| 101. | The Binding of Isaac: Afterbirth+ (R068) [Lilith] | 48 | | The Binding of Isaac: Rebirth
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| 102. | Nub Plays The Binding of Isaac Afterbirth+ (R063) [HUSH] | 48 | Let's Play | The Binding of Isaac: Rebirth
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| 103. | Nub Plays Binding of Isaac: Afterbirth+ (R059-61) [Fetus] | 46 | Let's Play | The Binding of Isaac: Rebirth
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| 104. | The Binding of Isaac: Afterbirth+ (R085-87) [DESTRUCTION] | 45 | | The Binding of Isaac: Rebirth
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| 105. | THE WORST ROOM IN REPENTANCE? (The Binding of Isaac: Repentance) | 44 | | The Binding of Isaac: Rebirth
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| 106. | Nub Plays Binding of Isaac: Afterbirth+ (R052) [RAGE] | 44 | Let's Play | The Binding of Isaac: Rebirth
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| 107. | THE MOST CALCULATED BREAK IN ISAAC HISTORY! (The Binding of Isaac: Afterbirth+) | 42 | | The Binding of Isaac: Rebirth
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| 108. | The Binding of Isaac: Afterbirth+ (R091) [Sluggish] | 42 | | The Binding of Isaac: Rebirth
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| 109. | THIS IS HOW YOU ROLL YOUR DICE EFFECTIVELY! (The Binding of Isaac: Afterbirth+) | 42 | | The Binding of Isaac: Rebirth
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| 110. | NORTHERNLION!!!! (The Binding of Isaac: Afterbirth+) [105] | 42 | | The Binding of Isaac: Rebirth
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| 111. | DOUBLE HUSH? WHAT DOES IT MEAN? (The Binding of Isaac: Afterbirth+) | 41 | | The Binding of Isaac: Rebirth
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| 112. | The Binding of Isaac: Afterbirth+ (R094) [D20] | 41 | | The Binding of Isaac: Rebirth
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| 113. | THIS MAKES LILITH AN EASY MODE CHARACTER! (The Binding of Isaac: Afterbirth+) | 37 | | The Binding of Isaac: Rebirth
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| 114. | MARKED IS BUFFED? (The Binding of Isaac: Repentance) | 37 | | The Binding of Isaac: Rebirth
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| 115. | GOOFED!!! (The Binding of Isaac: Afterbirth+) [112] | 36 | | The Binding of Isaac: Rebirth
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| 116. | SNOT!!!!!! (The Binding of Isaac: Afterbirth+) [R097-98] | 34 | | The Binding of Isaac: Rebirth
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| 117. | THE FUNDAMENTALS! (The Binding of Isaac: Afterbirth+) | 34 | | The Binding of Isaac: Rebirth
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| 118. | THIS IS HOW YOU BEAT THE BEAST! (The Binding of Isaac: Repentance) | 34 | | The Binding of Isaac: Rebirth
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| 119. | JACOB AND ESAU ARE SO DIFFICULT! (The Binding of Isaac: Repentance) | 33 | | The Binding of Isaac: Rebirth
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| 120. | The Binding of Isaac: Afterbirth+ (R092-93) [Grind] | 32 | | The Binding of Isaac: Rebirth
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| 121. | NDP Streams The Binding of Isaac: Afterbirth+ [Birthday] | 32 | Let's Play | The Binding of Isaac: Rebirth
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| 122. | FORGOTTEN RUNS!!! (The Binding of Isaac: Afterbirth+) | 32 | | The Binding of Isaac: Rebirth
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| 123. | The Binding of Isaac: Afterbirth+ (R095) [RUINED] | 32 | | The Binding of Isaac: Rebirth
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| 124. | The Binding of Isaac: Afterbirth+ (R090) [LAMB] | 31 | | The Binding of Isaac: Rebirth
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| 125. | The Binding of Isaac: Afterbirth+ (R082) [POWERFUL] | 31 | | The Binding of Isaac: Rebirth
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| 126. | RAGEQUIT (The Binding of Isaac: Afterbirth+) (#128) | 31 | | The Binding of Isaac: Rebirth
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| 127. | The Binding of Isaac: Afterbirth+ (R096) [Sacred] | 31 | | The Binding of Isaac: Rebirth
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| 128. | How Is The New Tainted Cain? (The Binding of Isaac: Repentance) [Tainted Cain] | 31 | | The Binding of Isaac: Rebirth
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| 129. | DEFINITELY A WELL EARNED RUN! (The Binding of Isaac: Afterbirth+) | 30 | | The Binding of Isaac: Rebirth
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| 130. | DIRTY MIND (The Binding of Isaac: Repentance) | 30 | | The Binding of Isaac: Rebirth
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| 131. | Nub Streams The Binding of Isaac: Afterbirth+ [JUDAS] | 30 | | The Binding of Isaac: Rebirth
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| 132. | DOOMED (The Binding of Isaac: Afterbirth+) [128] | 29 | | The Binding of Isaac: Rebirth
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| 133. | MACHINE GUN TEARS! (The Binding of Isaac: Repentance) | 29 | | The Binding of Isaac: Rebirth
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| 134. | SOLAR SYSTEM (The Binding of Isaac: Afterbirth+) [131] | 28 | | The Binding of Isaac: Rebirth
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| 135. | Delete This Challenge, Complete (The Binding of Isaac: Repentance) | 28 | | The Binding of Isaac: Rebirth
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| 136. | FAR-FETCHED (The Binding of Isaac: Afterbirth+) [129] | 28 | | The Binding of Isaac: Rebirth
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| 137. | Falling Stalactites! (The Binding of Isaac: Repentance) | 28 | | The Binding of Isaac: Rebirth
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| 138. | IT'S FINALLY HERE! (The Binding of Isaac: Repentance) | 27 | | The Binding of Isaac: Rebirth
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| 139. | TRANCENDENT TECH X.5 (The Binding of Isaac: Repentance) | 27 | | The Binding of Isaac: Rebirth
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| 140. | TOO TOUGH FOR AZAZEL? (The Binding of Isaac: Repentance) | 27 | | The Binding of Isaac: Rebirth
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| 141. | AGAIN (The Binding of Isaac: Afterbirth+) [183] | 27 | Walkthrough | The Binding of Isaac: Rebirth
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| 142. | MY FIRST ISAAC CRASH! (The Binding of Isaac: Repentance) [Delete This Challenge Attempt 3] | 26 | | The Binding of Isaac: Rebirth
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| 143. | THIS IS THE WORST WAY TO END A BROKEN LILITH RUN! (The Binding of Isaac: Afterbrith+) | 26 | | The Binding of Isaac: Rebirth
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| 144. | THE GREATEST EDEN START OF ALL TIME??!! (The Binding of Isaac: Afterbirth+) | 26 | Walkthrough | The Binding of Isaac: Rebirth
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| 145. | ISAAC'S LAST HOPE! (The Binding of Isaac: Repentance) [Isaac] | 25 | | The Binding of Isaac: Rebirth
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| 146. | ALRIGHT ISAAC. FINE. (The Binding of Isaac: Afterbirth+) | 24 | | The Binding of Isaac: Rebirth
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| 147. | THE FORGOTTEN RUN (The Binding of Isaac: Afterbirth+) | 23 | | The Binding of Isaac: Rebirth
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| 148. | THERE ARE NO GOOD ITEMS IN ISAAC ANYMORE! (The Binding of Isaac: Repentance) | 23 | | The Binding of Isaac: Rebirth
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| 149. | SLOW ROLL (The Binding of Isaac: Afterbirth+) [160] | 23 | | The Binding of Isaac: Rebirth
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| 150. | The First Tainted Cain Run! (The Binding of Isaac: Repentance) | 23 | | The Binding of Isaac: Rebirth
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| 151. | MISERABLE (The Binding of Isaac: Afterbirth+) [162] | 22 | | The Binding of Isaac: Rebirth
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| 152. | That's Repentance+ Baby | 22 | | The Binding of Isaac: Rebirth
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| 153. | First Completed Post It Note Character in Repentance (The Binding of Isaac: Repentance) | 22 | | The Binding of Isaac: Rebirth
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| 154. | This made Tainted Judas Completely Broken (The Binding of Isaac: Repentance) | 21 | | The Binding of Isaac: Rebirth
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| 155. | BABY (The Binding of Isaac: Afterbirth+) [130] | 20 | Let's Play | The Binding of Isaac: Rebirth
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| 156. | I Haven't Been This Tilted In A While (The Binding of Isaac: Repentance) [Magdalene] | 20 | | The Binding of Isaac: Rebirth
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| 157. | Sacred Fly Army (The Binding of Isaac: Repentance) [Tainted Apollyon] | 20 | | The Binding of Isaac: Rebirth
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| 158. | Skip (The Binding of Isaac: Afterbirth+) [158] | 20 | | The Binding of Isaac: Rebirth
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| 159. | DEPRESSION!! (The Binding of Isaac: Afterbirth+) [119] | 20 | | The Binding of Isaac: Rebirth
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| 160. | INERTIA (The Binding of Isaac: Afterbirth+) [173] | 20 | Walkthrough | The Binding of Isaac: Rebirth
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| 161. | Ashpit (The Binding of Isaac: Repentance) [Bethany] | 19 | | The Binding of Isaac: Rebirth
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| 162. | COMPADRE (The Binding of Isaac: Afterbirth+) [139] | 19 | | The Binding of Isaac: Rebirth
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| 163. | UNLOCKING STUFF! (The Binding of Isaac: Repentance) | 19 | | The Binding of Isaac: Rebirth
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| 164. | SUICIDE KING (The Binding of Isaac: Afterbirth+) [132] | 18 | | The Binding of Isaac: Rebirth
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| 165. | Lost Runs (The Binding of Isaac: Repentance) | 18 | | The Binding of Isaac: Rebirth
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| 166. | I FINALLY BEAT GREEDIER AS CAIN! (The Binding of Isaac: Afterbirth+) | 18 | Walkthrough | The Binding of Isaac: Rebirth
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| 167. | Isaac Boi. We better than Northernlion (The Binding of Isaac: Afterbirth+) | 18 | | The Binding of Isaac: Rebirth
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| 168. | When in Doubt, Abyss Everything (The Binding of Isaac: Repentance) [Tainted Apollyon] | 18 | | The Binding of Isaac: Rebirth
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| 169. | PERHAPS I WAS OVERCONFIDENT? (The Binding of Isaac: Afterbirth+) | 17 | Walkthrough | The Binding of Isaac: Rebirth
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| 170. | Greatest Video Game Music of all Time: Fissure (Mines Theme) [The Binding of Isaac: Repentance] | 17 | | The Binding of Isaac: Rebirth
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| 171. | PURIST (The Binding of Isaac: Afterbirth+) [176] | 17 | | The Binding of Isaac: Rebirth
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| 172. | JAKE PAUL IN THE THUMBNAIL! | 17 | | The Binding of Isaac: Rebirth
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| 173. | THE ELUSIVE MAGIC MUSHROOM! (The Binding of Isaac: Repentance) [Tainted Judas] | 17 | | The Binding of Isaac: Rebirth
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| 174. | THE FAMILY MAN! (The Binding of Isaac: Afterbirth+) [178] | 17 | Walkthrough | The Binding of Isaac: Rebirth
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| 175. | AMIGOS (The Binding of Isaac: Afterbirth+) [155] | 16 | | The Binding of Isaac: Rebirth
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| 176. | Delete This Challenge Round 2 (The Binding of Isaac Repentance) | 16 | | The Binding of Isaac: Rebirth
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| 177. | AN EXPLOSIVE DOGMA RUN! (The Binding of Isaac: Repentance) | 16 | | The Binding of Isaac: Rebirth
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| 178. | Inertia (The Binding of Isaac: Afterbirth+) [148] | 16 | | The Binding of Isaac: Rebirth
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| 179. | COME ON EDMUND! PLEASE! (The Binding of Isaac: Repentance) | 16 | | The Binding of Isaac: Rebirth
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| 180. | It's In The Cards (The Binding of Isaac Afterbirth+) [159] | 16 | Walkthrough | The Binding of Isaac: Rebirth
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| 181. | MEGATILT (The Binding of Isaac: Afterbirth+) [154] | 16 | | The Binding of Isaac: Rebirth
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| 182. | THE ARMY OF MEAT BOYS! (The Binding of Isaac: Afterbirth+) | 16 | | The Binding of Isaac: Rebirth
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| 183. | Ask me absolutely anything as I Escape from a basement because Binding of Isaac | 16 | | The Binding of Isaac: Rebirth
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| 184. | ELECTRIC BRIMSTONE! (The Binding of Isaac: Repentance) [Judas] | 15 | | The Binding of Isaac: Rebirth
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| 185. | MISSING NO!!! (The Binding of Isaac: Repentance) [Tainted Azazel] | 15 | | The Binding of Isaac: Rebirth
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| 186. | THIS GAME IS CURSED! (The Binding of Isaac: Repentance) | 15 | | The Binding of Isaac: Rebirth
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| 187. | REROLL EXTRAVAGANZA! (The Binding of Isaac: Afterbirth+) | 15 | | The Binding of Isaac: Rebirth
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| 188. | POGTONIUM (The Binding of Isaac: Afterbirth+) [157] | 14 | | The Binding of Isaac: Rebirth
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| 189. | I AM SO MAD AT MYSELF (The Binding of Isaac: Afterbirth+) | 14 | | The Binding of Isaac: Rebirth
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| 190. | SHATTER (The Binding of Isaac: Afterbirth+) [174] | 14 | | The Binding of Isaac: Rebirth
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| 191. | Isaac: Crafting Game? (The Binding of Isaac: Repentance) [Tainted Cain] | 14 | | The Binding of Isaac: Rebirth
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| 192. | GOOD FUNDAMENTALS! (The Binding of Isaac: Afterbirth+) | 13 | | The Binding of Isaac: Rebirth
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| 193. | Brown Nugget Is Broken? (The binding of Isaac: Repentance) [Isaac] | 13 | | The Binding of Isaac: Rebirth
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| 194. | AGRESTAL (The Binding of Isaac: Afterbirth+) [142] | 13 | | The Binding of Isaac: Rebirth
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| 195. | PERTURBED (The Binding of Isaac Afterbirth+) [140] | 13 | | The Binding of Isaac: Rebirth
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| 196. | THE EPIC BETHANY RUN! (The Binding of Isaac: Repentance) [Bethany] | 13 | | The Binding of Isaac: Rebirth
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| 197. | BLUE BOMBER (The Binding of Isaac: Afterbirth+) [180] | 13 | | The Binding of Isaac: Rebirth
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| 198. | SHORTCOMING (The Binding of Isaac: Afterbirth+) [150] | 13 | | The Binding of Isaac: Rebirth
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| 199. | HYPERTILT (The Binding of Isaac: Afterbirth+) [171] | 13 | | The Binding of Isaac: Rebirth
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| 200. | IT'S EASY, JUST DON'T GET HIT! (The Binding of Isaac: Afterbirth+) | 13 | | The Binding of Isaac: Rebirth
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