| 301. | The TBOI: Nuzlocke is finally here | 46 | | The Binding of Isaac: Rebirth
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| 302. | P03 WORST Character, we STAN LESHY now! - Inscryption #11 | 46 | | Inscryption
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| 303. | "Guys, I'm not THAT Lucky" | 46 | | The Binding of Isaac: Rebirth
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| 304. | I am the worlds LUCKIEST Isaac player | 46 | | The Binding of Isaac: Rebirth
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| 305. | THE REAL JON CHALLENGE - Fiend Folio | 46 | | The Binding of Isaac: Rebirth
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| 306. | WHY DOES THIS EXIST #shorts | 46 | | The Binding of Isaac: Rebirth
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| 307. | Tainted Mutant Spider is OP | 46 | | The Binding of Isaac: Rebirth
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| 308. | PERFECTION IS PERFECTION!!! - The Binding of Random Streaks #87 | 45 | | The Binding of Isaac: Rebirth
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| 309. | Modded R Key is WAYYY Too Strong. | 45 | | The Binding of Isaac: Rebirth
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| 310. | DESTROYING with only ONE MODDED ITEM - The Rift | 45 | | The Binding of Isaac: Rebirth
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| 311. | HOW D100 CAN KILL A STREAK - "The Fettered" [20/34] The Binding of Isaac Iron Man Streakl | 45 | | The Binding of Isaac: Rebirth
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| 312. | ONE LIBRARY, FIFTEEN BOOKS || The Binding of Isaac Random Streak #185 | 45 | | The Binding of Isaac: Rebirth
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| 313. | From NOTHING to a FREE WIN... Random Streak 51 | 45 | | The Binding of Isaac: Rebirth
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| 314. | Tainted Item Rooms are Amazing | 45 | | The Binding of Isaac: Rebirth
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| 315. | Tainted Andromeda NEEDS To Be Nerfed... | 45 | | The Binding of Isaac: Rebirth
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| 316. | Azazel + Tech is CRAZY - TBOI NUZLOCKE | 45 | | The Binding of Isaac: Rebirth
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| 317. | Don't Shoot and You Win. | 45 | | The Binding of Isaac: Rebirth
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| 318. | Tainted Zach: A Gambler's NIGHTMARE! | 45 | | The Binding of Isaac: Rebirth
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| 319. | Isaac's TRUE Full Clear: Beating All 160 Red Rooms (Unseeded, No Debug) | 45 | | The Binding of Isaac: Rebirth
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| 320. | DOUBLE DAMAGE QUADRUPLE LASERS vs ETERNAL BEAST|| The Binding of Isaac Modded Streak #239 | 45 | | The Binding of Isaac: Rebirth
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| 321. | Soy Milk + 5 Spirit Swords is UNBEATABLE - Eden Streak 10 | 45 | | The Binding of Isaac: Rebirth
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| 322. | WE LOST IT ALL (I have an addiction)- The Binding Of Isaac Random Streak 58 | 45 | | The Binding of Isaac: Rebirth
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| 323. | We've Only got ONE SHOT TO WIN || The Binding of Isaac Random Streak #145 | 44 | | The Binding of Isaac: Rebirth
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| 324. | I teach my CHRISTIAN MOM how to play The Binding Of Isaac for Mothers Day. | 44 | | The Binding of Isaac: Rebirth
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| 325. | One SINGLE ROCK vs ETERNAL DELIRIUM || The Binding of Isaac Modded Streak #247 | 44 | | The Binding of Isaac: Rebirth
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| 326. | A Run So Strong, I Had to Use the DEBUG MENU!! | 44 | | The Binding of Isaac: Rebirth
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| 327. | MEI'S FLAMING SAWBLADE STORM | 44 | | The Binding of Isaac: Rebirth
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| 328. | The HOLY RESTOCK MACHINE SYNERGY! | 44 | | The Binding of Isaac: Rebirth
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| 329. | ETERNAL HUSH VS THE HOLY MEI SWEEP || The Binding of Isaac Modded Streak #236 | 44 | | The Binding of Isaac: Rebirth
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| 330. | I Broke The NEW Tarnished Judas... | 44 | | The Binding of Isaac: Rebirth
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| 331. | Making Isaac's EASIEST challenge even EASIER (sorta) | 44 | | The Binding of Isaac: Rebirth
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| 332. | Mastema's MEGA Dogma Tech VS Eternal Delirium | 43 | | The Binding of Isaac: Rebirth
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| 333. | R KEY: OUR LAST RESORT || The Binding of Isaac Random Streak #194 | 43 | | The Binding of Isaac: Rebirth
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| 334. | How Many Ways Are There to Destroy Gideon? | 43 | | The Binding of Isaac: Rebirth
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| 335. | THE HOLY HERETIC BUILD || The Binding of Isaac Random Streaks #174 | 43 | | The Binding of Isaac: Rebirth
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| 336. | The WORST thing to happen to a Streak... - Random Streak 41 | 43 | | The Binding of Isaac: Rebirth
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| 337. | Gaining 400 Damage from ONE FLOOR #shorts | 43 | | The Binding of Isaac: Rebirth
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| 338. | Floor one Devil Deals are OP! - Eden Streak 9 | 43 | | The Binding of Isaac: Rebirth
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| 339. | It Should NOT Have Been This Close... | TBOI NUZLOCKE | | 43 | | The Binding of Isaac: Rebirth
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| 340. | How Dark Prince's Crown SAVED my streak! - Eden Streak 7 | 43 | | The Binding of Isaac: Rebirth
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| 341. | The Alt Path in GREED MODE?! - The Binding of Isaac Repentance Mods | 43 | | The Binding of Isaac: Rebirth
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| 342. | Knock Out Drops + Soy Milk VERSUS Beast is HILARIOUS | 43 | | The Binding of Isaac: Rebirth
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| 343. | Three Repentance WORLD RECORDS back to back to back [Set Seed] | 43 | | The Binding of Isaac: Rebirth
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| 344. | Pushing Isaac to it's LIMITS WITH THIS RUN... - Random Streak 20 | 43 | | The Binding of Isaac: Rebirth
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| 345. | The Broken - You Can ONLY Shoot By MOVING | 43 | | The Binding of Isaac: Rebirth
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| 346. | THE DAMOCLES DISASTER - "The Curdled" [23/34] The Binding of Isaac Iron Man Streak | 43 | | The Binding of Isaac: Rebirth
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| 347. | The Busted DOUBLE Planetarium Keeper Run | 43 | | The Binding of Isaac: Rebirth
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| 348. | MAGIC MUSH MAYHEM || The Binding of Isaac Random Streak #183 | 43 | | The Binding of Isaac: Rebirth
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| 349. | TWO Planetarium Items on FLOOR ONE #shorts | 42 | | The Binding of Isaac: Rebirth
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| 350. | Every Item is BLIND, but ALWAYS High Quality! | 42 | | The Binding of Isaac: Rebirth
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| 351. | DOUBLE THE ITEMS, DOUBLE THE FEAR | 42 | | The Binding of Isaac: Rebirth
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| 352. | Double Twisted Pair + Chocolate Poly Brim CANNOT LOSE (30 BRIM SHOTS AT ONCE) - Random streak 15 | 42 | | The Binding of Isaac: Rebirth
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| 353. | MODDED Sacred Heart Synergies are BUSTED | 42 | | The Binding of Isaac: Rebirth
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| 354. | How to Turn Libraries into Item Rooms | 42 | | The Binding of Isaac: Rebirth
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| 355. | Turning into DOGMA With This ONE ITEM! | 42 | | The Binding of Isaac: Rebirth
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| 356. | HE CANT KEEP GETTING AWAY WITH IT - Random Streak 40 | 42 | | The Binding of Isaac: Rebirth
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| 357. | HUSH VS THE ULTIMATE BRAIN || The Binding of Isaac Random Streak #150 | 42 | | The Binding of Isaac: Rebirth
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| 358. | Pokemon X Binding of Isaac Character: EEVEE!! | 42 | | The Binding of Isaac: Rebirth
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| 359. | DA BIG MEGA STAN MELT - The Binding of Random Streaks #80 | 42 | | The Binding of Isaac: Rebirth
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| 360. | Why Para-Homing Brimstone SUCKS! || The Binding of Isaac Random Streak #180 | 42 | | The Binding of Isaac: Rebirth
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| 361. | Why SOUL OF LILITH Is SECRETLY The Strongest Pick Up in Isaac... | 42 | | The Binding of Isaac: Rebirth
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| 362. | Why Lilith may be the BEST character in Repentance | 42 | | The Binding of Isaac: Rebirth
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| 363. | "Fair and Balanced" #shorts | 41 | | The Binding of Isaac: Rebirth
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| 364. | The Most Unfair Modded Isaac Run In History | 41 | | The Binding of Isaac: Rebirth
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| 365. | 1 Fiend Run, 4 Final Bosses | 41 | | The Binding of Isaac: Rebirth
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| 366. | Playing "Delete This" In Fiend Folio | 41 | | The Binding of Isaac: Rebirth
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| 367. | Golem's Geodes VS Mother! - Fiend Folio | 41 | | The Binding of Isaac: Rebirth
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| 368. | Host Hat + Kamikaze is TOO GOOD... - Eden Streak 4 | 41 | | The Binding of Isaac: Rebirth
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| 369. | WHAT WERE THEY THINKING WITH ROCK BOTTOM?! - Random Streak 23 | 41 | | The Binding of Isaac: Rebirth
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| 370. | The POLYPHEMUS TEAR BREAK! || The Binding of Isaac Random Streak | 41 | | The Binding of Isaac: Rebirth
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| 371. | How to Win a Run with No Hands - Random Streak 31 | 41 | | The Binding of Isaac: Rebirth
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| 372. | SOUL OF LAZ IS THE STREAK SAVIOR?!? - The Binding of Isaac Random Streaks #94 | 41 | | The Binding of Isaac: Rebirth
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| 373. | Everything YOU Should know about ERROR ROOMS | 40 | | The Binding of Isaac: Rebirth
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| 374. | IMMORTAL WITH JUST ONE ITEM - Random Streak #32 | 40 | | The Binding of Isaac: Rebirth
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| 375. | The EASIEST Fiend Folio Challenge! - Isaac Rebuilt | 40 | | The Binding of Isaac: Rebirth
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| 376. | Beating 6 FINAL BOSSES... In One Run. || The Binding of Isaac Modded Streak #250 | 40 | | The Binding of Isaac: Rebirth
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| 377. | We unlocked BEAST before POLAROID - And why Extension Cord is BUSTED | 40 | | The Binding of Isaac: Rebirth
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| 378. | How My Modpack Corrupted My Save File | 40 | | The Binding of Isaac: Rebirth
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| 379. | Modded Greedier is STILL UNFAIR! | 40 | | The Binding of Isaac: Rebirth
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| 380. | 60 DAMAGE GODHEAD VS MEGA SATAN - The Binding of Random Streaks #68 | 40 | | The Binding of Isaac: Rebirth
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| 381. | Unlocking Tainteds BEFORE Samson - There's no way we can lose this run, right? | 39 | | The Binding of Isaac: Rebirth
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| 382. | QUAD SHOT + DOUBLE DAMMY || The Binding of Isaac Random Streak #179 | 39 | | The Binding of Isaac: Rebirth
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| 383. | THE TRUE GAME BREAK (Crashing 12 Times?!) || The Binding of Isaac Modded Streak #241 | 39 | | The Binding of Isaac: Rebirth
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| 384. | Timothy and the BETTER Crooked Penny! (110 items) | 39 | | The Binding of Isaac: Rebirth
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| 385. | THE GREEDIEST GAME BREAK EVER- "Azazel" [22/34] The Binding of Isaac Iron Man Streak | 39 | | The Binding of Isaac: Rebirth
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| 386. | Nineteen Planetarium Items, No Planetarium. | 39 | | The Binding of Isaac: Rebirth
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| 387. | How Fast Can You Beat "Speed" in Isaac? | 39 | | The Binding of Isaac: Rebirth
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| 388. | 12 MOM'S KNIVES!! || The Binding of Isaac Random Streak #193 | 39 | | The Binding of Isaac: Rebirth
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| 389. | Azazel's Red King INSANITY (Boss Room Trapdoors?) | 39 | | The Binding of Isaac: Rebirth
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| 390. | The WORST Possible Stats I've EVER Seen!! | 38 | | The Binding of Isaac: Rebirth
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| 391. | The CREEPIEST Roguelike I've ever played... - Inscryption #1 | 38 | | Inscryption
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| 392. | The Finale - The Binding of Isaac Repentance | 38 | | The Binding of Isaac: Rebirth
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| 393. | Unlocking TAINTED Fiend! - Fiend Folio | 38 | | The Binding of Isaac: Rebirth
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| 394. | SUPER SACRED CANDY HEART || The Binding of Isaac Random Streak #184 | 38 | | The Binding of Isaac: Rebirth
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| 395. | BERSERK SECTION SHREDS || The Binding of Isaac Random Streak #168 | 38 | | The Binding of Isaac: Rebirth
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| 396. | INFINITE EDEN'S BLESSINGS!!! || The Binding of Isaac Modded Streak #241 | 38 | | The Binding of Isaac: Rebirth
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| 397. | The ULTIMATE Shotgun BLAST! || The Binding of Isaac Random Streak #171 | 38 | | The Binding of Isaac: Rebirth
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| 398. | NEVER SKIP BOSS RUSH!! || The Binding of Isaac Random Streak #182 | 38 | | The Binding of Isaac: Rebirth
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| 399. | The D6, But BETTER?! (Flashing Lights Warning)- The Binding of Isaac Random Streaks #92 | 38 | | The Binding of Isaac: Rebirth
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| 400. | I Cheated to Save My Sanity. | 38 | | The Binding of Isaac: Rebirth
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