| 1. | A Heist with Markiplier REACTION | 22,394 | |
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| 2. | Madness Combat 11: Expurgation REACTION | 22,087 | |
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| 3. | My Jostens Ring Class Of 2014 Unboxing | 15,935 | |
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| 4. | Wilford 'MOTHERLOVING' Warfstache REACTION | 14,525 | |
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| 5. | CM Punk Chicago Kickpad Covers Unboxing | 12,336 | |
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| 6. | Markiplier & Lixian MEGA COMPILATION REACTION | 10,961 | |
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| 7. | Markiplier Animated | THE LEGEND OF BARBARA REACTION | 10,693 | |
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| 8. | Who Killed Markiplier? - The Final Chapter REACTION | 9,490 | |
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| 9. | New York Mets Alternate Pete Alonso Jersey Unboxing | 8,632 | |
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| 10. | Madness: Dedmos Adventure, episodes 1 - 5 REACTION | 8,168 | Show |
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| 11. | KILL JA̶CKSEPTICEYE Bio IN̵̛c Redemp T̨I̶̢on REACTION | 7,786 | |
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| 12. | WWEShop Unboxing #6 | 7,613 | |
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| 13. | CREEPYPASTA: Metroid Mother? | 7,608 | | Metroid
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| 14. | Who Killed Markiplier? - Chapter 1 REACTION | 7,573 | |
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| 15. | In Space with Markiplier: Part 2 REACTION | 7,006 | |
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| 16. | I GOT MY WISDOM TEETH REMOVED REACTION | 6,813 | |
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| 17. | WADE LITERALLY EXPLODES IN RAGE | UNO REACTION | 6,754 | |
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| 18. | DAMIEN REACTION | 6,468 | |
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| 19. | Try Not To Laugh Challenge #16 REACTION | 5,834 | |
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| 20. | Mark and Bob Bunk Their Beds REACTION | 5,727 | |
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| 21. | S̺͍͉͔͉̞̪Ḁ̸̰̮͝Y̶̪ ̳͇̭͍̥̭͉ͅG̕҉̡̦̲O̤̫͖͎̗͜͞ͅÒ̴̬̠̺̪̥͉̳͉̥͝D̨̺̦̯͙͙͔̯͚͠B̸̬̻̝͉͍̻̀͝Y҉̫̝̖̹̝̠͠E̲̩͟͝ͅ REACTION | 5,586 | |
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| 22. | In Space with Markiplier: Part 1 REACTION | 5,563 | |
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| 23. | Super Smash Bros. Trailers Live Reactions | 5,451 | | Super Smash Bros.
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| 24. | I CAN'T BREATHE!! | Google Feud #4 REACTION | 5,099 | | Google Feud
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| 25. | A Heist with Markiplier REACTION Part 3 | 5,009 | |
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| 26. | ONLY ~99 iQ INDIVIDUALS MAY WATCH REACTION | 4,922 | |
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| 27. | A Heist with Markiplier REACTION Part 2 | 4,905 | |
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| 28. | An Experiment REACTION | 4,554 | |
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| 29. | Batman Vs Superman Dawn Of Justice Trailer 3 REACTION | 4,004 | Preview |
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| 30. | Calling Carrie | 3,949 | |
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| 31. | Batman Vs Superman Dawn Of Justice Final Trailer REACTION | 3,895 | Preview |
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| 32. | John Cena 10 Years Strong Superfan Package Unboxing | 3,866 | |
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| 33. | A Heist with Markiplier | BLOOPERS REACTION | 3,658 | |
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| 34. | Who Killed Markiplier? - Chapter 2 REACTION | 3,440 | |
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| 35. | Who Killed Markiplier? - Behind the Scenes + Bloopers REACTION | 3,377 | |
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| 36. | Bob's Fridge Part 1 - Distractible Animated REACTION | 3,332 | |
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| 37. | CREEPYPASTA: Metroid 2 The Secret Worlds | 3,267 | | Metroid II: Return of Samus
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| 38. | Game Theory: The Secret Life of Markiplier REACTION | 3,244 | |
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| 39. | Wade Buys a Pregnancy Test REACTION | 3,193 | |
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| 40. | In Space with Markiplier | Official Trailer REACTION | 3,046 | Preview |
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| 41. | A DATE WITH MARKIPLIER REACTION | 3,018 | |
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| 42. | Markiplier Answers the Web's Most Searched Questions | WIRED REACTION | 3,017 | |
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| 43. | A Heist with Markiplier REACTION Part 4 | 2,990 | |
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| 44. | Who Killed Markiplier? - Chapter 3 REACTION | 2,988 | |
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| 45. | CREEPYPASTA: The Bowser and King Boo Theory | 2,980 | | Luigi's Mansion
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| 46. | Carrie Trailer 1 Live Reactions | 2,946 | Preview |
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| 47. | Reacting To Weird Irish Sex Education From The 80s REACTION | 2,943 | |
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| 48. | CHASE REACTION | 2,941 | |
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| 49. | ANOMALY FOUND - CHASE BRODY REACTION | 2,929 | |
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| 50. | Markiplier Alter Egos- Figaro REACTION | 2,923 | |
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| 51. | Star Wars The Force Awakens Trailer 3 REACTION | 2,827 | Preview |
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| 52. | Absolutely Awful ASMR REACTION | 2,825 | |
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| 53. | Samsung Flash Memory SD Camcorder Unboxing | 2,797 | |
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| 54. | Try Not To Laugh Challenge #13 REACTION | 2,758 | |
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| 55. | Madness Combat 9.5 part 1 REACTION | 2,753 | |
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| 56. | antisepticeye REACTION | 2,641 | |
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| 57. | Laughing Uncontrollably At Markiplier's MISERY | Phasmophobia REACTION | 2,629 | | Phasmophobia
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| 58. | Kevin Ware Leg Injury Live Reactions | 2,522 | |
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| 59. | Markiplier Makes: Creme Brulee REACTION | 2,499 | |
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| 60. | I Review Amazon Self Defense Products REACTION | 2,497 | Review |
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| 61. | Bloopers & Outtakes #3 (Jacksepticeye) REACTION | 2,449 | |
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| 62. | Good Ole Fashion Pumpkin Carve! REACTION | 2,449 | |
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| 63. | Bob's Fridge Part 2 - Distractible Animated REACTION | 2,446 | |
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| 64. | Batman Vs Superman Dawn Of Justice Comic Con Trailer REACTION | 2,422 | Preview | The Batman
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| 65. | DISSENTER REACTION | 2,415 | |
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| 66. | BEST OF Bob and Wade REACTION | 2,394 | |
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| 67. | EARTH SHATTERING RAGE!! | Pogostuck REACTION | 2,331 | | Pogostuck: Rage With Your Friends
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| 68. | Can You Figure Out Who DID IT? - Jameson Jackson's Jolly Jaunts REACTION | 2,318 | |
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| 69. | Avengers Age Of Ultron Teaser Trailer Reactions | 2,279 | Preview |
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| 70. | Try Not To Laugh Challenge #22 REACTION | 2,237 | |
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| 71. | I Bought the World's Brightest Flashlight REACTION | 2,230 | |
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| 72. | THIS WAS A MISTAKE... | Pogostuck #1 REACTION | 2,206 | | Pogostuck: Rage With Your Friends
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| 73. | Jacksepticeye Animated | Doki Doki Literature Club REACTION | 2,205 | | Doki Doki Literature Club!
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| 74. | Markiplier Animated - GIGGLYPLIER REACTION | 2,198 | |
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| 75. | Paranormal Activity: The Marked Ones Trailer Live Reactions | 2,197 | |
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| 76. | Batman Vs Superman Dawn Of Justice Teaser Trailer REACTION | 2,196 | | The Batman
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| 77. | Everyone Looks Like Markiplier... REACTION | 2,189 | |
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| 78. | BEST OF Markiplier Makes REACTION | 2,183 | |
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| 79. | Markiplier Makes: PIE REACTION | 2,144 | |
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| 80. | Markiplier Makes: An Egg Drop REACTION | 2,141 | |
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| 81. | How To Pole Dance 3 (feat. JackSepticEye) REACTION | 2,135 | Guide |
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| 82. | I LAUGH AT EVERYTHING | Jacksepticeye's Funniest Home Videos #3 REACTION | 2,083 | |
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| 83. | Sour Patch Kids ICE CREAM?! REACTION | 2,071 | |
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| 84. | Markiplier Makes: Dog Toys REACTION | 2,065 | |
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| 85. | Try Not To Laugh Challenge #20 REACTION | 2,055 | |
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| 86. | A Heist with Markiplier REACTION Part 5 | 2,053 | |
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| 87. | New York Mets Black Alternate Jersey Unboxing | 2,052 | |
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| 88. | CREEPYPASTA: A Dead Bart Update | 2,038 | Vlog |
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| 89. | Five Nights at Freddy's: Help Wanted - REACTION COMPILATION REACTION | 2,023 | Let's Play | Five Nights at Freddy's VR: Help Wanted
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| 90. | Unus Annus Founders T-Shirt Unboxing | 2,016 | |
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| 91. | Trying Korean, Russian, and American MREs REACTION | 1,998 | |
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| 92. | World's 5th Quietest Let's Play REACTION | 1,972 | Let's Play |
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| 93. | Reddit 50/50 CHALLENGE #3 REACTION | 1,968 | |
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| 94. | CREEPYPASTA: A Tape From Discovery/Treasure Island | 1,965 | |
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| 95. | Unus Annus Memes REACTION | 1,928 | Let's Play |
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| 96. | Perfectly Cut Screams REACTION | 1,927 | |
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| 97. | A Heist with Markiplier | BEHIND THE SCENES REACTION | 1,915 | |
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| 98. | Markiplier Tries: Tobii Eye Tracker REACTION | 1,914 | |
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| 99. | CM Punk AEW T-Shirt & Sticker Unboxing | 1,888 | |
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| 100. | Try Not To Laugh Challenge #18 REACTION | 1,863 | |
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