| 1. |  Let's Play With Brigands | 314,074 | Maniac Mansion (Amiga Version | Full Playthrough) | 1:47:36 |
| 2. | PushingUpRoses | 198,031 | Let's Play: Maniac Mansion [part 10] with Roo (GOOD ENDING) | 17:30 |
| 3. | NintendoComplete | 14,750 | Maniac Mansion (NES) Playthrough | 3:10:36 |
| 4. | michael_stout79 | 10,465 | MANIAC MANSION Nintendo (NES) 1990 Game Play (EPISODE 1,072) Let's Play | 32:36 |
| 5. | Scribe | 3,128 | Let's Play Maniac Mansion (FINALE) - Night of the Tentacle | 32:23 |
| 6. | Kenshin1913 | 2,609 | Let's Play Maniac Mansion: Finale | 20:17 |
| 7. | Sensei Starman | 724 | Sensei Starman Plays Meteor Mess - The Michael and Syd Playthrough | 1:36:11 |
| 8. | ZetaPlays | 517 | Maniac Mansion (NES) - 02 - Summoning Space Police 27 Times | 33:18 |
| 9. | Wretch Plays | 407 | Let's Play Maniac Mansion - Part 2 | NES Wretch-rospective [Wretch Plays] | 36:05 |
| 10. | Marstead | 406 | ✔️️ Full Blind Playthrough (Maniac Mansion) | 4:01:25 |
| 11. | TehloneGamer | 392 | Let's Play Maniac Mansion: Part 5 | 15:53 |
| 12. | Famicom Dojo LIVE! | 308 | Planning a Heist - Sean Plays Maniac Mansion (NES), Part 4 | 1:32:34 |
| 13. | Video Games 101 | 223 | Maniac Mansion Playthrough | 4K 60FPS | Video Games 101 | 1:01:10 |
| 14. | VertigoTeaparty | 208 | Let's Play Maniac Mansion (Steam version) - Full game | 2:52:46 |
| 15. | 10 Minute Gamer | 203 | 10MG Plays Maniac Mansion on NES | 10:33 |
| 16. | RichCale | 202 | Maniac Mansion playthrough with commentary (3/3) | 27:38 |
| 17. | St. George's Games | 146 | Maniac Mansion: Chapter 2 - Don't Be A Tuna Head! | 1:01:15 |
| 18. | Geeks and Nerds | 121 | Pablo Plays - Maniac Mansion US (Beta) (NES) | 14:54 |
| 19. | Birdie_1991 Gaming. | 109 | Causing chaos driving around | 0:56 |
| 20. | Amigos Retro Gaming | 109 | Amigos Plays Maniac Mansion (Amiga) Full Playthrough | 2:20:47 |
| 21. | Rydo | 83 | 🌭The Cave #14 | 34:16 |
| 22. | SUBPARCADE | 82 | Just a couple of tuna heads beating Maniac Mansion | 1:08:12 |
| 23. | thomas blaszkiewicz | 61 | " WELCOME TO THOMAS RETRO GAMER Plays Maniac Mansion (nes classic) " | 3:56:02 |
| 24. | Ken Innes IV | 59 | Beating Maniac Mansion (NES) with Bernard & Wendy, My Playthrough (7/27/2023) | 1:21:42 |
| 25. | Funky G | 52 | Let's Play Maniac Mansion (BLIND) Part 5: FINALE | 1:01:05 |
| 26. | RetroGameQuest | 46 | Quest #61: Maniac Mansion [NES] (Complete playthrough with Bernard) | 1:14:16 |
| 27. | Video Game Attic | 33 | Maniac Mansion Playthrough (Wendy and Bernard) | 3:13:20 |
| 28. | Reliving Retro | 32 | I Can't Believe The Game Let's You Do THIS!! | Maniac Mansion Playthrough | 9:55 |
| 29. | Vauldemare | 31 | Let's Play Sam & Max Hit the Road Part-10 Faux Bigfoot (Finale 1/2) | 28:30 |
| 30. | Whitney Plays | 25 | Whitney Plays Maniac Mansion (PC) for Extra Life 2021 (PART 03) (END) | 2:27:01 |
| 31. | Ridiculoud | 22 | Let's Play Maniac Mansion - Technical Food - Part 2 - Ridiculoud | 10:18 |
| 32. | VGamingJunkie | 18 | 🎮 Let's Play 🎮 Maniac Mansion - The Hungry Tentacle? Get into That Mansion! | 32:15 |
| 33. | Starfang Plays! | 16 | Maniac Mansion Deluxe PT2 - Michael playthrough | 51:10 |
| 34. | Endara Gaming | 15 | Maniac Mansion (NES) | Let's Play! | 2:23:50 |
| 35. | Milquetoast Gaming | 15 | MANIAC MANSION Full-Playthrough | Halloween Special 2023 | 2:57:45 |
| 36. | jasonsgroovemachine | 8 | Let's Play Maniac Mansion | 57:34 |
| 37. | Uncle Swinney Games | 4 | Uncle Swinney Plays: Vampire The Masquerade: Bloodlines: Part 9: Maniac Mansion. | 1:04:44 |
