| 401. | NEVER SKIP BOSS RUSH!! || The Binding of Isaac Random Streak #182 | 38 | | The Binding of Isaac: Rebirth
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| 402. | Dark Power is Scary... | 38 | | The Binding of Isaac: Rebirth
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| 403. | J A I L | 38 | | The Binding of Isaac: Rebirth
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| 404. | The CREEPIEST Roguelike I've ever played... - Inscryption #1 | 38 | | Inscryption
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| 405. | Exploring EVERY RED ROOM - How I BROKE this New Character | 38 | | The Binding of Isaac: Rebirth
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| 406. | Unlocking TAINTED Fiend! - Fiend Folio | 38 | | The Binding of Isaac: Rebirth
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| 407. | Beating Three Final Bosses.... in one run. | 37 | | The Binding of Isaac: Rebirth
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| 408. | Double Poly-Brimstone VS Beast! || The Binding of Isaac Random Streak #166 | 37 | | The Binding of Isaac: Rebirth
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| 409. | [The Forgotten] THE BINDING OF ISAAC REPENTANCE FOUR PLAYER CO-OP FILE (35) | 37 | | The Binding of Isaac: Rebirth
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| 410. | What Terraria is like for Noobs ( Ft. @Keelvin , @heyn ) | 37 | | Terraria
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| 411. | How many runs does it it take to unlock EVERYTHING in Repentance? (Part 2/2) | 37 | | The Binding of Isaac: Rebirth
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| 412. | The ONE HEART Dream?!? - The Binding of Random Streaks #90 | 37 | | The Binding of Isaac: Rebirth
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| 413. | CAN INNER CHILD SAVE THIS RUN? - Random Streak 16 | 37 | | The Binding of Isaac: Rebirth
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| 414. | Tainted Lost VS MODDED Delirium... | 37 | | The Binding of Isaac: Rebirth
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| 415. | Breaking LIGHT SPEED With One Exploit... | 37 | | The Binding of Isaac: Rebirth
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| 416. | T. Forgotten Gets Gnawed Leaf and Sets Controller Down. (Free Win) | 36 | | The Binding of Isaac: Rebirth
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| 417. | The Binding of Isaac: Revelations | 36 | | The Binding of Isaac: Rebirth
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| 418. | How to Become INVINCIBLE As T. Maggy - Random Streak 36 | 36 | | The Binding of Isaac: Rebirth
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| 419. | EVERY Item Is DOUBLED, EVERY Enemy Is RANDOMIZED | 36 | | The Binding of Isaac: Rebirth
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| 420. | This Dice Room Breaks EVERY SINGLE RULE #shorts | 36 | | The Binding of Isaac: Rebirth
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| 421. | TBOI: Nuzlocke FINALE! - The Deleted SUPERCUT | 36 | | The Binding of Isaac: Rebirth
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| 422. | The Binding of Isaac PVP (Possesor Mode) | 36 | | The Binding of Isaac: Rebirth
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| 423. | The BEST Most USELESS Items of ALL TIME | 36 | | The Binding of Isaac: Rebirth
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| 424. | The Icy Pits of Hell Synergy | 36 | | The Binding of Isaac: Rebirth
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| 425. | We Shoot HOMING BRIM BALLS?? | 36 | | The Binding of Isaac: Rebirth
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| 426. | How to Contract a Cardiac Disease Playing Isaac pt. 2 | 36 | | The Binding of Isaac: Rebirth
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| 427. | The SINGLE Modded Item CARRY (Golden Champion's Belt) | 36 | | The Binding of Isaac: Rebirth
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| 428. | THE DEVIL RINGS OF DEATH || The Binding of Isaac Random Streaks #195 | 36 | | The Binding of Isaac: Rebirth
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| 429. | The "NECTAR OF THE GODS" Synergy | 36 | | The Binding of Isaac: Rebirth
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| 430. | Breaking Isaac to get a WORLD RECORD | 36 | | The Binding of Isaac: Rebirth
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| 431. | Worse Than TAINTED LOST?! - Random Streak 46 | 36 | | The Binding of Isaac: Rebirth
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| 432. | The MOST Stressful DAMOCLES pop YET... - Random Streak 22 | 36 | | The Binding of Isaac: Rebirth
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| 433. | BLOONS-D1P! | BTD6 Multiplayer | 36 | | Bloons TD 6
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| 434. | The BIGGEST RISK I've EVER TAKEN... Random Streak 52 | 36 | | The Binding of Isaac: Rebirth
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| 435. | 6 Little Guys, 72 BIG OL KNIVES! - Fiend Folio | 36 | | The Binding of Isaac: Rebirth
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| 436. | NEW Tainted Item Rooms and Devil Trapdoors! | 36 | | The Binding of Isaac: Rebirth
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| 437. | Basement One.. And Basement One... And Basement One... | 35 | | The Binding of Isaac: Rebirth
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| 438. | ICARUS - The Wax Winged MENACE! | 35 | | The Binding of Isaac: Rebirth
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| 439. | EGGS - The SECOND New Breakfast Character | 35 | | The Binding of Isaac: Rebirth
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| 440. | "What Would Jesus Do?" Challenge - Twitch Chat Challenge 2 | 35 | | The Binding of Isaac: Rebirth
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| 441. | OP "BLACK ICE" SYNERGY! || The Binding of Isaac Random Streak #176 | 35 | | The Binding of Isaac: Rebirth
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| 442. | Zach's BLESSED RED ROOM GAMBLING | 35 | | The Binding of Isaac: Rebirth
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| 443. | EDITH (Early Preview!) - Move By Teleporting! @teamcompliance2242 | 35 | | The Binding of Isaac: Rebirth
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| 444. | I gave up the RAREST active item for Crooked Penny... and live to regret it. - Eden Streak 12 | 35 | | The Binding of Isaac: Rebirth
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| 445. | Magic Skin is a Perfectly Balanced Item with No Issues - Random Streak 14 | 35 | | The Binding of Isaac: Rebirth
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| 446. | How Blood Oath can RUIN STREAKS || The Binding of Isaac Random Streak #177 | 35 | | The Binding of Isaac: Rebirth
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| 447. | RED KEY = E̴̻̎̔Ȓ̵̠̰̣̣͈̗͑̃͛̀R̵̨͕̥̟͓̝͖̂͒͘ͅŌ̴̥͔̇̓͌̀͒̇͗̑̕R̸͖̪͎͓̝͝ - The Binding of Random Streaks #84 | 35 | | The Binding of Isaac: Rebirth
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| 448. | Mei's Electric TECH IX RED MATTER SWIRL!! | 35 | | The Binding of Isaac: Rebirth
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| 449. | Becoming an Unstoppable Force in Isaac - Viewer Challenges 1 | 35 | | The Binding of Isaac: Rebirth
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| 450. | DOUBLE BERTRAN IS CHAOS!! (w/ Jokah) || The Binding of Isaac Modded Streak #249 | 34 | | The Binding of Isaac: Rebirth
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| 451. | I'm NEVER Doing This Again.... - The Binding of Random Streaks 76 | 34 | | The Binding of Isaac: Rebirth
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| 452. | MULTIPLAYER MODDED MASTEMA IS... STUPID || The Binding of Isaac Modded Streak #235 (ft Merm) | 34 | | The Binding of Isaac: Rebirth
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| 453. | The Most CLUTCH Mother Fight EVER - Four Player Isaac | 34 | | The Binding of Isaac: Rebirth
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| 454. | How This Build REVERSE SOFTLOCKED MOTHER! | 34 | | The Binding of Isaac: Rebirth
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| 455. | We Found Isaac's CRAZIEST BUG?! (Invincible forever?) | 34 | | The Binding of Isaac: Rebirth
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| 456. | THIS is what it’s like to have UNBEATABLE synergy in Isaac... | 34 | | The Binding of Isaac: Rebirth
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| 457. | First Floor Devil Deals are INSANE - Random Streak 3 | 34 | | The Binding of Isaac: Rebirth
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| 458. | CULT OF THE LAMB: The NEW Cult-Based Roguelike | 34 | | Cult of the Lamb
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| 459. | How Fast Can You Kill Beast?! #shorts | 34 | | The Binding of Isaac: Rebirth
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| 460. | The Ultimate Job Run. | 34 | | The Binding of Isaac: Rebirth
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| 461. | Can you unlock Samson in Multiplayer? | 34 | | The Binding of Isaac: Rebirth
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| 462. | Is R Key Isaacs BEST Item?!... [TBOI NUZLOCKE 5] | 34 | | The Binding of Isaac: Rebirth
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| 463. | Why Spirit Sword is secretly the BEST ITEM - Eden Streak 5 | 34 | | The Binding of Isaac: Rebirth
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| 464. | Planetarium Challenge Room (New Bosses) | 33 | | The Binding of Isaac: Rebirth
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| 465. | CAN TAINTED JACOB END THE STREAK?! - Random Streak 26 | 33 | | The Binding of Isaac: Rebirth
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| 466. | EXPLOITING The Game With One, Glitched Item. | 33 | | The Binding of Isaac: Rebirth
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| 467. | This Bug RUIN STREAKS!! || The Binding of Isaac Random Streaks 196 | 33 | | The Binding of Isaac: Rebirth
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| 468. | Is This The Greatest Re-Roll Of All Time? #shorts | 33 | | The Binding of Isaac: Rebirth
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| 469. | Isaac PROS teach two NOOBS how to play - Then we make them race (Part 2) (Uncut) | 33 | | The Binding of Isaac: Rebirth
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| 470. | Rock-Stone Knife-Bottom | 33 | | The Binding of Isaac: Rebirth
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| 471. | The April's Fool Challenge, but there's four of us | 33 | | The Binding of Isaac: Rebirth
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| 472. | R KEY ANARCHY (2x Items, 2x Runs) | 33 | | The Binding of Isaac: Rebirth
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| 473. | Can you Sacrifice in the Mirror World? (DOUBLE REWARDS?!) | 33 | | The Binding of Isaac: Rebirth
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| 474. | Extension Cord is BUSTED IN MULTIPLAYER! | 33 | | The Binding of Isaac: Rebirth
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| 475. | The STRONGEST Playable Enemy YET - Exorcist | 33 | | The Binding of Isaac: Rebirth
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| 476. | 310 reasons Bumbo is a bad item | 33 | | The Binding of Isaac: Rebirth
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| 477. | Modded 4 Player Isaac is Too Much. | 33 | | The Binding of Isaac: Rebirth
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| 478. | [Taking Dubs] FOUR PLAYER FILE - The Binding of Isaac Repentance part 3 | 33 | | The Binding of Isaac: Rebirth
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| 479. | What happens if you VOID R KEY and FORGET ME NOW... Then use it? | 32 | | The Binding of Isaac: Rebirth
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| 480. | I've never had a Tainted Lilith Run like THIS... Random Streak 4 | 32 | | The Binding of Isaac: Rebirth
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| 481. | MISSINGNO = DOUBLE GOD BLADE || The Binding of Isaac Modded Streak #240 | 32 | | The Binding of Isaac: Rebirth
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| 482. | What If Item Rooms Scaled With Luck? | 32 | | The Binding of Isaac: Rebirth
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| 483. | Golem VS Greedier - Fiend Folio | 32 | | The Binding of Isaac: Rebirth
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| 484. | The Binding of GREED-FOLIO! | 32 | | The Binding of Isaac: Rebirth
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| 485. | [ VIDEO LINK BLOCKED ] | 32 | | Deltarune
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| 486. | [Advancing] THE BINDING OF ISAAC REPENTANCE 4 PLAYER CO-OP (15) | 32 | | The Binding of Isaac: Rebirth
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| 487. | So, Tarnished Cain Just Released... | 32 | | The Binding of Isaac: Rebirth
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| 488. | This Boss Rush Challenge is NOT for Cowards - Fiend Folio The Gauntlet | 32 | | The Binding of Isaac: Rebirth
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| 489. | When Laz Rags are (almost) My Only Stats || The Binding of Isaac Repentance Random Streak #143 | 32 | | The Binding of Isaac: Rebirth
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| 490. | BERTRAN'S WRATH OF GOD VS MODDED BEAST | 32 | | The Binding of Isaac: Rebirth
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| 491. | 12 Broken Hearts as Tainted Lost #shorts | 32 | | The Binding of Isaac: Rebirth
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| 492. | Super Laser Tainted Cain - TECH 50 | 31 | | The Binding of Isaac: Rebirth
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| 493. | Tainted Pain. - Fiend Folio + | 31 | | The Binding of Isaac: Rebirth
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| 494. | Fiend Folio, But You Don't Choose Where To Move | 31 | | The Binding of Isaac: Rebirth
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| 495. | How to INFINITELY use bomb bums as Tainted Blue Baby (No Scissors!) | 31 | | The Binding of Isaac: Rebirth
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| 496. | Skipping EVERY Story Boss With ONE Item (Besides One...) | 31 | | The Binding of Isaac: Rebirth
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| 497. | How Techno-brosia BREAKS RUNS!! | 31 | | The Binding of Isaac: Rebirth
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| 498. | I am the Dream of Isaac. | 31 | | The Binding of Isaac: Rebirth
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| 499. | ALTAR FIEND SPEEDRUN | 31 | | The Binding of Isaac: Rebirth
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| 500. | This is the Worst Mod I've Ever Played | 31 | | The Binding of Isaac: Rebirth
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