| 2025-06-05 | MAPP Ita | Mainframe one shot El estratega | 0:00 | 4 |
| 2025-05-12 |  Game8 | News & Reviews | mech warcrimes to commit and games to play | 0:00 | 349 |
| 2025-04-25 |  Wacky T. Bobcat | Mainframe Defenders gameplay | 0:00 | 34 |
| 2025-01-05 |  CarsonW518 | Mainframe Defenders Prologue Full | 0:00 | 15 |
| 2024-08-30 |  wildfremd | Mainframe Defenders #02: Die infizierte Anlage zerstören | 0:00 | 40 |
| 2024-08-29 | wildfremd | Mainframe Defenders #01: Klassisches Roguelike mit Mechs | 0:00 | 96 |
| 2024-08-25 | Lotaeri | Mainframe Defenders – Part 30 | Defending frames | 0:00 | 41 |
| 2024-08-24 | Lotaeri | Mainframe Defenders – Part 29 | The end nears | 0:00 | 32 |
| 2024-08-22 | Lotaeri | Mainframe Defenders – Part 28 | Advanced options | 0:00 | 39 |
| 2024-08-21 | Lotaeri | Mainframe Defenders – Part 27 | Tier Two | 0:00 | 50 |
| 2024-08-20 | Lotaeri | Mainframe Defenders – Part 26 | Manufacturing progress | 0:00 | 31 |
| 2024-08-19 | Lotaeri | Mainframe Defenders – Part 25 | Squad assemble! | 0:00 | 32 |
| 2024-07-05 |  変プレのみずちさん | 【単発】パーツ組み換えができるロボットSLG『メインフレーム・ディフェンダーズ』 | 48:01 | 5 |
| 2024-06-30 |  Hazen Koraka (Gaming) | Mainframe Defenders - Squad Based Roguelite Strategy - First Ever Run (Plus Tutorial) | 39:15 | 34 |
| 2024-03-28 | Ranmak | #hacker #robot #virus #fight #shorts #short #game #moments #игра #шортс #момент #arcade #битва #лайк | 0:13 | 276 |
| 2024-03-28 | Ranmak | Обзор игры Mainframe Defenders | 0:10 | 13 |
| 2024-03-09 | MOISTURE WORKS(もいわちゃん) - ゲーム実況 | #01【メインフレーム ディフェンダーズ】これは…ターン制ストラテジーゲーム？【ゲーム実況】 | 42:52 | 15 |
| 2023-10-18 | MilenioOscuro Games | MAINFRAME DEFENDERS ► Estrategia por Turnos y Robots │ Primer Vistazo en Español | 1:09:49 | 24 |
| 2023-05-05 | JouMxyzptlk | Mainframe Defender Version 1.3094a Endless mission bug | 16:31 | 70 |
| 2023-04-15 |  bad-sad | Mainframe Defenders - I screwed up, and yet I was half-successful :P | 27:07 | 28 |
| 2023-03-16 | Stellar | KOMPUTEROWI WOJOWNICY BRONIĄ PŁYTY GŁÓWNEJ! 👨🏻💻 - Mainframe Defenders PL | 31:04 | 23 |
| 2023-03-04 | Phantom | Main Frame Defenders 2 Mission Fall | 30:50 | 5 |
| 2023-03-04 | Phantom | Main Frame Defenders 1 Tutorial | 37:10 | 13 |
| 2023-01-23 | idleBot_deluxe | Mainframe Defenders, PC | 3:33:55 | 10 |
| 2023-01-14 | Mr. Delightful | CyberPunk Tactical Turn Based Terminator Mech Action! – MainFrame Defenders – #02 | 58:32 | 93 |
| 2023-01-09 | Mr. Delightful | Turn Based Tactics RPG Roguelike Wall Smashing SciFi Action! – MainFrame Defenders – #01 | 35:04 | 402 |
| 2023-01-07 | Scrambleking - Plays | Mainframe Defenders - P2 - A Hot Headed Tanks and Mistakes Being Made | 47:59 | 23 |
| 2023-01-07 | Scrambleking - Plays | Mainframe Defenders - P1 - Retro Turnbased Squad Fighter! | 1:47:24 | 25 |
| 2022-11-06 | げ | Mainframe Defenders | 9:21:35 | 7 |
| 2022-10-03 | RS-Type | Robot Fire Emblem | 9:23 | 18 |
| 2022-08-30 |  OverlordDen | Mainframe Defenders (9) | 3:19:40 | 10 |
| 2022-07-28 | PankRaru | Mainframe Defenders Ep.2 Hacker Voice "Im in" | 3:55:00 | 3 |
| 2022-07-20 | PankRaru | Mainframe Defenders Ep.1 "Into the Cyberverse" | 3:01:30 | 10 |
| 2022-06-26 | OverlordDen | Mainframe Defenders (8) | 4:08:20 | 24 |
| 2022-06-10 |  Nardyst | Mainframe Defenders Gameplay | 0:00 | 17 |
| 2022-06-04 | Dilgarno | 014：Mainflame Defenders / Speedrun | 1:12:29 | 9 |
| 2022-05-01 | 蔵上ケイン Kane Kuragami | 【Vtuber/ゲームプレイ/雑談】ゲーム再訪『メインフレームディフェンダーズ』 息抜きの為のウィルス退治【JP - EN/中文 OK】 | 51:36 | 14 |
| 2022-04-25 | Lotaeri | Mainframe Defenders – Part 25 | GG | 41:17 | 46 |
| 2022-04-22 | Lotaeri | Mainframe Defenders – Part 24 | Amazing equipment! | 50:50 | 46 |
| 2022-04-19 | Lotaeri | Mainframe Defenders – Part 23 | | 56:00 | 23 |
| 2022-04-16 | Lotaeri | Mainframe Defenders – Part 22 | Into the depths of Tier 2 | 53:26 | 30 |
| 2022-04-13 |  YYG | 主機保衛隊 非常困難 2022-04-13 全成就 END / Mainframe Defenders / 主机保卫队 | 3:53:44 | 74 |
| 2022-04-12 | Lotaeri | Mainframe Defenders – Part 21 | Adventuring forth! | 56:38 | 38 |
| 2022-04-10 | Lotaeri | Mainframe Defenders – Part 20 | Happy anniversary Mainframe Defenders! | 1:07:43 | 115 |
| 2022-03-30 | Dilgarno | 005：Mainflame Defenders / Speedrun | 1:48:37 | 5 |
| 2022-03-27 | Dilgarno | 004：Mainflame Defenders / Speedrun | 58:59 | 3 |
| 2022-03-18 | Dilgarno | 001：Mainflame Defenders / Speedrun | 1:37:41 | 121 |
| 2022-01-14 | Chemiczny_Spokój | Mainframe Defenders gameplay (PC)[HD](PL) | 15:17 | 70 |
| 2021-12-08 | StixsmasterHD | Mainframe Defenders First Playthrew Fun #1 | 24:13 | 7 |
| 2021-11-08 | InDepth Gaming! | Mainframe Defenders Gameplay on Xbox | 7:39 | 54 |
| 2021-11-03 | Headslayer_VODS | Mainframe Defenders - robots n shit | 5:27:03 | 17 |
| 2021-11-02 | GAMER GODS ASSEMBLE! | MAINFRAME DEFENDERS | 1:13:20 | 4 |
| 2021-11-02 | GAMER GODS ASSEMBLE! | MAINFRAME DEFENDERS | 21:39 | 1 |
| 2021-11-01 | GAMER GODS ASSEMBLE! | MAINFRAME DEFENDERS | 5:04:05 | 6 |
| 2021-10-28 |  PS5 PLANET | Mainframe Defenders - Official Trailer PS5 - | 1:10 | 432 |
| 2021-10-24 | EL RINCON DEL PETA TV | 📀*NEW GAME PS5* Mainframe Defenders | 1:10 | 30 |
| 2021-10-22 |  Game Trailers | Mainframe Defenders | Trailer (Nintendo Switch) | 0:52 | 149 |
| 2021-10-22 | ID@Xbox | Mainframe Defenders Xbox One Release Trailer | 0:56 | 444 |
| 2021-10-21 | Game on Linux | Mainframe Defenders: Meltdown Prologue episode | 9:36 | 7 |
| 2021-09-07 |  RoflLobster | S6E3 - Insane in the mainframe - Mainframe Defenders | 1:51:06 | 10 |
| 2021-09-06 | 蔵上ケイン Kane Kuragami | 【Vtuber/ゲーム紹介】『メインフレームディフェンダーズ』ウィルス退治戦略ゲームを改めて紹介【JP - EN/中文 OK】 | 3:31:10 | 419 |
| 2021-08-31 | AUS HESTOV | First Impression - Mainframe Defenders | 2:29:01 | 49 |
| 2021-08-23 | 蔵上ケイン Kane Kuragami | 【Vtuber/ゲームプレイ】「Mainframe Defenders」夏休み企画・旧ゲーム再訪その1【JP - EN/中文 OK】 | 2:56:25 | 57 |
| 2021-08-05 | Lotaeri | Mainframe Defenders – Part 19 | Mainframe Defended | 57:16 | 70 |
| 2021-08-03 | Lotaeri | Mainframe Defenders – Part 18 | Untouchable | 1:08:58 | 41 |
| 2021-08-01 | Lotaeri | Mainframe Defenders – Part 17 | The long arm-aments of the law | 1:11:07 | 40 |
| 2021-07-30 | Lotaeri | Mainframe Defenders – Part 16 | Tiering up the place | 54:41 | 34 |
| 2021-07-28 | Lotaeri | Mainframe Defenders – Part 14 | So this is what the Tau do eh? | 1:14:03 | 46 |
| 2021-07-26 | Lotaeri | Mainframe Defenders – Part 13 | Another call to arms | 57:00 | 62 |
| 2021-07-25 | SmartWargames | Mainframe Defenders Content Review & Gameplay | 23:31 | 271 |
| 2021-07-24 | Benadit | Mainframe Defenders: ¡La base de datos de virus, ha sido actualizada! | 56:03 | 134 |
| 2021-07-07 | Planetary engineer | Mainframe Defenders | 1:07:34 | 3 |
| 2021-07-04 | OverlordDen | Стрим по Mainframe Defenders от 04.07.21 (7) | 6:32:47 | 27 |
| 2021-06-25 | Lotaeri | Mainframe Defenders – Part 13 | Another end run (no commentary) | 1:05:09 | 55 |
| 2021-06-21 | OverlordDen | Стрим по Mainframe Defenders от 21.06.21 (6) | 4:45:43 | 12 |
| 2021-06-15 | Rumaruka | XCOMLIKE ИГРА ● Mainframe Defenders ● #ПутьБиблиотеки #108 | 11:16 | 36 |
| 2021-06-13 | OverlordDen | Стрим по Mainframe Defenders от 13.06.21 (5) | 3:41:39 | 17 |
| 2021-06-12 | OverlordDen | Стрим по Mainframe Defenders от 12.06.21 (4) | 4:45:49 | 11 |
| 2021-06-11 | 蔵上ケイン Kane Kuragami | 【Mainframe Defenders】レトロ戦略ゲーム・続編【JP - EN/中文 OK】 | 2:01:25 | 48 |
| 2021-06-07 | GamingOnLinux | Mainframe Defenders: Meltdown - Prologue (trailer) | 1:51 | 309 |
| 2021-06-03 | Sokol Free Channel | Mainframe Defenders: Meltdown - Prologue ★ Gameplay ★ PC Steam [ Free to Play ] Strategy Game 2021 | 12:46 | 67 |
| 2021-06-03 | どるどる | メインフレーム ディフェンダー Mainframe Defenders: Meltdown - Prologue 初見プレイ | 14:01 | 431 |
| 2021-05-21 | Зырк TV | Война машин [Mainframe Defenders] | 3:05:34 | 50 |
| 2021-05-12 | Lotaeri | Mainframe Defenders – Part 12 | Dominating (finale) | 48:39 | 83 |
| 2021-05-08 | Lotaeri | Mainframe Defenders – Part 11 | Run away! | 1:07:44 | 66 |
| 2021-05-06 | Lotaeri | Mainframe Defenders – Part 10 | Power Up | 1:17:39 | 71 |
| 2021-05-03 | Lotaeri | Mainframe Defenders – Part 9 | Raiders and Fabricators | 1:16:55 | 92 |
| 2021-05-03 | Draaven | Blind First Look - Mainframe Defenders (Live Stream) | 42:36 | 3 |
| 2021-04-30 | Lotaeri | Mainframe Defenders – Part 7 | Once more into the breach | 1:25:06 | 97 |
| 2021-04-24 | Lotaeri | Mainframe Defenders – Part 6 | United we stand, divided... | 1:03:32 | 117 |
| 2021-04-19 | Lotaeri | Mainframe Defenders – Part 5 | Early rewards paying off | 1:24:02 | 126 |
| 2021-04-16 | Lotaeri | Mainframe Defenders – Part 4 | Slow but steady | 1:21:26 | 116 |
| 2021-04-13 | Lotaeri | Mainframe Defenders – Part 3 | Time to Tier Two | 1:31:04 | 211 |
| 2021-04-10 | Lotaeri | Mainframe Defenders – Part 2 | Defending our frames | 1:41:45 | 377 |
| 2021-04-07 | Lotaeri | Mainframe Defenders – Part 1 | Choosing our mains | 1:54:26 | 1,783 |
| 2021-04-05 | RubberChicken TV | Indie X 2020 showcase of Mainframe Defenders | 45:11 | 28 |
| 2021-04-03 | Oathmaster | Trying out some Mainframe Defenders, Episode 3 | 1:44:15 | 37 |
| 2021-03-23 | Oathmaster | Trying out some Mainframe Defenders, Episode 2 | 2:28:51 | 45 |
| 2021-03-21 | Игро День | УСПЕЙ СКАЧАТЬ | MAINFRAME DEFENDERS | РАЗДАЧА КЛЮЧЕЙ STEAM! | 2:42 | 2,727 |
| 2021-03-18 | Oathmaster | Trying out some Mainframe Defenders, Episode 1 | 2:17:09 | 146 |
