| 101. | These New Sacrifice Rooms Are Completely Broken! | 94 | |
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| 102. | This New Pill Gives You CRAZY Damage! | 143 | |
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| 103. | This New Silver Crown Gave Me Infinite Stats! | 96 | | The Binding of Isaac: Rebirth
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| 104. | New Way Of Unlocking Tarnished Judas Is Too Scary! | 104 | |
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| 105. | The Most Unexpected Gamebreak In Isaac History... | 73 | | The Binding of Isaac: Rebirth
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| 106. | This New Character Has Insane Sword Synergies! | 160 | |
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| 107. | This Reworked Golden Razor Gives Insane Damage! | 95 | |
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| 108. | This New Reworked Diplopia Is CRAZY! | 119 | |
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| 109. | This New Spoon Bender Brings Homing To The Next Level! | 229 | |
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| 110. | This New Character Has Crazy Abilities! Sin Gameplay! | 142 | | SiN
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| 111. | This New Character Has BROKEN Items! (Literally) | 118 | |
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| 112. | This New Transformation Is Too Horrifying! Epiphany Challenge #10 | 130 | |
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| 113. | Early Version Of Tainted Eden Is Extremely Glitched... | 124 | |
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| 114. | This New Item Almost Broke My Game! | 108 | |
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| 115. | This New Item Gave Me Every Quality 4 Possible! | 80 | |
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| 116. | This New Item Changes Your Tears With Giant Brimstone! | 111 | | The Binding of Isaac: Rebirth
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| 117. | This New Polyphemus Gave Me The Biggest Tears Ever! | 198 | |
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| 118. | Playable Santa Is Insanely Overpowered! | 86 | |
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| 119. | The Painful Truth About Tarnished Lost... | 149 | |
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| 120. | This New Guppy Transformation Changes Everything! | 89 | | The Binding of Isaac: Rebirth
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| 121. | I Broke World Record And Became The Richest Isaac Player! | 113 | | The Binding of Isaac: Rebirth
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| 122. | This New Playable Dead Isaac Is Insane! | 198 | | The Binding of Isaac: Rebirth
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| 123. | This New Item Gave Me Infinite Tears! | 143 | |
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| 124. | Isaac Online Is Finally Out! Getting New Achievements & More! | 92 | | The Binding of Isaac: Rebirth
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| 125. | This New Spider Character Is Too Toxic! | 105 | |
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| 126. | This New Isaac Transformation Is Literally CURSED! | 74 | | The Binding of Isaac: Rebirth
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| 127. | Money=Power Got A Huge Upgrade! It Gives Insane Damage! | 84 | |
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| 128. | All Isaac Transformations In One Run! | 115 | | The Binding of Isaac: Rebirth
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| 129. | Isaac Run, But Every Room I Get A New Character! | 79 | | The Binding of Isaac: Rebirth
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| 130. | Playing New Pure Isaac Is Extremely Fun! | 194 | | The Binding of Isaac: Rebirth
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| 131. | This New Item Gave Me The Best Familiars! | 74 | |
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| 132. | This New Character Has Craziest Items! Researcher Gameplay! | 201 | |
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| 133. | This New Technology Item Has Insane Synergies! | 128 | |
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| 134. | This New Character Has Electric Brimstone! Zoe Gameplay! | 149 | | Brimstone
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| 135. | This New Character Can't Take ANY Items! | 131 | |
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| 136. | I Created My Own Immortal Mini Isaac Army! | 94 | | The Binding of Isaac: Rebirth
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| 137. | They Added A New Beggar To The Game! He's Hilarious! | 168 | |
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| 138. | This New Item Turns Everything Into GOLD! | 125 | | The Binding of Isaac: Rebirth
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| 139. | The Craziest Character Ever Made! Tarnished Blue Baby Gameplay! | 93 | |
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| 140. | They Made Delirious Isaac. He's literally BROKEN! | 149 | | The Binding of Isaac: Rebirth
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| 141. | They Added New Technology Item! It's Extremely Powerful! | 80 | |
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| 142. | How I Shot Giant Rockets As Tainted Lost! | 79 | |
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| 143. | I Tried The Darkest Challenge In Isaac! | 74 | | The Binding of Isaac: Rebirth
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| 144. | I Tried Best Multishot Item In The Game! It's CRAZY! | 86 | |
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| 145. | I Tried The Most Intense Challenge In Isaac History... | 58 | | The Binding of Isaac: Rebirth
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| 146. | Jacob And Esau Run, But Only One Takes All The Items! | 60 | |
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| 147. | This New Character Gets The WORST Items Only! Tainted Bandit Gameplay! | 114 | | Bandits
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| 148. | Tainted Adam Is Finally Out! He's Extremely BROKEN! | 137 | |
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| 149. | I Found The Best Familiar In The Game! It's CRAZY! | 89 | | The Binding of Isaac: Rebirth
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| 150. | This New Cursed Room Gave Me The Best Items! | 115 | |
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| 151. | This New Golden Mushroom Gives INSANE Stats! | 178 | | The Binding of Isaac: Rebirth
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| 152. | They Made Playable Duke Of Flies! It's Extremely Cute! | 120 | |
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| 153. | This New Tainted Character Is Extremely Hard... | 164 | |
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| 154. | I Finally Achieved Giga Luck In Isaac! | 97 | | The Binding of Isaac: Rebirth
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| 155. | Playable Blood Donation Machine Is Too Horrifying! | 553 | | The Binding of Isaac: Rebirth
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| 156. | This New Quality 4 Item Gives INSANE Damage! | 139 | |
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| 157. | They Turned Slot Machine Into A Character?! It's INSANE! | 154 | | The Binding of Isaac: Rebirth
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| 158. | This New Damocles Sword Is Extremely Risky... | 231 | | Damocles
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| 159. | This New Upgraded Sacred Orb Is INSANE! | 110 | |
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| 160. | This New Rune Gives Craziest Stats Ever! | 82 | | The Binding of Isaac: Rebirth
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| 161. | Champion Lost Is Extremely Hard... | 71 | | The Binding of Isaac: Rebirth
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| 162. | This New Character Has CRAZY Synergies! Sheriff Gameplay! | 85 | | Sheriff
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| 163. | Best Ludovico Synergy? Cain to Mother | 9 | | The Binding of Isaac: Rebirth
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| 164. | The Razor Queen! Eve to Mother | 11 | | The Binding of Isaac: Rebirth
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| 165. | A Wrong Choice? Lilith's Glitched (Cursed) Crown! | 11 | | The Binding of Isaac: Rebirth
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| 166. | This is getting too tough... Tainted Lost to Mother (behind the scenes) | 11 | | The Binding of Isaac: Rebirth
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| 167. | This New Character Has The Craziest Stats! Adam Gameplay! | 123 | | The Binding of Isaac: Rebirth
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| 168. | True immortality??? Tainted Lost to Mother #5 | 11 | | The Binding of Isaac: Rebirth
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| 169. | HUGE SWORD! Tainted Lilith mega insane run! | 12 | | The Binding of Isaac: Rebirth
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| 170. | What can I get? Tainted Azazel chaos start! | 12 | | The Binding of Isaac: Rebirth
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| 171. | INFINITE REROLLS? Tainted Bethany madness! | 12 | | The Binding of Isaac: Rebirth
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| 172. | MEGA MUSH! Tainted Lost to Mother #6 | 12 | | The Binding of Isaac: Rebirth
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| 173. | Is this combo actually good? Cain to Satan | 12 | | The Binding of Isaac: Rebirth
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| 174. | 3 Planetarium Items in 1 Run! My Isaac broke the game! | 13 | | The Binding of Isaac: Rebirth
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| 175. | GOODBYE BITRATE! Tainted Isaac PC-breaking run! | 13 | | The Binding of Isaac: Rebirth
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| 176. | This Mod Adds New Planetariums With Bosses! | 93 | | The Binding of Isaac: Rebirth
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| 177. | Satisfying brimstone! Judas to Lamb | 13 | | The Binding of Isaac: Rebirth
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| 178. | SPRAY DOWN THE BOSS!!! | 14 | | The Binding of Isaac: Rebirth
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| 179. | Cheating with Glowing Hour Glass! Jacob and Esau to Delirium! | 14 | | The Binding of Isaac: Rebirth
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| 180. | The Perfect Ending! Tainted Lost to Mother #10 | 14 | | The Binding of Isaac: Rebirth
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| 181. | LOW HP FLEX! Tainted Maggy insane run! | 14 | | The Binding of Isaac: Rebirth
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| 182. | 1000 FETUSES PER SECOND! Insane Meme Run! (Gone wrong) | 15 | | The Binding of Isaac: Rebirth
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| 183. | I Got Huge Lasers! Tainted Lost's Electric Run! | 15 | | The Binding of Isaac: Rebirth
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| 184. | I'll never get this lucky again! Tainted keeper free win start (gone wrong) | 15 | | The Binding of Isaac: Rebirth
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| 185. | This run is deliriously good! Cain to Delirium | 15 | | The Binding of Isaac: Rebirth
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| 186. | Tainted Lost to Beast: ELECTRO RAVE | 15 | | The Binding of Isaac: Rebirth
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| 187. | 20X Brimstone Ring Shot! Satisfying Tainted Isaac Run! | 16 | | The Binding of Isaac: Rebirth
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| 188. | ONE ITEM WIN - LEMEGETON! Tainted Lost to Mother #7 | 16 | | The Binding of Isaac: Rebirth
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| 189. | ONE MILLION BRIMSTONES!!! Isaac To Delirium X3 | 16 | | The Binding of Isaac: Rebirth
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| 190. | Fetus Mega Splash! Eden Got The Luck! | 17 | | The Binding of Isaac: Rebirth
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| 191. | Luckiest Chaos So Far!? | 17 | | The Binding of Isaac: Rebirth
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| 192. | This Genesis Was Just Perfect! Tainted Lost To Mother! | 17 | | The Binding of Isaac: Rebirth
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| 193. | 100 LUCK RUN!!! Tainted Lost to Mother #9 | 17 | | The Binding of Isaac: Rebirth
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| 194. | This run just gone wrong... Apollyon to... | 17 | | The Binding of Isaac: Rebirth
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| 195. | This Item Gives Infinite Damage! My Craziest Tainted Eve Run! | 17 | | The Binding of Isaac: Rebirth
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| 196. | Damocles Mongo Gang! Tainted Lost to Mother #4 | 17 | | The Binding of Isaac: Rebirth
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| 197. | This Is Too Random For Me... Eden Reroll Madness! | 18 | | The Binding of Isaac: Rebirth
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| 198. | The hardest choice in my life! Tainted Lost to Mother #8 | 18 | | The Binding of Isaac: Rebirth
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| 199. | Incredible DMG boost! Tainted Lost to Mother #2 | 18 | | The Binding of Isaac: Rebirth
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| 200. | Shooting skittles! Eden to Delirium | 18 | | The Binding of Isaac: Rebirth
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