| 2024-08-02 |  gforceden10 | HELP (not a joke) I NEED HELP...progressing || The Binding of Isaac: Repentance | 4:07:20 | 22 |
| 2024-07-26 | OP | TBOI Repentance the forgotten plays with himself | 9:29 | 384 |
| 2024-07-01 | REALiNSaNgAMingGODPrODIgY | The Binding of Isaac: Rebirth No Commentary gameplay (Walkthrough / Playthrough / Lets Play) | 1:19:10 | 4 |
| 2024-06-30 | REALiNSaNgAMingGODPrODIgY | The Binding of Isaac: Rebirth No Commentary gameplay (Walkthrough / Playthrough / Lets Play) | 57:37 | 0 |
| 2024-06-29 | AbeClancy | Spider Mom - #378 - Abe Clancy Plays: The Binding of Isaac Repentance | 44:14 | 252 |
| 2024-06-28 | AbeClancy | Critical Mass - #377 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:02:55 | 261 |
| 2024-06-27 | AbeClancy | Reroll Me, I Dare You - #376 - Abe Clancy Plays: The Binding of Isaac Repentance | 58:11 | 208 |
| 2024-06-26 | AbeClancy | What's In The Bag? - #375 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:09:02 | 248 |
| 2024-06-20 | AbeClancy | It's Rude to Point - #373 - Abe Clancy Plays: The Binding of Isaac Repentance | 47:18 | 248 |
| 2024-06-19 | AbeClancy | Snek Bite - #372 - Abe Clancy Plays: The Binding of Isaac Repentance | 43:30 | 259 |
| 2024-06-17 | AbeClancy | Conspicuous Consumption - #370 - Abe Clancy Plays: The Binding of Isaac Repentance | 53:14 | 199 |
| 2024-06-16 | AbeClancy | I Studied the Blade - #369 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:20:57 | 257 |
| 2024-06-14 | AbeClancy | Actual Isaac - #367 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:22:17 | 282 |
| 2024-06-13 | AbeClancy | Tractor Bomb - #366 - Abe Clancy Plays: The Binding of Isaac Repentance | 55:55 | 209 |
| 2024-06-12 | AbeClancy | Moving Box - #365 - Abe Clancy Plays: The Binding of Isaac Repentance | 2:26:44 | 314 |
| 2024-06-11 | AbeClancy | Hush - #364 - Abe Clancy Plays: The Binding of Isaac Repentance | 43:03 | 222 |
| 2024-06-10 | AbeClancy | Mimic - #363 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:33:57 | 251 |
| 2024-06-09 | AbeClancy | Sanguine - #362 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:21:06 | 233 |
| 2024-06-08 | AbeClancy | adimhvoslhsoai - #361 - Abe Clancy Plays: The Binding of Isaac Repentance | 46:38 | 207 |
| 2024-06-07 | AbeClancy | Apology Accepted - #360 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:27:58 | 261 |
| 2024-06-06 | AbeClancy | Critical Mass - #359 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:12:54 | 231 |
| 2024-06-05 | AbeClancy | Pong - #358 - Abe Clancy Plays: The Binding of Isaac Repentance | 56:49 | 168 |
| 2024-06-04 | AbeClancy | Attack of the Radioactive Babies - #357 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:01:48 | 197 |
| 2024-06-02 | AbeClancy | Salvation - #355 - Abe Clancy Plays: The Binding of Isaac Repentance | 47:42 | 163 |
| 2024-05-30 | AbeClancy | He's Out For Blood! - #352 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:03:04 | 144 |
| 2024-05-28 | AbeClancy | Balanced - #350 - Abe Clancy Plays: The Binding of Isaac Repentance | 57:30 | 144 |
| 2024-05-27 | AbeClancy | DOWN BOY - #349 - Abe Clancy Plays: The Binding of Isaac Repentance | 59:18 | 203 |
| 2024-05-25 | AbeClancy | Consecutive Normal Punches - #347 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:28:34 | 198 |
| 2024-05-23 | AbeClancy | Two Esaus Are Better Than One - #345 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:02:10 | 136 |
| 2024-05-22 | AbeClancy | Spider Machine Gun - #344 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:20:08 | 200 |
| 2024-05-21 | AbeClancy | Fly Guy - #343 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:36:52 | 200 |
| 2024-05-19 | bisnap | Isaac to help me recover from surgery | 2:41:04 | 1,297 |
| 2024-05-18 | AbeClancy | 3RR0R - #341 - Abe Clancy Plays: The Binding of Isaac Repentance | 46:53 | 147 |
| 2024-05-16 | AbeClancy | Splash Damage - #339 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:04:49 | 133 |
| 2024-04-30 | Sinvicta | When #isaac plays nice?! - The Binding Of Isaac: Repentance #1034 #isaacrepentance #bindingofisaac | 1:12:59 | 47,510 |
| 2024-04-28 | picklechip27 | Kairo Plays: The Binding of Isaac Repentance | 19:32 | 3 |
| 2024-04-16 | Hutts | HELP I have 2 dogs here | 5:51:59 | 11,578 |
| 2024-04-16 | mrcrunches | THE GOAT PLAYS ISAAC (I dont know what im doing) | 3:14:08 | 18 |
| 2024-04-08 | TimeToGrind | Doubling Enemies in Isaac is NOT THE PLAY | 0:22 | 11,788 |
| 2024-03-30 | Reldrik | These Games Broke My Brain - Investigator and Shadowside Full Game Playthroughs | 5:34:54 | 88 |
| 2024-03-24 | Pursuing Pixels | Caves of Eternity // #PursuingPixels #indiegames #retrogaming | 0:51 | 474 |
| 2024-03-20 | TimeToGrind | My First Time Playing A TAINTED CHARACTER in Isaac! | 1:34:21 | 215 |
| 2024-02-24 | TimeToGrind | FINALLY GOING HOME & Unlocking Tainted Characters In Repentance! | 1:24:59 | 211 |
| 2024-02-24 | REALiNSaNgAMingGODPrODIgY | GOD SEED RUN???? gameplay (Walkthrough / Playthrough / Lets Play) | 50:16 | 70 |
| 2024-02-22 | HeyAmethystMay | Can we Ever Escape? [CC] [18+] | 2:04:22 | 30 |
| 2024-02-09 | HyperHimes | How Many Familiars Is TOO MANY?! (The Binding Of Isaac) #Shorts #TheBindingOfIsaac #Gameplay #Funny | 0:32 | 2,412 |
| 2024-01-31 | HeyAmethystMay | We made it to the depths! [CC] [18+] | 2:04:52 | 49 |
| 2024-01-28 | HeyAmethystMay | This game is interesting! #vtuber #bindingofisaac #shorts | 0:24 | 2,327 |
| 2024-01-26 | AbeClancy | Blood Rights - #338 - Abe Clancy Plays: The Binding of Isaac Repentance | 52:06 | 257 |
| 2024-01-25 | AbeClancy | Oh, Brother - #337 - Abe Clancy Plays: The Binding of Isaac Repentance | 54:42 | 260 |
| 2024-01-24 | HeyAmethystMay | What is BELOW the Caves in Binding of Isaac Rebirth? [CC] [18+] | 0:00 | 42 |
| 2024-01-24 | WaybackGuy | EVE IS HERE ! The Binding Of Isaac [PC] (First Play) WAYBACKGUY | 44:24 | 13 |
| 2024-01-23 | HeyAmethystMay | Time for a restraining order! #vtuber #bindingofisaac #shorts | 0:31 | 14 |
| 2024-01-22 | AbeClancy | Satan and the Egg - #5 - Abe Clancy Plays: Bloody Hell | 19:02 | 123 |
| 2024-01-18 | Rydo | LOCKED New or Trending Game | 0:00 | 0 |
| 2024-01-17 | HeyAmethystMay | Can WE get past Cave 1 in Binding of Isaac: Rebirth? [CC] [18+] | 2:27:57 | 38 |
| 2024-01-17 | Nicky & Jay Plays YT | 🔴 LIVE - [THE BINDING OF ISAAC] gameplay! chat! coop! playthrough! | 1:07:43 | 30 |
| 2024-01-14 | Nicky & Jay Plays YT | 🔴 LIVE - [THE BINDING OF ISAAC] gameplay! coop! playthrough! | 2:03:30 | 6 |
| 2024-01-12 | Luna Solarys | Harassing a Slimegirl in Binding of Isaac Rebirth ONLINE CO-OP | VTuber Playthrough Collab | 3:40:05 | 87 |
| 2024-01-11 | WaybackGuy | MORE ISSAC ! The Binding Of Isaac [PC] (First Play) WAYBACKGUY | 1:26:28 | 26 |
| 2024-01-10 | HeyAmethystMay | Clip Championship then First Look at The Binding of Isaac Rebirth! [CC] [18+] | 2:04:59 | 38 |
| 2024-01-04 | WaybackGuy | LAZARUS AND AZAZEL ! The Binding Of Isaac [PC] (First Play) WAYBACKGUY | 24:49 | 41 |
| 2024-01-03 | Nicky & Jay Plays YT | 🔴 LIVE - NICKY and Jay plays [The Binding of Isaac] DLC | 41:38 | 9 |
| 2024-01-02 | WaybackGuy | 3 STRIKES LAW ! The Binding Of Isaac [PC] (First Play Deaths) | 0:26 | 78 |
| 2023-12-30 | Astrial | You Can't Unaddict My Addiction To This Game! Help! | 10:00:00 | 42 |
| 2023-12-29 | WaybackGuy | REBIRTH AND REPENT ! The Binding Of Isaac [PC] (First Play) WAYBACKGUY | 1:16:29 | 138 |
| 2023-12-21 | Matrixlord212 | Matrixlord212 Plays | 20:34 | 20 |
| 2023-11-26 | AwktheAngel | THE BINDING OF ISAAC: REBIRTH - FIRST PLAYTHROUGH | 1:21:30 | 31 |
| 2023-11-22 | Sneed Plays | Beating Ultra Greed with Apollyon | The Binding Of Isaac: Repentance | Sneed Plays | 3:50 | 216 |
| 2023-11-21 | TimeToGrind | My Viewers HACKED INTO MY GAME in Binding Of Isaac! | 1:05:39 | 296 |
| 2023-11-20 | Astrial | I'm NOT Addicted To Stardew Valley I Promise! (help) | 7:28:04 | 64 |
| 2023-11-07 | DarekB52 | VERY Easy Gurdy Fight - Bards Note | 0:42 | 55 |
| 2023-11-05 | Reldrik | Can't Sleep So Lets Play Trackmania | 3:32:50 | 104 |
| 2023-11-02 | Reldrik | Newbie Plays Trackmania | 2:18:11 | 188 |
| 2023-10-29 | Crimson Solstice | The Dishwaher: Let's Play | 1:59:58 | 7 |
| 2023-10-05 | AbeClancy | Abe Clancy Plays: The Binding of Isaac Repentance - #336 - Brotherly Love | 54:14 | 262 |
| 2023-10-04 | AbeClancy | Abe Clancy Plays: The Binding of Isaac Repentance - #335 - Take A Drink | 1:12:40 | 327 |
| 2023-10-01 | Gam Trail | Dev Thoughts 28 Risk of Rain Returns | 4:01 | 21 |
| 2023-09-24 | Lexuu | deepwoken player plays binding of issac p2 | 0:00 | 0 |
| 2023-09-19 | SoraSun | I Regret doing this in Isaac pls send Help. | 9:11 | 2,581 |
| 2023-09-13 | DarekB52 | Isaac VS Bony - Bards Note | 0:19 | 7 |
| 2023-09-04 | LoneWolf Gaming | the binding of isaac full game | 25:46 | 11 |
| 2023-08-11 | TimeToGrind | Isaac's got some pretty interesting bosses 👀 | 0:53 | 545 |
| 2023-08-07 | VaderMater | Playing The Binding of Isaac | First Playthrough | 1:09:35 | 12 |
| 2023-08-06 | AbeClancy | Abe Clancy Plays: The Binding of Isaac Repentance - #334 - Diplopia | 52:24 | 306 |
| 2023-08-01 | Jacob Qwerty | The Binding of Isaac: Repentance/Wrath of The Lamb Blind Playthrough | 2:01:05 | 51 |
| 2023-07-31 | Bum Chadda | Let's Play The Binding of Isaac Afterbirth+ [Eden Hard Mode Run] [Part 4] | 8:44 | 13 |
| 2023-07-30 | Lagavulan | Jacob and Esau Isaac Repentance Helpful Tip #5 #shorts | 0:14 | 4,737 |
| 2023-07-29 | Lagavulan | Tear Delay Isaac Repentance Helpful Tip #4 #shorts | 0:12 | 1,052 |
| 2023-07-28 | Lagavulan | Cracked Crown Isaac Repentance Helpful Tip #3 #shorts | 0:12 | 1,532 |
| 2023-07-27 | Lagavulan | 2 Brimstones Isaac Repentance Helpful Tip #2 #shorts | 0:12 | 1,121 |
| 2023-07-26 | Lonslo | This New Isaac Character Helps You Touch Grass | 11:18 | 16,232 |
| 2023-07-26 | Lagavulan | Soul Heart Isaac Repentance Helpful Tip #1 #shorts | 0:12 | 1,981 |
| 2023-07-25 | AbeClancy | Abe Clancy Plays: The Binding of Isaac Repentance - #333 - Better Than Apollyon | 1:05:32 | 335 |
| 2023-07-24 | Jacob Qwerty | The Binding of Isaac: Wrath of The Lamb Blind Playthrough | 1:04:40 | 29 |
| 2023-07-16 | Jacob Qwerty | BIG BOI UN-BOXING! The Binding of Isaac: Four Souls Requiem Playthrough | 1:49:30 | 76 |
| 2023-07-13 | eradicate_bread | The Binding of Isaac Repentance - Episode 72 (Full Playthrough) | 1:06:55 | 3 |
| 2023-07-12 | eradicate_bread | The Binding of Isaac Repentance - Episode 71 (Full Playthrough) | 53:40 | 1 |
| 2023-07-10 | Bum Chadda | Let's Play The Binding of Isaac Afterbirth+ [Eden Hard Mode Run] [Part 3] | 8:27 | 15 |
| 2023-07-05 | Cackling Pumpkins | Rivet Plays The Binding of Isaac: Rebirth | 2:16 | 308 |
