| 301. |  vizthex | 1 | I finally 100% Opus Magnum!! | 1:30 |
| 302. | GSTG | 1 | Opus Magnum [GAMEPLAY] - PC | 23:11 |
| 303. |  소년시노비 | 1 | 연금술로 금을 만들어 봅시다. (Opus Magnum) Live 2020.05.03 | 1:51:13 |
| 304. |  W_L_V stream | 1 | Игровое оливье (стрим по "......") | 10:43:41 |
| 305. |  AKheon | 1 | Opus Magnum - speedrun to fastest crash | 0:17 |
| 306. | 거터 | 1 | 최저가 공장만드는 게임 (Opus Magnum) | 5:24 |
| 307. | Marstead | 1 | ▶️ Start Playthrough - Opus Magnum [Blind] (Episode 1) | 1:02:48 |
| 308. | astray3k | 1 | Opus Magnum Gameplay | 12:02 |
| 309. | OneHourGames | 1 | Opus Magnum [1080p60] | One Hour | 1:02:43 |
| 310. | Czwórka | 1 | Warto zagrać w Opus Magnum! | 20:38 |
| 311. |  Accidental Games | 1 | Opus Magnum AND Logic Gate | 1:12 |
| 312. |  At0miumVOD | 1 | OPUS MAGNUM : Découverte de qualité | GAMEPLAY FR | 2:47:04 |
| 313. |  iridian | 1 | Opus magnum - solutions first three chapters | 16:11 |
| 314. |  GodJJ | 1 | 【GodJJ】天才鍊金術師 GodJJ | 實況精華 (by Auto) | 11:43 |
| 315. | Xopo | 1 | КЛОН Opus Magnum Velone ВЕЛИКИЕ ЗНАНИЯ УМИРАЮЩЕЙ ЦИВИЛИЗАЦИИ | 17:23 |
| 316. | lord batair | 1 | Opus Magnum [FR] : quand les bidules machinent les trucs | 1:09:14 |
| 317. | Matthewmatosis | 1 | Opus Magnum Review | 19:08 |
| 318. | Aylad Plays / Gaming and Ambience | 1 | Indie Speed Dating: Opus Magnum #opusmagnum | 26:44 |
| 319. | Nemesis6001 | 1 | How To Make New Elements - Opus Magnum #1 | 34:52 |
| 320. | JV lemag | 1 | JV 13/14 - Opus Magnum | 56:40 |
| 321. | Etrigane | 1 | [PC] Opus Magnum - Quand Zachtronics se met à l'alchimie ♥ | 1:02:16 |
| 322. | Масон Артём | 1 | Opus Magnum. Алхимическая головоломка | 3:00:42 |
| 323. |  IndieGoTV | 1 | Opus Magnum Vandorral [HUN/Magyar] | 40:23 |
| 324. | Yello Rambo | 1 | Opus Magnum | Alkimista szimulátor | 53:09 |
| 325. | Kutena Smegenis | 1 | Kutena Smegenis: Sausi Pusryčiai: Opus Magnum | 1:23:19 |
| 326. | Capsule Computers | 1 | Opus Magnum | Play Me Maybe | 1:11:27 |
| 327. |  UltimateBIM | 1 | Opus Magnum ⚗️ 01: Die Welt der Alchemie ist komplex! | 3:17:35 |
| 328. |  Overloadr | 1 | Opus Magnum Gameplay - Shuffle | 24:39 |
| 329. | Foxmaiden | 1 | #1 A automatização de elementos! - PT-BR/EN - Opus Magnum | 1:40:19 |
| 330. |  Brand Gaming | 1 | Opus Magnum Gameplay [HD] [PC] | 10:01 |
| 331. | HellfireComms | 1 | NTom and Volk's Spot of PC [#42: Opus Magnum] | 26:01 |
| 332. |  JamieWCE | 1 | Opus Magnum - Episode Zero | 16:43 |
| 333. | Biohazard063 LP | 1 | Opus Magnum |Gameplay| Ep2. Gravitas | 27:56 |
| 334. | Game Developer | 1 | Gamasutra plays Opus Magnum with Zach Barth and Matthew Burns | 1:02:31 |
| 335. | News Cartridge | 1 | GOG Accepts Opus Magnum | 4:29 |
| 336. | Straw Man Gaming | 1 | Let's Look at: Opus Magnum | 41:14 |
| 337. | TroZ | 1 | Opus Magnum Look | 34:31 |
| 338. | Kazzoi | 1 | Alchemical Programming | 30 Minutes of.. Opus Magnum | 48:42 |
| 339. |  Game Club & Pub | 1 | Подкаст Overtime, выпуск №113 [Intel обделалась, Nintendo на коне, оскорбленные индейцы] | 1:35:35 |
| 340. | Super Beard Bros | 1 | Opus Magnum Makes Us Alchemists | Eff It Beard Bros | 20:45 |
| 341. | Tench Froast | 1 | Opus Magnum on Xbox Game Pass | First 15 | 22:47 |
| 342. | Nemellia | 1 | Il était un jeu ... Opus Magnum [FR] | 35:06 |
| 343. | ZitterFrost | 1 | Opus Magnum | mal sehn | Gameplay German Deutsch | 23:00 |
| 344. | セシカ-Sesika | 1 | #1【オーパスマグナム】錬金術とパズルの融合 チュートリアル編【Opus Magnum】 | 26:30 |
| 345. | Ashker Nms | 1 | [FR] [PC] Opus Magnum : Casse-tête Alchimique | 2:31:14 |
| 346. | Jordan Chokad | 1 | Opus Magnum Gameplay part 1 | 16:41 |
| 347. |  PeiT | 1 | OPUS MAGNUM ► PeiT juega... [ gameplay español ] | 48:58 |
| 348. | xisumatwo | 1 | Opus Magnum Livestream 28/01/22 | 3:38:04 |
| 349. |  Sterakdary | 1 | Opus Magnum - Přeměníme Olovo na Zlato? [CZ / Česky] | 21:41 |
| 350. |  Tagashy-たがし- | 1 | #1【謎解きパズル】Opus Magnum【生放送】 | 2:16:25 |
| 351. | SB | 1 | What's Good In 2017? Puzzle Games! | 4:51 |
| 352. | supergreatfriend | 1 | Channel Update for December | 13:14 |
| 353. | Scott Manley | 1 | Opus Magnum - Alchemy Meets NanoAssembly | 16:26 |
| 354. | DDRJake | 1 | Weekly One Shot #074: Opus Magnum [RE-UPLOAD] | 8:13:25 |
| 355. | NoxNeo LP | 1 | Alchemy Classic - Opus Magnum - #04 | 18:05 |
| 356. | Giant Bomb | 1 | Opus Magnum: Quick Look | 1:09:47 |
| 357. | Benjamin Magnus Games | 1 | Opus Magnum | Zachtronics | House Van Tassen | Refined Gold | 34:15 |
| 358. | KatherineOfSky | 1 | Opus Magnum Ep 1: IMPERIAL UNIVERSITY - Programming/Logic - First Look - Let's Play (Early Access) | 25:14 |
| 359. |  arhn2eu - arhn.eu po godzinach | 1 | Opus Magnum -- Podgląd #120 | 3:43 |
| 360. | Many A True Nerd | 1 | Opus Magnum - Turning Lead into Tin Doesn't Sound As Impressive | 30:47 |
| 361. | Idiotech | 1 | You Should Play - Opus Magnum | 15:51 |
| 362. | Dan Field | 1 | OPUS MAGNUM [FR] LA référence des jeux de logique/programmations ! | 33:59 |
| 363. | Dad's Gaming Addiction | 1 | DGA Plays: Opus Magnum (Ep. 1 - Gameplay / Let's Play) | 23:01 |
| 364. |  MaxDifficultyGaming | 1 | Hook - Puzzle Game - Walkthrough | 4:10 |
| 365. | AyorSaeba | 1 | [Rediff][LivePlay] Opus Magnum (PC) | 20:55 |
| 366. | Hadriex | 1 | Opus Magnum - First impressions | 2:41:37 |
| 367. | Northernlion | 1 | Let's Look At: Opus Magnum! | 49:25 |
| 368. | Keith Ballard | 1 | Let's Try Opus Magnum - Efficiency is for Cowards | 1:13:43 |
| 369. | quill18 | 1 | Let's Try: Opus Magnum -- Design and Build Alchemical Machines | 32:36 |
