| 1. |  TheGamingBritShow | 327,649 | No More Heroes 2's Killer Soundtrack | 17:40 |
| 2. | rabbidluigi | 296,613 | 'Sucker Punch' - No More Heroes 2: Desperate Struggle [FINALE] | 21:58 |
| 3. | Nintendo Life | 152,890 | No More Heroes 1 & 2: Desperate Struggle Nintendo Switch Review - Are They Worth It? | 15:00 |
| 4. | LowHP | 28,216 | Kill Bill Vol 1, but its a No More Heroes 2 Ranking Match | 5:03 |
| 5. | UpstartDJ | 11,186 | Lets Play No More Heroes 2 Desperate Struggle! Part 33: End the Struggle! | 21:44 |
| 6. | Da Passion | 10,214 | No More Heroes 2: Desperate Struggle - All Wrestling Moves - Nintendo Switch | 4:44 |
| 7. | HellfireComms | 5,452 | Ain't no kill like overkill! [No More Heroes 2] [HFC Livestream highlight] | 1:17 |
| 8. | VideoGameJNPoop | 3,816 | Rating Vs. Rating - Episode 1: BBFC Vs. PEGI (Part 1) | 3:45 |
| 9. | Trash or Treasure? | 3,669 | No More Heroes 1 & 2 - Trash or Treasure? | Full of Moe | 26:30 |
| 10. | Source Gaming | 3,356 | No More Heroes 1+2 Review (SWITCH) | 21:21 |
| 11. | rabbid2igi | 3,044 | HIGHLIGHTS: Let's Play No More Heroes 2: Desperate Struggle | 10:11 |
| 12. | Hadski Gaming | 2,733 | The Final Boss - Jasper Batt Jr Boss Fight - No More Heroes 2: Desperate Struggle - Switch | 12:17 |
| 13. | forthenext | 2,365 | ANBERNIC RG556, Wii - No More Heroes 2 and 9 games test | 1:58:27 |
| 14. | AbsinthTears Gaming | 1,781 | No More Heroes 2: Desperate Struggle - Launch Trailer - Nintendo Switch | 1:40 |
| 15. | SefiroCrescent | 1,622 | Playing No More Heroes 2 - Switch (Part 1) | 2:45:18 |
| 16. | Hummsvillian | 1,246 | Travis Touchdown 3d | 0:20 |
| 17. | Sir Cracker Bulb | 1,155 | [OLD] No More Heroes 2 Review | 17:23 |
| 18. | ShopTo | 902 | No More Heroes 2: Desperate Struggle Introduction Trailer | 2:03 |
| 19. | Megaspartan23 | 881 | No More Heros 2 - PC Longplay 1440p 60FPS No Commentary | 6:39:25 |
| 20. | JohnTMorton | 734 | Nostalgamer 4K Unboxing No More Heroes 2 Desperate Struggle Collectors Edition On Nintendo SwitchLRG | 12:55 |
| 21. | URBAN GAMEPLAY | 709 | No More Heroes and No More Heroes 2: Desperate Struggle Switch limited Collectors edition | 2:40 |
| 22. | mariotaz | 493 | No More Heroes 2: Rank Defense Match 1 | 7:56 |
| 23. | Jobi-Wan-Kanobi | 455 | No More Heroes 2: Desperate Struggle - #6 - Funko-Pop-phobia Returns | 10:19 |
| 24. | Tome | 452 | NO MORE HEROES 2 REMAKE PLOT LEAK! PIKACHU DOES IT AGAIN | 0:31 |
| 25. | InfinitelyBored | 440 | No More Heroes 2: Hoppers Edition - Unboxing and Review | 13:05 |
| 26. | Fry | 420 | DBZ BT3 Mission 47 - The Professor's Masterpiece | 4:57 |
| 27. | Limulouse | 359 | You like the way I rub that pussy, huh? 😏😏😏 | 0:30 |
| 28. | Feel The Niche | 292 | SUDA 51 MONTH | No More Heroes 2 FINAL: DOWNWARD F****** DOG! | 4:52:24 |
| 29. | DefenderofHyrule | 280 | 1 vs 2: No More Heroes vs No More Heroes: Desperate Struggle | 29:00 |
| 30. | dee fault | 228 | How to make SHINOBU from NO MORE HEROES 2 in Soul Calibur VI | 5:27 |
| 31. | gamezplay | 190 | No More Heroes & No More Heroes 2 Desperate Struggle cult classics come to PC | 3:42 |
| 32. | Is It Playable? | 185 | Is No More Heroes 2: Desperate Struggle Playable? RetroArch Performance [Series X | Dolphin] | 11:06 |
| 33. | Dan's Distillery | 146 | NO MORE HEROES 2: DESPERATE STRUGGLE [NINTENDO SWITCH] - IT'S GAME TIME!!! [GAMEPLAY] | 1:16:53 |
| 34. | Johnboydojo | 126 | Awesome Package from Australia!! A Chance to Cosplay? | 0:00 |
| 35. | Portable Roundup | 126 | Rising Star Games 10th Anniversary video | 1:08 |
| 36. | Guias Nyx | 88 | No More Heroes 2: Desperate Struggle Finale: Hate and Anguish | 1:34:30 |
| 37. | Classic Retro Game Room | 86 | Lets Play No More Heroes 2 For The Nintendo Wii Classic Retro Game Room | 14:26 |
| 38. | Jev Da Ninja Plays | 64 | No More Heroes 2: Desperate Struggle - (Part 3) [Mild Difficulty] [FINAL] | 2:10:05 |
| 39. | MaelstromALPHA | 50 | «MaelstromALPHA» No More Heroes 2: Desperate Struggle (Part 3 - Finale) | 2:37:09 |
| 40. | Xupgeeks | 39 | No More Heroes 2 Desperate Struggle Gameplay on the Nintendo Switch | 54:13 |
| 41. | A Hero In Hell | 37 | No More Heroes 2: Desperate Struggle - Intro (Nintendo Wii) | 1:48 |
| 42. | afrobears & WhiteKitsu | 34 | afrobears & WhiteKitsu || No More Heroes 2 Desperate Struggle (Final) [Switch] | 2:41:36 |
| 43. | PaddyKret | 28 | Travis' Trauma Dejavu | 3:39:09 |
| 44. | Scott E | 28 | No More Heroes 2: Desperate Struggle - 45 Minutes of Gameplay (Nintendo Switch) | 46:17 |
| 45. | Miirio Vods & More | 22 | No More Heros 2 #1 | 5:38:41 |
| 46. | NCN || Channel 111 | 21 | NCN || NO MORE HEROES 2: DESPERATE STRUGGLE || | 0:00 |
| 47. | Gnator8t4 | 20 | No More Heroes 2: Desperate Struggle Review | 11:45 |
| 48. | MakiIzMe | 19 | SQAUTTING FOR HOMIES? | 30:14 |
| 49. | Nudoc PRIME | 16 | Rate the skin No More heros 2 Margaret Moonlight | 4:16 |
| 50. | Myr the Moth | 15 | No More Heroes 2 - Part 3 Finale | 3:36:09 |
| 51. | Kori Stream Archive | 13 | Kori: No More Heroes 2 [VOD · 01] | 3:46:09 |
| 52. | GHOSTVTS | 13 | GHOST VS NO MORE HEROES 2: DESPERATE STRUGGLE | DAY 2 | 0:00 |
| 53. | Streamcast | 12 | No More Heroes 2 Review | 5:36 |
| 54. | Never Game Nova | 10 | NO MORE HEROES 2: DESPERATE STRUGGLE - SWITCH Walkthrough - PART 14 - JASPER BATT JR | 55:33 |
| 55. | DisTurBed2236 | 9 | No More Heroes 2: Desperate Struggle - Full Playthrough - Part Four (Finale) | 1:34:12 |
| 56. | yoezzy12 | 7 | NMH2 vs Matt helms | 0:30 |
| 57. | Yazura Streams | 7 | No More Heroes 2 | 8:39:13 |
| 58. | LordMegaWin Gaming | 6 | No More Heroes 2 Desperate struggle 2 of 2 Nintendo Wii | 4:43:15 |
| 59. | Ninqueso Plays | 6 | Queso Plays No More Heroes 2 - Part 1 | 48:20 |
| 60. | Foxtrot industries | 2 | No More Heroes 2 Highlights! | 21:45 |
| 61. | The Glamorous Gaming Misfit | 2 | No More Heroes 2: Desperate Struggle (Wii) - PART 5 - Let's Sample - GGMisfit | 17:37 |
| 62. | Rasendan Stream Archive | 0 | 🏴☠️Back with the GRIND with ya boi TRAVIS🏴☠️ NMH2 FINALE | 4:39:11 |
