| 1. |  Aliensrock | Programming Extremely Satisfying Alchemy Machines! - Opus Magnum | 567 | |
| 2. | IGN | Best Reviewed Games of 2017 | 502 | Review |
| 3. |  OfficialNerdCubed | Nerd³ Recommends Opus Magnum - Alchemy Machines | 496 | |
| 4. | OfficialNerdCubed | The Nerd³ Show - 06/07/19 - I am an Idiot | 304 | |
| 5. | Matthewmatosis | Opus Magnum Review | 238 | Review |
| 6. | Northernlion | Let's Look At: Opus Magnum! | 235 | |
| 7. | Aliensrock | If Hook Was So Good, Why Isn't There a Hook 2? Oh Wait... | 212 | |
| 8. | Super Beard Bros | Opus Magnum Makes Us Alchemists | Eff It Beard Bros | 166 | |
| 9. | Aliensrock | Optimizing My Factory for Speed AND Size! - Opus Magnum | 151 | |
| 10. | Many A True Nerd | Opus Magnum - Turning Lead into Tin Doesn't Sound As Impressive | 129 | |
| 11. | EnterElysium | OPUS MAGNUM | HANGOVER CURE #01 Amazing Alchemist Game - Let's Play / Gameplay | 128 | Let's Play |
| 12. | quill18 | Let's Try: Opus Magnum -- Design and Build Alchemical Machines | 119 | |
| 13. | EnterElysium | OPUS MAGNUM Amazing Alchemist Game - Let's Look / Gameplay | 109 | Let's Play |
| 14. | Scott Manley | Opus Magnum - Alchemy Meets NanoAssembly | 98 | |
| 15. | IGN | Opus Magnum Review | 90 | Review |
| 16. | Aliensrock | How to Play Opus Magnum: A Tutorial For Dummies | 82 | Tutorial |
| 17. | KatherineOfSky | Opus Magnum Ep 1: IMPERIAL UNIVERSITY - Programming/Logic - First Look - Let's Play (Early Access) | 81 | Let's Play |
| 18. |  Sterakdary | Opus Magnum - Přeměníme Olovo na Zlato? [CZ / Česky] | 77 | |
| 19. |  ZeratoR | Opus Magnum #1 : Découverte | 75 | |
| 20. | supergreatfriend | Channel Update for December | 58 | |
| 21. | Haiaiai | Opus Magnum Computer (bf interpreter) | 53 | |
| 22. | gtw123 | Opus Magnum - Automated Puzzle Solver | 51 | |
| 23. | OfficialNerdCubedLive | Nerd³ Has Had A Long Day - Opus Magnum - 22 Jun 2018 | 49 | |
| 24. |  Staszek iGRAszkowski | Opus Magnum PL #1 | Nowe arcydzieło Zachtronics! | 47 | |
| 25. | Giant Bomb | Opus Magnum: Quick Look | 43 | |
| 26. |  ZigTheHedge | 📽 [Запись стрима] - Opus Magnum - Алгоритмическая Алхимия. | 41 | |
| 27. | EnterElysium | OPUS MAGNUM | MACHINE OIL #02 Amazing Alchemist Game - Let's Play / Gameplay | 39 | Let's Play |
| 28. | bigmacdontcare | Opus Magnum Cycle Optimization Tutorial | 39 | Tutorial |
| 29. | Lytebringr | Stamina Potion (70/32/23) | Opus Magnum #10 Let's Play with Lyte | 38 | |
| 30. | OfficialNerdCubedLive | Nerd³'s Late Late Show - Opus Magnum - 17 Dec 2017 | 38 | |
| 31. | ZeratoR | Opus Magnum #2 : IL EST VIVANT | 38 | |
| 32. |  GodJJ | 【GodJJ】天才鍊金術師 GodJJ | 實況精華 (by Auto) | 38 | |
| 33. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 1 - Mindbender | 35 | Let's Play |
| 34. | Unofficial Nerdcubed Live! - Livestream Archive | Nerd³ Transmutates - Opus Magnum - 11th November 2017 - Featuring Rebecca | 34 | |
| 35. | Lazy Leo | А давайте сыграем Opus Magnum | 32 | |
| 36. | Keith Ballard | Let's Try Opus Magnum - Efficiency is for Cowards | 30 | |
| 37. | Lytebringr | Hangover Cure (40/39/8) | Opus Magnum #6 Let's Play with Lyte | 30 | |
| 38. | Dan Field | OPUS MAGNUM [FR] LA référence des jeux de logique/programmations ! | 30 | Vlog |
| 39. | Accidental Games | Opus Magnum AND Logic Gate | 29 | Vlog |
| 40. | EnterElysium | OPUS MAGNUM | STAMINA POTION #03 Amazing Alchemist Game - Let's Play / Gameplay | 28 | Let's Play |
| 41. |  Idiotech | You Should Play - Opus Magnum | 28 | Review |
| 42. |  Koinsky | [FR] OPUS MAGNUM gameplay - ép 1 - Chaine de production alchimique ! | 28 | |
| 43. | Lytebringr | Combined Metric | Opus Magnum #2 Let's Play with Lyte | 27 | |
| 44. | Staszek iGRAszkowski | Opus Magnum PL #3 | Eliksiry nawet na włosy | 25 | |
| 45. | Staszek iGRAszkowski | Opus Magnum PL #5 | Ten tytuł dąży do nieskończoności, a przy okazji sprawdzę, jaki jest limit znakó | 25 | |
| 46. | Lytebringr | Litharge Separation (30/24/13) | Opus Magnum #27 Let's Play with Lyte | 24 | |
| 47. | Lytebringr | Airship Fuel (40/19/10) | Opus Magnum #7 Let's Play with Lyte | 24 | |
| 48. | Lytebringr | Life-Sensing Potion (80/31/18) | Opus Magnum #25 Let's Play with Lyte | 24 | |
| 49. | Staszek iGRAszkowski | Opus Magnum PL #2 | Kac, paliwo i olej | 23 | |
| 50. | Lytebringr | Surrender Flare (70/19/27) | Opus Magnum #19 Let's Play with Lyte | 23 | |
| 51. | OfficialNerdCubedLive | Nerd³ Puzzles In A Box - Opus Magnum - 4 Jul 2018 | 22 | |
| 52. | arhn2eu - arhn.eu po godzinach | Opus Magnum -- Podgląd #120 | 21 | |
| 53. | Etrigane | [PC] Opus Magnum - Quand Zachtronics se met à l'alchimie ♥ | 21 | |
| 54. | Lytebringr | Hair Product (30/50/8) | Opus Magnum #11 Let's Play with Lyte | 21 | |
| 55. | Lytebringr | Health Tonic (30/26/15) | Opus Magnum #9 Let's Play with Lyte | 21 | |
| 56. | Lytebringr | Unstable Compound (60/63/23) | Opus Magnum #37 Let's Play with Lyte | 21 | |
| 57. | Jelly Ch. 【Phase Connect】 | 【OPUS MAGNUM】alchemy for dummies 🌠 | 20 | |
| 58. | Lytebringr | Precision Machine Oil (60/28/11) | Opus Magnum #8 Let's Play with Lyte | 20 | |
| 59. | Jelly Ch. 【Phase Connect】 | Selling Phase Connect Coffee!! 🌠 | 20 | |
| 60. | bigmacdontcare | Opus Magnum - the worst machine I could fit on one screen | 18 | |
| 61. | Alex Diener | Opus Magnum - E1: Pretension | 18 | |
| 62. | Lytebringr | Armor Filament (50/49/32) | Opus Magnum #16 Let's Play with Lyte | 18 | |
| 63. | Benjamin Magnus Games | Opus Magnum | Zachtronics | House Van Tassen | Refined Gold | 18 | |
| 64. | Lytebringr | Refined Gold (40/62/6) | Opus Magnum #3 Let's Play with Lyte | 17 | |
| 65. |  PeiT | OPUS MAGNUM ► PeiT juega... [ gameplay español ] | 17 | |
| 66. | Koinsky | [FR] OPUS MAGNUM Découverte Carburant + Solution optimisée Or raffiné | 17 | |
| 67. | ZeratoR | Opus Magnum : Présentation en 1min31 | 16 | |
| 68. | Jelly Ch. 【Phase Connect】 | puzzling together and catching up! 🌠 | 16 | |
| 69. | Lytebringr | Water Purifier (50/47/15) | Opus Magnum #21 Let's Play with Lyte | 16 | |
| 70. | Lytebringr | Stain Remover (80/53/25) | Opus Magnum #28 Let's Play with Lyte | 16 | |
| 71. | Lytebringr | Mist of Incapacitation (60/26/12) | Opus Magnum #14 Let's Play with Lyte | 15 | |
| 72. | Lytebringr | Purified Gold (55/112/9) | Opus Magnum #31 Let's Play with Lyte | 15 | |
| 73. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 6 - One Armed Wonder | 15 | Let's Play |
| 74. |  th_pion | Opus Magnum - Pion's Primal Perception | 15 | |
| 75. | Lytebringr | Very Dark Thread (75/51/53) | Opus Magnum #26 Let's Play with Lyte | 14 | |
| 76. | Lytebringr | Face Powder (40/26/7) | Opus Magnum #4 Let's Play with Lyte | 14 | |
| 77. | Lytebringr | Rocket Propellant (40/33/11) | Opus Magnum #13 Let's Play with Lyte | 14 | |
| 78. | Z | Opus Magnum OST - The Alchemist | 14 | |
| 79. | At0miumVOD | OPUS MAGNUM : Découverte de qualité | GAMEPLAY FR | 14 | |
| 80. | bigmacdontcare | This Opus Magnum machine scores higher than Graham’s number | 13 | |
| 81. | Lytebringr | Tutorial Puzzle | Opus Magnum #1 Let's Play with Lyte | 13 | |
| 82. | Haiaiai | Opus Magnum Computer, zoomed out demo | 13 | |
| 83. | Lytebringr | Climbing Rope Fiber (40/74/45) | Opus Magnum #23 Let's Play with Lyte | 13 | |
| 84. | Lytebringr | Timing Crystal (40/219/36) | Opus Magnum #35 Let's Play with Lyte | 13 | |
| 85. | Alex Diener | Opus Magnum - E4: Marbles | 13 | |
| 86. | Lytebringr | Waterproof Sealant (30/26/8) | Opus Magnum #5 Let's Play with Lyte | 12 | |
| 87. | bigmacdontcare | Opus Magnum - Curious Lipstick (memorized solution) in 1:59 | 12 | |
| 88. | 1vader | Automated Sigmar's Garden Solver (Opus Magnum Minigame) | 12 | |
| 89. | nie|poradnik | Opus Magnum - zagrajmy! | 12 | |
| 90. |  Overloadr | Opus Magnum Gameplay - Shuffle | 12 | |
| 91. |  거터 | 최저가 공장만드는 게임 (Opus Magnum) | 12 | |
| 92. | Lytebringr | Warming Tonic (40/27/17) | Opus Magnum #24 Let's Play with Lyte | 11 | |
| 93. | Unofficial Nerdcubed Live! - Livestream Archive | Nerd³ Sleepily Transmutates - Opus Magnum - 13th November 2017 - Featuring Rebecca | 11 | |
| 94. | Czwórka | Warto zagrać w Opus Magnum! | 11 | |
| 95. | Rakupenda | Surrender Flare | (60G) LOWEST COST | Opus Magnum Chapter 02 | 11 | |
| 96. | Neno Taylor | Rule 110 automata in Opus Magnum | 11 | |
| 97. | INDIE | Opus Magnum №1 - Лучшая головоломка | 11 | |
| 98. | bigmacdontcare | Opus Magnum - Very Dark Thread in 50 cycles | 11 | |
| 99. | Opus Magnum | DEDNET / Казино Diamond #2 / Нож в мэрии | 10 | |
| 100. | Z | Opus Magnum OST - Transmutation Engine | 10 | |
