| 1. |  OfficialNerdCubed | Nerd³ Plays... Comix Zone - The Page Master | 124,808 | Let's Play |
| 2. | whoisthisgit | Creepy Bad Endings # 20 | 122,582 | |
| 3. | Slope's Game Room | Comix Zone: The Complete History - SGR | 93,073 | |
| 4. | Top Hat Gaming Man | The MAD Story of COMIX ZONE - Why is it so Important!? – SEGA GAMING HISTORY | 45,291 | |
| 5. | Kim Justice | Chakan Review - Sega Genesis - Kimble Justice | 29,657 | Review |
| 6. | fusionhub86 | Sega Tunes: Comix Zone, Track 1: Into The Zone | 17,281 | |
| 7. | fusionhub86 | Sega Tunes: Comix Zone, Track 4: Seen It For Days | 11,205 | |
| 8. | fusionhub86 | Sega Tunes: Comix Zone, Track 5: Woe Is The World | 11,148 | |
| 9. | fusionhub86 | Sega Tunes: Comix Zone, Track 2: Feed My Disease | 10,146 | |
| 10. | Escape Route British | ERb :: Comix Zone Achievement Trick | 7,379 | |
| 11. | fusionhub86 | Sega Tunes: Comix Zone, Track 6: Last To Follow | 7,107 | |
| 12. | Tyrannicon | RETRO RAGE: Comix Zone (Genesis/Megadrive) | 6,202 | |
| 13. | AL82 Retrogaming Longplays | Comix Zone Longplay (Mega Drive/Genesis) [50 FPS] | 5,562 | |
| 14. | Vakantscull | COMIX ZONE May Be One Of The Worst Games I've Ever Played - REVIEW | 5,295 | Review |
| 15. | All Throws | Comix Zone (SEGA Genesis) Fighting Moves Demonstration - All Combos, Throws, Special Moves & Items | 4,743 | |
| 16. | TheLegendofRenegade | Comix Zone - Options (Into the Zone) (Sega Genesis Remix) | 4,739 | |
| 17. | TheLegendofRenegade | Comix Zone - Episode 1: Page 2-2 (Sega Genesis Remix) | 3,120 | Show |
| 18. | TheLegendofRenegade | Comix Zone - Episode 2: Page 1-3 (Last to Follow) (Sega Genesis Remix) | 2,407 | Show |
| 19. | TheLegendofRenegade | Comix Zone - Episode 3: Page 1-3 (Sega Genesis Remix) | 2,023 | Show |
| 20. | TheLegendofRenegade | Comix Zone - Episode 3: Page 2-1 (Sega Genesis Remix) | 1,939 | Show |
| 21. | Zeusdaz - The Unemulated Retro Game Channel | COMIX ZONE (MEGADRIVE / PS3 - FULL GAME - BAD ENDING) | 1,893 | |
| 22. | TheLegendofRenegade | Comix Zone - Episode 2: Page 2-1 (Sega Genesis Remix) | 1,707 | Show |
| 23. | Just Jamie Retro Realm | Mega Drive CD MSU/MD+ Super Enhanced Games [Time Stamps] #megadrive #megadrivegames #segamegadrive | 1,686 | |
| 24. | David William Beck (Wartorious) | Comix Zone (Megadrive) | 1,333 | |
| 25. | Retro Cheating :D | Retro Cheating :D #ComixZone #Megadrive #Sega #CheatCodes #Gaming #Gamer #Retro #CheatCodes #Genesis | 1,143 | |
| 26. | Retro Cheating :D | Retro Cheating :D #ComixZone #Megadrive #Sega #CheatCodes #Gaming #Gamer #Retro #CheatCodes #Genesis | 1,141 | |
| 27. | Scatigno | Comix Zone - PSN - Commentary | 1,057 | |
| 28. | Retro Cheating :D | Retro Cheating :D #ComixZone #Megadrive #Sega #CheatCodes #Gaming #Gamer #Retro #CheatCodes #Genesis | 973 | |
| 29. | Games Freezer | “Comix Zone Sega Genesis Ad (1995) The Comic Book Game That Punched Back!” #oldtvcommercials #sega | 878 | |
| 30. | CRT TV RETRO GAMER | Comix Zone Intro On A CRT TV #crt #retrogaming #sega #segagenesis | 763 | |
| 31. | Abraxas Arcadia | SEGA Mega Drive / Genesis Classics Challenge - Epic Comeback (Comix Zone) | 757 | |
| 32. | BIGGMILKY | The Chaos Engine - Greatest Video Game Soundtracks | 742 | |
| 33. | Chris Clarke | Comix Zone Cheat Sega Megadrive | 712 | |
| 34. | BIGGMILKY | MERCS - Forgotten Video Game Classics | 698 | |
| 35. | The Retro Hour (Retro Gaming Podcast) | 457: Comix Zone: Creating a Mega Drive Cult Classic - The Retro Hour EP457 | 688 | |
| 36. | VGM Hall of Fame | VGM Hall Of Fame: Comix Zone - Options | 666 | |
| 37. | HellfireComms | The HFC SEGAthon: A Marathon for the AGES! [#14: Comix Zone] | 661 | |
| 38. | Webster Likes Games | Comix Zone - Afr0Blu3's Retro View Episode 08 | 647 | |
| 39. | TheBigDaddyDReviews1 | Comix Zone | The Big Daddy D's Classic Game Reviews | 622 | Review |
| 40. | Retro Muel | Every Sega Mega Drive Beat em Up Ranked #12 | 621 | |
| 41. | SuperNerds UK | Comix Zone intro on the Sega Megadrive | 587 | |
| 42. | Genesis VII | SEGA Forever - Comix Zone | SEGA Forever Fridays | 579 | |
| 43. | andyukmonkey | Comix Zone - Song 1 - Episode 1-1 music - Megadrive (Real hardware) | 573 | Show |
| 44. | SPD64 | 𓆩✦𓆪SEGA'S UNDERRATED GEM𓆩✦𓆪 | Comix Zone | 538 | |
| 45. | Sega Head | 5 Games Better on Master System then NES/Famicom - Sega Head | 536 | |
| 46. | Kerr9000 | comic zone review | 530 | Review |
| 47. | PLAION UK | 5 Things You Need to Know About THE400Mini #the400mini #atari #retrogaming | 514 | |
| 48. | Classic From The Attic | Streets of rage trilogy. #retrogaming #sega #retro #16bit #streetsofrage #custom #megadrive | 473 | |
| 49. | Retro Cheating :D | Retro Cheating :D #AndrettiRacing #SegaSaturn #Sega #Saturn #Gaming #Retro #Gamer #CheatCodes #Sub | 419 | |
| 50. | Jesse Borondy | Comix Zone Teaser #drums #drumcover #drummer #comixzone #segagenesis #segamegadrive #teaser #metal | 410 | |
| 51. | GamebustersUK | Comix Zone Part 6 Final | 384 | |
| 52. | Funstock | Comix Zone (Mega Drive/Genesis) Gameplay on a Retron 5 in 720p HD | 377 | |
| 53. | PompeyGamesRoom | Pickups: New console & Game Cube, Switch, Megadrive, Saturn, Xbox 360 & PS3 additions | 356 | |
| 54. | Pyro Desire | Playing the games I loved growing up. Part 13. #sega #segagenesis #retrogaming #classicgaming | 356 | |
| 55. | Game on, boy! | Comix Zone Retro Review | 343 | Review |
| 56. | Retro Reach Around - Retro Gaming | Wait did he just Fart? Comix Zone Secret #retrogaming #sega #gamingeastereggs | 343 | |
| 57. | SEGA PIT | SEGA Critic: S1: Ep 23 - Comix Zone | 333 | |
| 58. | GamebustersUK | Comix Zone Part 5 | 323 | |
| 59. | SEGADriven.com | The Forgotten Comix Zone PC Port | 293 | |
| 60. | mariotaz | Comix Zone Playthrough (Achievements part 1) | 291 | Let's Play |
| 61. | Major Playerz | Playing Comix Zone with Greezy | 251 | |
| 62. | Know Your Games | Comix Zone: Episode 3 - Curse of the Dead Ships | 231 | Show |
| 63. | Genesis VII | MEGA DRIVE Monday | Comix Zone | Mark VII | 231 | |
| 64. | UK Gaming Network | 19 Racquet Sports games on Amiga RANKED | Retro Game Superleagues | 230 | |
| 65. | ScouseMouse | MORTUS COMES TO LIFE - Comix Zone | Part 1 | 214 | |
| 66. | lame gag | Comix Zone - SEGA Mega Drive / Analogue Mega SG Playthrough | 205 | Let's Play |
| 67. | Yorkshire gamer | comix zone megadrive #sega | 201 | |
| 68. | davpreec | Streets Of Rage Remake - Comix Zone - Playthrough | 201 | |
| 69. | davpreec | Streets Of Rage Remake - Comix Zone - Playthrough | 197 | |
| 70. | Sega Head | Comix Zone - Sega Head | 196 | |
| 71. | RUSHIAN RICHARD | SEGA Comix Zone ‐ European Megadrive vs US Beta version | A Comparison of the Intro + Episode 1 | 194 | Show |
| 72. | mariotaz | Comix Zone Playthrough (Achievements part 2) | 189 | Let's Play |
| 73. | The Legion | Escaping a COMIC BOOK WORLD! COMIX ZONE #1 (Sega Genesis) - DROP THE BOSS | 182 | |
| 74. | Paul Eales | Comix Zone (コミックスゾーン). [Mega Drive - Sega Technical Institute]. (1995). ALL. | 177 | |
| 75. | 128KB | Are These The Better JoyCon? | 173 | |
| 76. | Scott Tumilty | Comix Zone - Woe is the World (Cover) | 170 | |
| 77. | Know Your Games | Comix Zone: Episode 2 - Welcome to the Temple | 170 | Show |
| 78. | Alpha Chrome Yayo | Alpha Chrome Yayo - Comix Zone - Into The Zone [Cover] | 169 | Let's Play |
| 79. | StevieROM | Mercenaries 2 / PS3 / 2008 / Gameplay Highlights | 165 | |
| 80. | The Legion | WE ARE SQUISHY CAVEMEN! JOE & MAC GAMEPLAY (Sega Genesis) - DROP THE BOSS | 163 | |
| 81. | The Legion | THE FINAL BOSS! COMIX ZONE #5 (Sega Genesis) - DROP THE BOSS | 158 | |
| 82. | Classic From The Attic | Comix zone on the Sega mega drive #comixzone #retrogaming #sega | 156 | |
| 83. | Classic Retro Game Room | Lets Play Comix Zone For The Sega Megadrive Ultimate Collection Classic Retro Game Room | 152 | Let's Play |
| 84. | SuperNerds UK | Comix Zone on the sega megadrive | 151 | |
| 85. | The Legion | RATS ARE MORE USEFUL THAN YOU THINK! COMIX ZONE #3 (Sega Genesis) - DROP THE BOSS | 150 | |
| 86. | Njenkin | Comix Zone - SEGA Genesis / Mega Drive - with Commentary !! | 147 | |
| 87. | Scott Tumilty | Advent Calendar | 9 - Comix Zone | 146 | |
| 88. | Spawn300 | Mega Drive κουβέντα - Comix Zone Longplay attempt 1 - Halo TV Series Review | 143 | Review |
| 89. | The Legion | TEMPLE TOURNAMENT SCREAMS! COMIX ZONE #2 (Sega Genesis) - DROP THE BOSS | 139 | |
| 90. | Bare Buddies | Comix Zone - #1 - "What does the rat do?" - Bare Buddy | 133 | |
| 91. | Paul Eales | ビシバシスペシャル2. [PlayStation - Konami]. (1999). Full Play. | 129 | |
| 92. | John Gage | Comix Zone Review for the SEGA Mega Drive by John Gage | 128 | Review |
| 93. | Spawn300 | 100 Subs Special - Παίζουμε Mega Drive MONO! | 122 | |
| 94. | Retro Cheating :D | Comix Zone using a MegaDrive Cheat Code :D | 109 | |
| 95. | The Legion | DON'T GET STUCK IN THIS SLUDGE! COMIX ZONE #4 (Sega Genesis) - DROP THE BOSS | 108 | |
| 96. | SuperNerds UK | Comix Zone on the Sega Megadrive | 102 | |
| 97. | Retro Cheating :D | Retro Cheating :D #ComixZone #Megadrive #Sega #CheatCodes #Gaming #Gamer #Retro #CheatCodes #Genesis | 101 | |
| 98. | Deliverance84 | Night of the Mutants (COMIX ZONE) -EPISODE 1- Page 1-1 & Page 2-1 (Feed My Disease) 2025 D84 REMIX | 100 | |
| 99. | Bare Buddies | Comix Zone - #9 - "She's dead" - Bare Buddy | 100 | |
| 100. | GamebustersUK | Comix Zone Part 1 | 96 | |
