 | 14,021 | |
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| 79. | Doctors React to Controversial Cosmo Cover | 13,977 | |
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| 80. | Real Doctor Reacts to THE GOOD DOCTOR #2 | Medical Drama Review | Doctor Mike | 13,936 | Review |
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| 81. | Doctor Reacts to Wacky Medical Memes #10 | 13,896 | Review |
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| 82. | The Thing About Vaccines... | Vaccine Controversies | Doctor Mike | 13,787 | |
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| 83. | Doctor Reacts to: ABSURD MEDICAL MEMES EP. 5 | 13,771 | Review |
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| 84. | Doctor Reacts To Triggering Medical Memes | 13,604 | |
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| 85. | Your Underwear EXPOSED! | Common Mistakes To Avoid | Doctor Mike | 13,523 | |
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| 86. | Doctor Reacts To Nickelodeon Medical Scenes | 13,338 | |
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| 87. | The Most Offensive Question I’m Asked As A Doctor | Dr. Mike | 13,206 | |
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| 88. | Doctor Reacts To Painful Medical Memes | 13,143 | |
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| 89. | Stop Drinking Hot Coffee & Tea | 13,054 | |
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| 90. | Ask Doctor Mike ft. GABBIE HANNA | Why's My Body Crooked? | 12,980 | Show |
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| 91. | Doctor Reacts To Awkward Medical Memes Ep. 16 | 12,738 | Review |
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| 92. | A Patient Filed A Complaint! | Wednesday Checkup | Doctor Mike | 12,712 | |
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| 93. | Doctor’s Trick to Stop A Bloody Nose | Responding To Comments | 12,680 | |
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| 94. | Doctor Reacts to: CRAZY MEDICAL MEMES EP. 4 | 12,617 | Review |
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| 95. | Doctor Reacts to: FUNNY MEDICAL MEMES EPISODE 2 | 12,613 | Show |
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| 96. | "Why Are My Hands Always Cold?" | Curbside Consult L.A. | 12,589 | |
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| 97. | Doctor Reacts To Memes That Are Actually Funny #13 | 12,491 | |
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| 98. | Doctor Reacts To Questionable Bear Grylls Survival Tips | 12,486 | |
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| 99. | Real Doctor Plays SURGEON SIMULATOR! | Wednesday Checkup | Doctor Mike | 12,402 | Let's Play | Surgeon Simulator
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| 100. | Doctor Reacts To The Worst TikTok Medical Advice | 12,221 | |
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