| 201. | IT'S EASY, JUST DON'T GET HIT! (The Binding of Isaac: Afterbirth+) | 13 | | The Binding of Isaac: Rebirth
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| 202. | BLUE BOMBER (The Binding of Isaac: Afterbirth+) [180] | 13 | | The Binding of Isaac: Rebirth
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| 203. | Binding of Isaac Fun | 13 | | The Binding of Isaac: Rebirth
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| 204. | HYPERTILT (The Binding of Isaac: Afterbirth+) [171] | 13 | | The Binding of Isaac: Rebirth
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| 205. | GOOD FUNDAMENTALS! (The Binding of Isaac: Afterbirth+) | 13 | | The Binding of Isaac: Rebirth
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| 206. | SHORTCOMING (The Binding of Isaac: Afterbirth+) [150] | 13 | | The Binding of Isaac: Rebirth
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| 207. | I Just Can't Win (The Binding of Isaac: Repentance) [Blue Baby] | 12 | | The Binding of Isaac: Rebirth
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| 208. | TELEPORT (The Binding of Isaac: Afterbirth+) [137] | 12 | | The Binding of Isaac: Rebirth
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| 209. | SPRINKLER (The Binding of Isaac Afterbirth+) [153] | 12 | | The Binding of Isaac: Rebirth
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| 210. | FORGOTTEN! (The Binding of Isaac: Afterbirth+) [164] | 12 | | The Binding of Isaac: Rebirth
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| 211. | Cursed! (The Binding of Isaac: Afterbirth+) [135] | 12 | | The Binding of Isaac: Rebirth
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| 212. | Repentance Runs | 12 | | The Binding of Isaac: Rebirth
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| 213. | I WAS A MAD LAD WHO NEEDED TO STOP! (The Binding of Isaac: Afterbirth+) | 12 | Walkthrough | The Binding of Isaac: Rebirth
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| 214. | The First Tainted Maggie Run (The Binding of Isaac: Repentance) [Tainted Magdelane] | 12 | | The Binding of Isaac: Rebirth
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| 215. | DARKNESS FALLS!!! (The Binding of Isaac: Afterbirth+) [116] | 12 | | The Binding of Isaac: Rebirth
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| 216. | DAMAGE UPS DON'T EXIST ANYMORE (The Binding of Isaac: Repentance) [Tainted Judas] | 12 | | The Binding of Isaac: Rebirth
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| 217. | WHEN ISAAC TILTS YOU! (The Binding Of Isaac: Repentance) [Apollyon] | 12 | | The Binding of Isaac: Rebirth
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| 218. | THESE ARE HIGH LEVEL GAMER FOCUS HOURS! (The Binding of Isaac: Repentance) | 11 | | The Binding of Isaac: Rebirth
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| 219. | THE HARDEST CHARACTER TO GET TO DOGMA? (The Binding of Isaac: Repentance) [Lilith] | 11 | | The Binding of Isaac: Rebirth
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| 220. | COMPUTER SAVVY (The Binding of Isaac: Afterbirth+) [166] | 11 | | The Binding of Isaac: Rebirth
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| 221. | REMEMBER THE DEFINITION OF INSANITY? (The Binding of Isaac: Repentance) [Delete This Challenge] | 11 | | The Binding of Isaac: Rebirth
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| 222. | SIZEABLE (The Binding of Isaac: Afterbirth+) [138] | 11 | | The Binding of Isaac: Rebirth
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| 223. | Lord of the Flies (The Binding of Isaac: Repentance) [Tainted Apollyon] | 11 | | The Binding of Isaac: Rebirth
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| 224. | NO (The Binding Of Isaac: Afterbirth+) [182] | 11 | Walkthrough | The Binding of Isaac: Rebirth
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| 225. | OMISSION (The Binding of Isaac: Afterbirth+) [136] | 11 | | The Binding of Isaac: Rebirth
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| 226. | THE STRONGEST SAMSON GREEDIER RUN I'VE EVER HAD! (The Binding of Isaac: Afterbirth+) | 11 | | The Binding of Isaac: Rebirth
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| 227. | WE NEED MORE I-FRAMES! (The Binding Of Isaac: Repentance) | 11 | | The Binding of Isaac: Rebirth
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| 228. | THE MOST TOXIC AND GASSY RUN YOU WILL EVER SEE! (The Binding of Isaac: repentance) [The Forgotten] | 11 | | The Binding of Isaac: Rebirth
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| 229. | Few Isaac Runs Before Bed [The Binding of Isaac: Repentance] | 11 | | The Binding of Isaac: Rebirth
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| 230. | THE FAMILY MAN (The Binding of Isaac: Afterbirth+) [167] | 11 | | The Binding of Isaac: Rebirth
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| 231. | SOY (The Binding of Isaac: Afterbirth+) [170] | 11 | Walkthrough | The Binding of Isaac: Rebirth
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| 232. | IT ALL FELL APART! (The Binding of Isaac: Repentance) | 10 | | The Binding of Isaac: Rebirth
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| 233. | WAKA WAKA (The Binding of Isaac: Afterbirth+) | 10 | | The Binding of Isaac: Rebirth
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| 234. | SHARP STRAW! (The Binding of Isaac: Repentance) [Judas] | 10 | | The Binding of Isaac: Rebirth
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| 235. | FORFEIT (The Binding of Isaac: Afterbirth+) [161] | 10 | | The Binding of Isaac: Rebirth
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| 236. | Demo Man (The Binding of Isaac: Afterbirth+) [134] | 10 | | The Binding of Isaac: Rebirth
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| 237. | GETTING DISTRACTED (The Binding of Isaac: Afterbirth+) | 10 | | The Binding of Isaac: Rebirth
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| 238. | LOOK AT ME, NOT KNOWING MY CARDS! (The Binding of Isaac: Afterbirth+) | 10 | | The Binding of Isaac: Rebirth
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| 239. | IMPORTANT, PLEASE WATCH! (The Binding of Isaac: Repentance) [Delete This Challenge] | 10 | | The Binding of Isaac: Rebirth
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| 240. | DEVOID!!!! (The Binding of Isaac: Afterbirth+) [118] | 10 | | The Binding of Isaac: Rebirth
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| 241. | HARDSHIP (The Binding of Isaac: Afterbirth+) [147] | 9 | | The Binding of Isaac: Rebirth
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| 242. | Greedier is Impossible Now (The Binding of Isaac: Repentance) [Tainted Samson] | 9 | | The Binding of Isaac: Rebirth
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| 243. | Perpetual (The Binding of Isaac: Afterbirth+) [144] | 9 | | The Binding of Isaac: Rebirth
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| 244. | ONE OF THE FASTEST BEAST KILLS I HAVE HAD (The Binding of Isaac: Repentance) | 9 | | The Binding of Isaac: Rebirth
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| 245. | THE HARDEST CHARACTER IN REPENTANCE? (The Binding of Isaac: Repentance) [Tainted Eden] | 9 | | The Binding of Isaac: Rebirth
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| 246. | HITBOXES NEED FIXED (The Binding of Isaac: Repentance) [Tainted Eden] | 9 | | The Binding of Isaac: Rebirth
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| 247. | Painstaking (The Binding of Isaac: Afterbirth+) [165] | 9 | | The Binding of Isaac: Rebirth
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| 248. | ADHERE (The Binding of Isaac: Afterbirth+) [172] | 9 | Walkthrough | The Binding of Isaac: Rebirth
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| 249. | THE BIGGEST ANGEL ROOM PLAY EVER (The Binding of Isaac: Repentance) [The Lost] | 9 | | The Binding of Isaac: Rebirth
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| 250. | TEARS (The Binding of Isaac: Afterbirth+) [181] | 9 | | The Binding of Isaac: Rebirth
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| 251. | RUPTURED (The Binding of Isaac: Afterbirth+) [151] | 9 | | The Binding of Isaac: Rebirth
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| 252. | BETHANY.GET (The Binding of Isaac: Repentance) | 9 | | The Binding of Isaac: Rebirth
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| 253. | Ubiquitous (The Binding of Isaac: Afterbirth+) [149] | 9 | | The Binding of Isaac: Rebirth
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| 254. | I Almost Messed That Up! (The Binding of Isaac: Repentance) [Eve] | 8 | | The Binding of Isaac: Rebirth
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| 255. | Loop (The Binding of Isaac: Repentance) [Jacob & Esau] | 8 | | The Binding of Isaac: Rebirth
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| 256. | THE STRONGEST EDEN RUN IN REPENTANCE? (The Binding of Isaac: Repentance) | 8 | | The Binding of Isaac: Rebirth
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| 257. | GREEDY!!! (The Binding of Isaac: Afterbirth+) [117] | 8 | | The Binding of Isaac: Rebirth
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| 258. | OOPS! (The Binding of Isaac: Afterbirth+) [175] | 8 | | The Binding of Isaac: Rebirth
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| 259. | OOF (The Binding of Isaac: Afterbirth+) [163] | 8 | | The Binding of Isaac: Rebirth
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| 260. | INFINITE TRINKET COMBO (The Binding of Isaac: Repentance) [Bethany] | 8 | | The Binding of Isaac: Rebirth
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| 261. | Return to Isaac (Twitch Live Stream) [The Binding of Isaac: Afterbirth+] | 8 | | The Binding of Isaac: Rebirth
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| 262. | THE GAME DOESN'T WANT ME TO FINISH THIS CHALLENGE (The Binding of Isaac: Repentance) [Delete This] | 8 | | The Binding of Isaac: Rebirth
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| 263. | An Unfortunate Series of Events (Tainted Forgotten) [The Binding of Isaac: Repentance] | 8 | | The Binding of Isaac: Rebirth
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| 264. | TRIUMPH (The Binding of Isaac: Afterbirth+) [168] | 8 | | The Binding of Isaac: Rebirth
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| 265. | A TERRIBLE DECISION! (The Binding of Isaac: Repentance) [Tainted Lost] | 8 | | The Binding of Isaac: Rebirth
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| 266. | BLUNDER (The Binding of Isaac: Afterbirth+) [169] | 8 | | The Binding of Isaac: Rebirth
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| 267. | WAGER (The Binding of Isaac: Afterbirth+) [143] | 8 | | The Binding of Isaac: Rebirth
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| 268. | I MADE A MISTAKE (The Binding of Isaac: Repentance) [Tainted Eden] | 7 | | The Binding of Isaac: Rebirth
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| 269. | SHOPLIFTER (The Binding of Isaac: Afterbirth+) [145] | 7 | | The Binding of Isaac: Rebirth
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| 270. | AFFLICTION (The Binding of Isaac: Afterbirth+) [146] | 7 | | The Binding of Isaac: Rebirth
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| 271. | Serpent's Horny Tech (The Binding of Isaac: Repentance) [Apollyon] | 7 | | The Binding of Isaac: Rebirth
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| 272. | The First Tainted Samson Run (The Binding of Isaac: Repentance) [Tainted Samson] | 7 | | The Binding of Isaac: Rebirth
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| 273. | These Two Are The Worst (The Binding of Isaac: Repentance) [Jacob & Esau] | 7 | | The Binding of Isaac: Rebirth
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| 274. | WHEN ISAAC TROLLS YOU...... (The Binding of Isaac: Afterbirth+) | 7 | | The Binding of Isaac: Rebirth
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| 275. | UNLOCKING THE TWINS (The Binding of Isaac: Repentance) [Tainted Lilith] | 7 | | The Binding of Isaac: Rebirth
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| 276. | TERRIBLE!!! (The Binding of Isaac: Afterbirth+) [121] | 7 | | The Binding of Isaac: Rebirth
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| 277. | THE ABSOLUTE MOST BULLSH*T WAY TO DIE IN ISAAC AS THE LOST (The Binding of Isaac: Afterbirth+) | 7 | Walkthrough | The Binding of Isaac: Rebirth
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| 278. | I WAS SO CLOSE!!!!!! (The Binding of Isaac: Afterbirth+) | 7 | | The Binding of Isaac: Rebirth
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| 279. | THIS RUN IS BOMB AF (The Binding of Isaac: Repentnace) [Jacob And Esau] | 7 | | The Binding of Isaac: Rebirth
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| 280. | MAKING SOMETHING FROM NOTHING! (The Binding of Isaac: Repentance) [Tainted Judas] | 6 | | The Binding of Isaac: Rebirth
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| 281. | The Mines (The Binding of Isaac: Repentance) [The Lost] | 6 | | The Binding of Isaac: Rebirth
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| 282. | Pay to Play Attempt 1 (The binding of Isaac: Repentance) | 6 | | The Binding of Isaac: Rebirth
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| 283. | The Game Could Attempt To Play Nice at Least (The Binding of Isaac: Repentance) [Jacob & Esau] | 6 | | The Binding of Isaac: Rebirth
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| 284. | Anxiety Driven Run (The Binding of Isaac: Repentance) | 6 | | The Binding of Isaac: Rebirth
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| 285. | BUT I WAS ALMOST THERE! (The Binding of Isaac: Afterbirth+) | 6 | | The Binding of Isaac: Rebirth
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| 286. | THE FIRST TAINTED LAZARUS RUN (The Binding of Isaac: Repentance) [Tainted Lazarus) | 6 | | The Binding of Isaac: Rebirth
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| 287. | FIRST TAINTED LOST RUN! (The Binding of Isaac: Repentance) | 6 | | The Binding of Isaac: Rebirth
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| 288. | JUST ONE ROOM BREAKS A GREAT RUN! (The Binding of Isaac: Afterbirth+) | 6 | | The Binding of Isaac: Rebirth
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| 289. | Isaac Is Mean (The Binding of Isaac: Repentance) [Apollyon] | 6 | | The Binding of Isaac: Rebirth
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| 290. | DOWNHEARTED (The Binding of Isaac: Afterbirth+) [141] | 6 | Walkthrough | The Binding of Isaac: Rebirth
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| 291. | A GRAVE MISTAKE (The Binding of Isaac: Repentance) [Tainted Lost] | 6 | | The Binding of Isaac: Rebirth
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| 292. | THIS WAS A VERY STRANGE RUN! (The Binding of Isaac: Afterbirth+) | 6 | | The Binding of Isaac: Rebirth
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| 293. | Delete This Challenge Attempt X (The Binding of Isaac: Repentance) | 5 | | The Binding of Isaac: Rebirth
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| 294. | BETHANY'S BOOK COLLECTION (The Binding of Isaac: Repentance) [Bethany] | 5 | | The Binding of Isaac: Rebirth
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| 295. | THE FIRST TAINTED BETHANY RUN! (The Binding of Isaac: Repentance) [Tainted Bethany] | 5 | | The Binding of Isaac: Rebirth
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| 296. | Playdough Veins (The Binding of Isaac: Repentance) [Blue Baby] | 5 | | The Binding of Isaac: Rebirth
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| 297. | Troll Engine (The Binding of Isaac: Repentance) [Lilith] | 5 | | The Binding of Isaac: Rebirth
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| 298. | THE DOMINO EFFECT (The Binding of Isaac: Repentance) [Tainted Eden] | 5 | | The Binding of Isaac: Rebirth
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| 299. | Homing Eyeballs (The Binding of Isaac: Repentance) [Magdalene] | 5 | | The Binding of Isaac: Rebirth
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| 300. | BETHANY IS CURSED! (The Binding of Isaac: Repentance) [Bethany] | 5 | | The Binding of Isaac: Rebirth
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