| 401. | Infamy - Item Guide - The Binding of Isaac: Rebirth | 4:09 | Guide | The Binding of Isaac: Rebirth
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| 402. | The Chocolate Milk BUFF nobody talks about! (Repentance) | 4:09 | | The Binding of Isaac: Rebirth
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| 403. | Isaac's Tomb - Item Guide - The Binding of Isaac: Repentance | 4:09 | Guide | The Binding of Isaac: Rebirth
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| 404. | Rare Giant Obstacles With Crazy Loot! | 4:08 | | The Binding of Isaac: Rebirth
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| 405. | 'M - Trinket Guide - The Binding of Isaac: Repentance | 4:08 | Guide | The Binding of Isaac: Rebirth
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| 406. | Monster Manual - Item Guide - The Binding of Isaac: Rebirth | 4:07 | Tutorial | The Binding of Isaac: Rebirth
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| 407. | Trash Cow Item! - Become Back your Money! (Mod) | 4:07 | | The Binding of Isaac: Rebirth
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| 408. | Caffeine Pill - Item Guide - The Binding of Isaac: Rebirth | 4:07 | Guide | The Binding of Isaac: Rebirth
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| 409. | Tooth and Nail - Item Guide - The Binding of Isaac: Repentance | 4:06 | Guide | The Binding of Isaac: Rebirth
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| 410. | The Infinite Ascent Loop! (New Game Break) | 4:06 | | The Binding of Isaac: Rebirth
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| 411. | Demon Baby - Item Guide - The Binding of Isaac: Rebirth | 4:05 | Guide | The Binding of Isaac: Rebirth
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| 412. | Molten Penny - FIEND FOLIO Trinket Guide - The Binding of Isaac Mod | 4:05 | Guide | The Binding of Isaac: Rebirth
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| 413. | The Binding Of Isaac: Shootout!!! (Quick Draw Mini-Game) | 4:05 | | The Binding of Isaac: Rebirth
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| 414. | Secret Joke Enemies - Fiend Folio Mod - The Binding of Isaac Afterbirth+ | 4:04 | | The Binding of Isaac: Rebirth
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| 415. | Juggernaut (Alternate Boss Theme) - The Binding of Isaac: Repentance OST (Pre-Release) | 4:04 | | The Binding of Isaac: Rebirth
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| 416. | You should use this Crooked Penny Trick! (Repentance) | 4:04 | | The Binding of Isaac: Rebirth
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| 417. | How To Get Infinite Items With Lost Soul! (Isaac Game Break) | 4:03 | | The Binding of Isaac: Rebirth
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| 418. | Lil Fiend - FIEND FOLIO Item Guide - The Binding of Isaac Mod | 4:01 | Guide | The Binding of Isaac: Rebirth
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| 419. | GMO Corn - FIEND FOLIO Item Guide - The Binding of Isaac Mod | 4:00 | Guide | The Binding of Isaac: Rebirth
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| 420. | Godhead, but as a playable Character! (Repentance Mod Showcase) | 4:00 | Show | The Binding of Isaac: Rebirth
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| 421. | Is the Shell Game Rigged? (Isaac Myth Busted) | 4:00 | | The Binding of Isaac: Rebirth
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| 422. | Distant Admiration - Item Guide - The Binding of Isaac: Rebirth | 3:59 | Guide | The Binding of Isaac: Rebirth
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| 423. | These BUFFED Items Synergize With Each Other! (Athame + My Shadow) | 3:59 | | The Binding of Isaac: Rebirth
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| 424. | Isaac Goes Rock Star!!! - Ridiculous Metal (Fiend Folio) | 3:58 | | The Binding of Isaac: Rebirth
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| 425. | Lucky Rock - Trinket Guide - The Binding of Isaac: Rebirth | 3:58 | Guide | The Binding of Isaac: Rebirth
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| 426. | The One Punch Man Item Build! - The Binding of Isaac: Repentance | 3:58 | | The Binding of Isaac: Rebirth
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| 427. | The Magnetic Nuke! (Tainted Eve + Epic Fetus + Strange Attractor) | 3:58 | | The Binding of Isaac: Rebirth
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| 428. | Fixed Boss Sprites and Changes in Patch 1.7.8a! (The Binding of Isaac Repentance) | 3:57 | | The Binding of Isaac: Rebirth
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| 429. | Echo Chamber STILL breaks the game! (Repentance Patch 1.7.7) | 3:56 | | The Binding of Isaac: Rebirth
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| 430. | Lucky Foot - Item Guide - The Binding of Isaac: Rebirth | 3:55 | Guide | The Binding of Isaac: Rebirth
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| 431. | Safety Scissors - Trinket Guide - The Binding of Isaac: Afterbirth | 3:54 | Guide | The Binding of Isaac: Rebirth
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| 432. | Rock Bottom + Soy Milk + Kidney Stone = 90 Tear Rate (totally balanced) | 3:53 | | The Binding of Isaac: Rebirth
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| 433. | Plum Flute - Item Guide - The Binding of Isaac: Repentance | 3:53 | Guide | The Binding of Isaac: Rebirth
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| 434. | Fissure (Mines Theme) - The Binding of Isaac: Repentance OST (Pre-Release) | 3:53 | | The Binding of Isaac: Rebirth
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| 435. | Mom's Lipstick - Item Guide - The Binding of Isaac: Rebirth | 3:53 | Guide | The Binding of Isaac: Rebirth
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| 436. | Item Quality - All Changes in the Patch. (Isaac Repentance) | 3:53 | | The Binding of Isaac: Rebirth
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| 437. | Mini Mush - Item Guide - The Binding of Isaac: Rebirth | 3:52 | Guide | The Binding of Isaac: Rebirth
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| 438. | Mom's Underwear - Item Guide - The Binding of Isaac: Rebirth | 3:51 | Guide | The Binding of Isaac: Rebirth
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| 439. | ╾━╤デ╦︻⊂(｡◕‿‿◕｡)つ | 3:50 | | The Binding of Isaac: Rebirth
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| 440. | Mom's Heels - Item Guide - The Binding of Isaac: Rebirth | 3:49 | Guide | The Binding of Isaac: Rebirth
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| 441. | You can play with multiple characters at once! (Repentance) | 3:49 | | The Binding of Isaac: Rebirth
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| 442. | Red Ribbon - FIEND FOLIO Trinket Guide - The Binding of Isaac Mod | 3:48 | Guide | The Binding of Isaac: Rebirth
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| 443. | The D10 Is Actually USEFUL Now!!! (Repentance Patch 1.7.9) | 3:47 | | The Binding of Isaac: Rebirth
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| 444. | The Sad Onion - Item Guide - The Binding of Isaac: Rebirth | 3:47 | Guide | The Binding of Isaac: Rebirth
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| 445. | I Found The Longest Piece Of Crap In Isaac! | 3:47 | | The Binding of Isaac: Rebirth
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| 446. | Doctor's Remote - Item Guide - The Binding of Isaac: Rebirth | 3:47 | Guide | The Binding of Isaac: Rebirth
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| 447. | My Shadow Is INSANE Now!!! (Repentance Patch 1.7.9) | 3:46 | | The Binding of Isaac: Rebirth
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| 448. | Paper Clip - Trinket Guide - The Binding of Isaac: Rebirth | 3:46 | Guide | The Binding of Isaac: Rebirth
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| 449. | Mew Cat Coins! | 3:46 | | The Binding of Isaac: Rebirth
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| 450. | The Final 2 Giant Obstacles Are Here! | 3:45 | | The Binding of Isaac: Rebirth
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| 451. | The CRAZIEST One Item Break In Isaac History!!! (Patch 1.7.9) | 3:45 | | The Binding of Isaac: Rebirth
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| 452. | Rosary - Item Guide - The Binding of Isaac: Rebirth | 3:44 | Guide | The Binding of Isaac: Rebirth
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| 453. | C Section OP...ONE Shot to kill every Boss in Isaac! | 3:44 | | The Binding of Isaac: Rebirth
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| 454. | This is how you REALLY break the Dummy in Repentance! | 3:44 | | The Binding of Isaac: Rebirth
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| 455. | Notched Axe - Item Guide - The Binding of Isaac: Rebirth | 3:43 | Guide | The Binding of Isaac: Rebirth
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| 456. | Tarnished Judas Synergy Teaser - Sinstone! | 3:43 | | The Binding of Isaac: Rebirth
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| 457. | Halo of Flies - Item Guide - The Binding of Isaac: Rebirth | 3:41 | Guide | The Binding of Isaac: Rebirth
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| 458. | The Bible - Item Guide - The Binding of Isaac: Rebirth | 3:41 | Guide | The Binding of Isaac: Rebirth
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| 459. | Deep Pockets - Item Guide - The Binding of Isaac: Afterbirth | 3:41 | Guide | The Binding of Isaac: Rebirth
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| 460. | This C Section Synergy creates an infinite Loop! | 3:40 | | The Binding of Isaac: Rebirth
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| 461. | 5 Boss Secrets That ALL Players Need To Know! (Repentance) | 3:39 | | The Binding of Isaac: Rebirth
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| 462. | Gehenna Got A New Boss! - Madomme (Fiend Folio) | 3:39 | | The Binding of Isaac: Rebirth
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| 463. | Store Credit - Trinket Guide - The Binding of Isaac: Rebirth | 3:38 | Guide | The Binding of Isaac: Rebirth
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| 464. | Adoption Papers - Trinket Guide - The Binding of Isaac: Repentance | 3:38 | Guide | The Binding of Isaac: Rebirth
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| 465. | All Item NERFS in Repentance Patch 1.7.9! | 3:37 | | The Binding of Isaac: Rebirth
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| 466. | You can Break Tainted Bethany with ONE Item! (Converter + Tainted Bethany) | 3:37 | | The Binding of Isaac: Rebirth
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| 467. | The Left Hand - Trinket Guide - The Binding of Isaac: Rebirth | 3:36 | Guide | The Binding of Isaac: Rebirth
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| 468. | Unfinished Bosses! Raglich and Clutch - The Binding of Isaac: Repentance | 3:34 | | The Binding of Isaac: Rebirth
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| 469. | Pageant Boy - Item Guide - The Binding of Isaac: Rebirth | 3:34 | Guide | The Binding of Isaac: Rebirth
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| 470. | You can play PvP in Isaac! - Repentance Possessor Mode | 3:34 | | The Binding of Isaac: Rebirth
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| 471. | This Synergy makes Tainted Lazarus Immortal! | 3:32 | | The Binding of Isaac: Rebirth
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| 472. | Spelunker Hat - Item Guide - The Binding of Isaac: Rebirth | 3:32 | Guide | The Binding of Isaac: Rebirth
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| 473. | Get infinite exploding Babies with this C Section Synergy! | 3:32 | | The Binding of Isaac: Rebirth
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| 474. | Mom's Bottle of Pills - Item Guide - The Binding of Isaac: Rebirth | 3:31 | Guide | The Binding of Isaac: Rebirth
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| 475. | Bucket of Lard - Item Guide - The Binding of Isaac: Rebirth | 3:31 | Guide | The Binding of Isaac: Rebirth
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| 476. | Cupid's Arrow - Item Guide - The Binding of Isaac: Rebirth | 3:31 | Guide | The Binding of Isaac: Rebirth
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| 477. | Only Pick 2 Of Them, NEVER All 3! (Isaac Anti-Synergy) | 3:31 | | The Binding of Isaac: Rebirth
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| 478. | Wire Coat Hanger - Item Guide - The Binding of Isaac: Rebirth | 3:31 | Guide | The Binding of Isaac: Rebirth
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| 479. | The New Athame is SO MUCH FUN!! (Repentance Patch 1.7.9) | 3:29 | | The Binding of Isaac: Rebirth
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| 480. | Blue Key - Trinket Guide - The Binding of Isaac: Repentance | 3:29 | Guide | The Binding of Isaac: Rebirth
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| 481. | This Suplex glitch can ONE-SHOT every boss! (Tainted Samson + Suplex!) | 3:28 | | The Binding of Isaac: Rebirth
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| 482. | Temporary Tattoo - Trinket Guide - The Binding of Isaac: Repentance | 3:28 | Guide | The Binding of Isaac: Rebirth
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| 483. | All Item Quality Changes in Patch 1.7.9! | 3:27 | | The Binding of Isaac: Rebirth
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| 484. | 2 Item Break for Infinite Angel Items! (NO SCHOOLBAG!) - The Binding of Isaac Repentance | 3:27 | | The Binding of Isaac: Rebirth
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| 485. | Guppy's Eye - Item Guide - The Binding of Isaac: Repentance | 3:26 | Guide | The Binding of Isaac: Rebirth
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| 486. | Infinite Angel Item Break! The Binding of Isaac Repentance | 3:23 | | The Binding of Isaac: Rebirth
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| 487. | The Hourglass - Item Guide - The Binding of Isaac: Rebirth | 3:23 | Guide | The Binding of Isaac: Rebirth
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| 488. | Ceremonial Robes - Item Guide - The Binding of Isaac: Rebirth | 3:22 | Guide | The Binding of Isaac: Rebirth
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| 489. | Dead Sea Scrolls - Item Guide - The Binding of Isaac: Rebirth | 3:22 | Guide | The Binding of Isaac: Rebirth
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| 490. | 2 Powerful Items In One - The Sacred Dice! | 3:21 | | The Binding of Isaac: Rebirth
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| 491. | Bacon Grease - FIEND FOLIO Item Guide - The Binding of Isaac Mod | 3:21 | Guide | The Binding of Isaac: Rebirth
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| 492. | Cool NEW Item Pool Discs!!! (Fiend Folio) | 3:20 | | The Binding of Isaac: Rebirth
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| 493. | Cain's Other Eye COPIES You Now! (Repentance Patch 1.7.9) | 3:19 | | The Binding of Isaac: Rebirth
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| 494. | Crystal Key - Trinket Guide - The Binding of Isaac: Repentance | 3:18 | Guide | The Binding of Isaac: Rebirth
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| 495. | The Bean - Item Guide - The Binding of Isaac: Rebirth | 3:18 | Guide | The Binding of Isaac: Rebirth
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| 496. | Isaac and Sissy dance for good Items!!! | 3:18 | | The Binding of Isaac: Rebirth
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| 497. | Infinite Forget Me Now Copy Trick! The Binding of Isaac Repentance | 3:18 | | The Binding of Isaac: Rebirth
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| 498. | Mom's Bra - Item Guide - The Binding of Isaac: Rebirth | 3:17 | Guide | The Binding of Isaac: Rebirth
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| 499. | Mom's Pad - Item Guide - The Binding of Isaac: Rebirth | 3:16 | Guide | The Binding of Isaac: Rebirth
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| 500. | Bertran + Mega Mush! Synergy Showcase (Mod) | 3:16 | Show | The Binding of Isaac: Rebirth
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