| 1. |  MartinSpielt | 5,937 | Serena - Let's Play - Teil 2/2 | 48:54 |
| 2. |  Keith Ballard | 2,336 | Let's Play Serena - Do I Deserve to Be Forgiven? | 59:28 |
| 3. | Shook50 | 1,622 | Let's Play Serena (Suspensful, Spooky Point and Click Adventure) | 39:10 |
| 4. |  YagmanX | 1,528 | Wimpy Girl Plays Serena | That Ending?! | 23:38 |
| 5. | God is a Geek | 726 | Serena - Let's Play | 10:23 |
| 6. |  Cam | 521 | Cam Plays: Prom Dreams | Part 8 | The Forger's Hand Ending | 55:19 |
| 7. | The RPG Chick | 389 | Let's Play Asylum (Demo - Blind), Part 1 of 4: Return to Hanwell Institute | 30:52 |
| 8. |  Elenkoism | 371 | Serena | Part 4 | Shocking Revelation | 12:40 |
| 9. | Slail | 232 | Let's Play Serena - A One Part LP | 50:19 |
| 10. | bradye21 plays... | 224 | Let's Play Serena -3- Theres only one way anything can end (Finale) | 9:08 |
| 11. | 006Cronos | 222 | Let's Play: Serena (Part 2) | 16:33 |
| 12. |  Vinithian | 208 | Let's Play Serena Part 5 | 12:32 |
| 13. | Zalzar | 169 | Serena | IT BROKE MY HEART... | Gameplay Playthrough w/ facecam | 37:10 |
| 14. |  UbuntuGamingProject | 150 | Let's Play on Ubuntu: Serena (Steam) | 11:11 |
| 15. | Euclid | 139 | Let's Play Serena. Am I going crazy!? | 53:32 |
| 16. | EchoLP | 131 | Angespielt | Serena [Part 3/3] - "Nur benutzt...?" | Let's Play Serena | German | HD | 22:11 |
| 17. | ZokkerBunny Jey | 112 | SERENA #02 | Die Wahrheit kommt ans Licht ҳ̸Ҳ̸ҳ Let's Play Serena | 49:19 |
| 18. | Nessas Gamingzone | 110 | Plot-Twist! | Nessa spielt SERENA [Full Game] [Facecam, HD+] | 1:06:00 |
| 19. | TheIntendantS | 108 | Intendant S Plays Serena | 1:08:41 |
| 20. | l0stw0lf | 102 | Serena - Free Creepy Indie Point & Click Narrative - Part (3/3) FINAL - l0stw0lf plays | 16:42 |
| 21. |  Edgley Games | 93 | E's Laf - Gameplay with Serena (PC) [Playthrough/LongPlay] | 14:58 |
| 22. | Max Blackwing | 80 | Lets Play Serena: #To Spooky For Me!!~ | 53:20 |
| 23. | PoetryStud | 78 | Lets Play Serena - Indie Point and Click Game [#1] | 9:17 |
| 24. | CraigieG | 71 | Serena - Episode 2 - I finally understand....? | 16:39 |
| 25. | Rostbrot | 66 | Der Schrank | Let's Play Serena [German/Deutsch] #3 | 12:01 |
| 26. | Fussball mit Heel Phakdi | 53 | Serena Let's Play #005 - The End![HD+][Deutsch] | 10:57 |
| 27. | JAC OneManBand | 49 | Cabin In The Woods: JAC Plays: Serena | 50:29 |
| 28. | Gold Styles (Goldstyles) | 45 | Serena - FINALE - Let's Play - Capitolo 3 | 26:48 |
| 29. | Ragekitt | 38 | This Redditor did WHAT to his wife?! [Serena Playthrough] | 39:27 |
| 30. |  Orion Blair Phoenix Gaming | 38 | SERENA FULL INDIE GAME | 1:07:25 |
| 31. | spudheds | 33 | Spudheds Plays - Serena - Full playthrough | 41:09 |
| 32. | Avenclave | 27 | Let's Play SERENA #4 - Was für eine Tragödie! [Deutsch/German] | 18:44 |
| 33. |  Hybridjunkie | 26 | Let's Play - Serena | 43:47 |
| 34. | Tr1pw1re | 26 | The Truth Revealed! | Serena (PC) - Part 2 [End] | 23:50 |
| 35. |  SilverDarkPhoenix | 25 | Serena - Playthrough ( Please Shoot Me In The Head ) | 51:29 |
| 36. | iimjoeyy | 25 | SERENA FullPlaythrough! WHERE IS SERENA?! | iimjoeyy | 32:28 |
| 37. | Radedo | 25 | AM I GOING CRAZY TOO? - Let's Play Serena Full Gameplay | 1:20:51 |
| 38. | Nick Munger | 19 | Let's Play Serena | MESSED. UP. STUFF. | 32:14 |
| 39. | LanokirX | 17 | Serena | Full Playthrough | 35:37 |
| 40. |  ScarabD | 16 | Scarab plays: Serena [003-END] - The Armoire | 22:49 |
| 41. | ThrashingBunny | 16 | Serena let's play (full game) | 54:01 |
| 42. |  RAITSI | 13 | kabur dari sekolah hantu - dimensi lain serena - game horor indonesia | let's Play Gameplay | 18:23 |
| 43. | The Bigender Gamer | 12 | SERENA | Alex Replays | 40:41 |
| 44. | Emargy LPT | 11 | Let's Play Serena Part 02 - Enthüllungen - Finale | 29:12 |
| 45. | SqUiShY Gaming | 10 | Lost And Confused | Let's Play Serena | 22:43 |
| 46. | tacoline | 10 | Let's Play Serena pt 2 Fiery end | 28:11 |
| 47. |  TheLousyLoser | 9 | Unterwegs in Düsterburg | #29: Katzengasse Nr. 5 | PC | Let's Play | 32:46 |
| 48. | CorrosiveLick | 8 | Where did she go | Serena | CorrosiveLick Let's Play! | 21:18 |
| 49. | nekobun | 8 | Serena - Full Playthrough | 1:19:57 |
| 50. | Monmia | 5 | Let's Play an Indie Horror!_Serena [#2] | 17:28 |
| 51. | Spunkster | 5 | Serena - THE FEELS IS STRONG! - Full Playthrough | 34:55 |
| 52. | EmptyGarbageCan | 5 | Serena | 28:34 |
| 53. | wolfcub46 | 5 | Wolf Plays - Serena [Final] | 33:45 |
| 54. | IceAngelQueen | 4 | Ice Plays: Serena - Part 1 | 25:31 |
| 55. | MoonlitWenny | 4 | OH MY GOD | Let's Play Serena | 42:41 |
| 56. |  Jeajax | 3 | Let's play! Serena | 51:12 |
| 57. | Kraken | 3 | lets play serena click point adventure indie | 16:45 |
| 58. | Aul In | 3 | Serena - Full Play Through | 1:02:47 |
| 59. | NoAgendaStudios | 2 | Let's Play Serena | 1:07:04 |
| 60. | theRCLman | 0 | 🕵️We're Little DETECTIVES!!!🕵️ | Kika & Daigo A Curious Tale Let's Play (w/ Serena) | 32:11 |
