| 1. |  Aliensrock | Programming Extremely Satisfying Alchemy Machines! - Opus Magnum | 10,370 | |
| 2. |  OfficialNerdCubed | Nerd³ Recommends Opus Magnum - Alchemy Machines | 5,525 | |
| 3. | OfficialNerdCubed | The Nerd³ Show - 06/07/19 - I am an Idiot | 3,676 | |
| 4. | Aliensrock | Optimizing My Factory for Speed AND Size! - Opus Magnum | 2,907 | |
| 5. | Northernlion | Let's Look At: Opus Magnum! | 2,319 | |
| 6. | Matthewmatosis | Opus Magnum Review | 2,225 | Review |
| 7. | IGN | Best Reviewed Games of 2017 | 1,859 | Review |
| 8. | quill18 | Let's Try: Opus Magnum -- Design and Build Alchemical Machines | 1,798 | |
| 9. | Aliensrock | How to Play Opus Magnum: A Tutorial For Dummies | 1,727 | Tutorial |
| 10. |  ZeratoR | Opus Magnum #1 : Découverte | 1,727 | |
| 11. | IGN | Opus Magnum Review | 1,685 | Review |
| 12. |  Sterakdary | Opus Magnum - Přeměníme Olovo na Zlato? [CZ / Česky] | 1,505 | |
| 13. | Scott Manley | Opus Magnum - Alchemy Meets NanoAssembly | 1,363 | |
| 14. | Zachtronics | Opus Magnum, by Zachtronics | 1,368 | |
| 15. | Super Beard Bros | Opus Magnum Makes Us Alchemists | Eff It Beard Bros | 1,238 | |
| 16. | ZeratoR | Opus Magnum #2 : IL EST VIVANT | 958 | |
| 17. | ZeratoR | Opus Magnum : Présentation en 1min31 | 948 | |
| 18. | Jelly Ch. 【Phase Connect】 | Selling Phase Connect Coffee!! 🌠 | 906 | |
| 19. | EnterElysium | OPUS MAGNUM Amazing Alchemist Game - Let's Look / Gameplay | 848 | Let's Play |
| 20. | Many A True Nerd | Opus Magnum - Turning Lead into Tin Doesn't Sound As Impressive | 831 | |
| 21. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 1 - Mindbender | 769 | Let's Play |
| 22. | EnterElysium | OPUS MAGNUM | HANGOVER CURE #01 Amazing Alchemist Game - Let's Play / Gameplay | 706 | Let's Play |
| 23. |  arhn2eu - arhn.eu po godzinach | Opus Magnum -- Podgląd #120 | 682 | |
| 24. | bigmacdontcare | Opus Magnum Cycle Optimization Tutorial | 657 | Tutorial |
| 25. | OfficialNerdCubedLive | Nerd³'s Late Late Show - Opus Magnum - 17 Dec 2017 | 573 | |
| 26. | Jelly Ch. 【Phase Connect】 | 【OPUS MAGNUM】alchemy for dummies 🌠 | 541 | |
| 27. | KatherineOfSky | Opus Magnum Ep 1: IMPERIAL UNIVERSITY - Programming/Logic - First Look - Let's Play (Early Access) | 533 | Let's Play |
| 28. | Staszek iGRAszkowski | Opus Magnum PL #1 | Nowe arcydzieło Zachtronics! | 514 | |
| 29. | Haiaiai | Opus Magnum Computer (bf interpreter) | 494 | |
| 30. | Dan Field | OPUS MAGNUM [FR] LA référence des jeux de logique/programmations ! | 481 | Vlog |
| 31. | Jelly Ch. 【Phase Connect】 | puzzling together and catching up! 🌠 | 441 | |
| 32. | gtw123 | Opus Magnum - Automated Puzzle Solver | 404 | |
| 33. |  ZigTheHedge | 📽 [Запись стрима] - Opus Magnum - Алгоритмическая Алхимия. | 381 | |
| 34. | OfficialNerdCubedLive | Nerd³ Has Had A Long Day - Opus Magnum - 22 Jun 2018 | 361 | |
| 35. | EnterElysium | OPUS MAGNUM | MACHINE OIL #02 Amazing Alchemist Game - Let's Play / Gameplay | 347 | Let's Play |
| 36. | Giant Bomb | Opus Magnum: Quick Look | 315 | |
| 37. | Lytebringr | Airship Fuel (40/19/10) | Opus Magnum #7 Let's Play with Lyte | 315 | |
| 38. |  Idiotech | You Should Play - Opus Magnum | 309 | Review |
| 39. | EnterElysium | OPUS MAGNUM | STAMINA POTION #03 Amazing Alchemist Game - Let's Play / Gameplay | 301 | Let's Play |
| 40. | OfficialNerdCubedLive | Nerd³ Puzzles In A Box - Opus Magnum - 4 Jul 2018 | 283 | |
| 41. |  Koinsky | [FR] OPUS MAGNUM gameplay - ép 1 - Chaine de production alchimique ! | 261 | |
| 42. | Z | Opus Magnum OST - The Alchemist | 281 | |
| 43. |  PeiT | OPUS MAGNUM ► PeiT juega... [ gameplay español ] | 240 | |
| 44. | Staszek iGRAszkowski | Opus Magnum PL #2 | Kac, paliwo i olej | 215 | |
| 45. |  GodJJ | 【GodJJ】天才鍊金術師 GodJJ | 實況精華 (by Auto) | 195 | |
| 46. | supergreatfriend | Channel Update for December | 193 | |
| 47. | Staszek iGRAszkowski | Opus Magnum PL #5 | Ten tytuł dąży do nieskończoności, a przy okazji sprawdzę, jaki jest limit znakó | 187 | |
| 48. | Unofficial Nerdcubed Live! - Livestream Archive | Nerd³ Transmutates - Opus Magnum - 11th November 2017 - Featuring Rebecca | 190 | |
| 49. | Z | Opus Magnum OST - Transmutation Engine | 200 | |
| 50. | At0miumVOD | OPUS MAGNUM : Découverte de qualité | GAMEPLAY FR | 181 | |
| 51. | bigmacdontcare | Opus Magnum - the worst machine I could fit on one screen | 201 | |
| 52. | 彼君不触 | Some More Opus Magnum optimized solution | 172 | |
| 53. | bigmacdontcare | Opus Magnum Tournament 2020: Week 1 | 162 | |
| 54. | Staszek iGRAszkowski | Opus Magnum PL #3 | Eliksiry nawet na włosy | 156 | |
| 55. | 和泉 | 【Opus Magnum】構築ゲーミング | 165 | |
| 56. | Масон Артём | Opus Magnum. Алхимическая головоломка | 147 | |
| 57. | Keith Ballard | Let's Try Opus Magnum - Efficiency is for Cowards | 136 | |
| 58. | bigmacdontcare | Opus Magnum cycles tutorial - Multiple Pipelines | 133 | Tutorial |
| 59. | Accidental Games | Opus Magnum AND Logic Gate | 132 | Vlog |
| 60. | xisumatwo | Opus Magnum Livestream 28/01/22 | 131 | |
| 61. | Staszek iGRAszkowski | Opus Magnum PL #4 | Potrójne wiązania | 124 | |
| 62. |  Overloadr | Opus Magnum Gameplay - Shuffle | 118 | |
| 63. |  M4ya qq | #1【パズル】Opus Magnum - まーやの実験室へようこそ | 112 | |
| 64. | Z | Opus Magnum OST - Traditions | 118 | |
| 65. | Z | Opus Magnum OST - Intrigue | 121 | |
| 66. | Haiaiai | Opus Magnum Computer, zoomed out demo | 112 | |
| 67. | Lytebringr | Refined Gold (40/62/6) | Opus Magnum #3 Let's Play with Lyte | 111 | |
| 68. | Z | Opus Magnum OST - Opulence | 114 | |
| 69. | Unofficial Nerdcubed Live! - Livestream Archive | Nerd³ Sleepily Transmutates - Opus Magnum - 13th November 2017 - Featuring Rebecca | 104 | |
| 70. | Koinsky | [FR] OPUS MAGNUM Découverte Carburant + Solution optimisée Or raffiné | 102 | |
| 71. | Lytebringr | Hair Product (30/50/8) | Opus Magnum #11 Let's Play with Lyte | 101 | |
| 72. | Lytebringr | Armor Filament (50/49/32) | Opus Magnum #16 Let's Play with Lyte | 100 | |
| 73. | Lytebringr | Precision Machine Oil (60/28/11) | Opus Magnum #8 Let's Play with Lyte | 99 | |
| 74. | Lytebringr | Litharge Separation (30/24/13) | Opus Magnum #27 Let's Play with Lyte | 99 | |
| 75. | bigmacdontcare | Opus Magnum Tournament 2020: Week 7 | 98 | |
| 76. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 7 - The Fall Of House Van Tassen | 97 | Let's Play |
| 77. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 6 - One Armed Wonder | 96 | Let's Play |
| 78. | Stuff+ | Opus Magnum - Purification Programming Puzzle - Let's Play / Gameplay / Beverage | 92 | Let's Play |
| 79. | Lytebringr | Surrender Flare (70/19/27) | Opus Magnum #19 Let's Play with Lyte | 90 | |
| 80. | Dexbonus | OCTOBER 26, 2017 Part 1: Neurovoider, Opus Magnum | 89 | |
| 81. | Z | Opus Magnum OST - Sigmar's Garden | 87 | |
| 82. | Lytebringr | Tutorial Puzzle | Opus Magnum #1 Let's Play with Lyte | 83 | |
| 83. | Neno Taylor | Rule 110 automata in Opus Magnum | 83 | |
| 84. | Lytebringr | Stamina Potion (70/32/23) | Opus Magnum #10 Let's Play with Lyte | 81 | |
| 85. | Lytebringr | Sigmar's Garden Basic Strategies | Opus Magnum #1 Let's Play with Lyte | 79 | |
| 86. | Z | Opus Magnum OST - Beauty | 83 | |
| 87. | Lytebringr | Waterproof Sealant (30/26/8) | Opus Magnum #5 Let's Play with Lyte | 77 | |
| 88. | Lytebringr | Face Powder (40/26/7) | Opus Magnum #4 Let's Play with Lyte | 76 | |
| 89. | Z | Opus Magnum OST - Introduction | 85 | |
| 90. | Lazy Leo | А давайте сыграем Opus Magnum | 75 | |
| 91. | Lytebringr | Hangover Cure (40/39/8) | Opus Magnum #6 Let's Play with Lyte | 71 | |
| 92. | Lytebringr | Rocket Propellant (40/33/11) | Opus Magnum #13 Let's Play with Lyte | 70 | |
| 93. | Rakupenda | Tips and Tricks for Finding Lowest Cost Solutions - Opus Magnum | 70 | |
| 94. | bigmacdontcare | This Opus Magnum machine scores higher than Graham’s number | 69 | |
| 95. | Dexbonus | OCTOBER 30, 2017: Opus Magnum | 68 | |
| 96. | INDIE | Opus Magnum №1 - Лучшая головоломка | 68 | |
| 97. |  th_pion | Opus Magnum - Pion's Primal Perception | 67 | |
| 98. | Lytebringr | Health Tonic (30/26/15) | Opus Magnum #9 Let's Play with Lyte | 64 | |
| 99. | bigmacdontcare | Opus Magnum Tournament 2020: Week 2 | 64 | |
| 100. | Opus Magnum | DEDNET / Казино Diamond #2 / Нож в мэрии | 63 | |
