| 1. |  DanTDM | 122,722,899 | BABY NEWS... (Tomodachi Life #36) | 56:02 |
| 2. |  Poofesure | 50,357,180 | Matt is Freaky on Tomodachi Life Season 2 | 10:56 |
| 3. | LaurenZside | 32,872,018 | I ERASED Everyone's Memories in Tomodachi Life to Cause DRAMA AGAIN | 12:23 |
| 4. |  ドコムスチャンネル | 30,276,413 | 【生放送】「トモダチコレクション新生活」実況プレイ第４７回 | 0:00 |
| 5. | コアラ's GAME SHOW | 25,938,476 | トー横からヤバい彼女候補がやってきた【トモダチコレクション新生活 コアララモテモテ島】 | 11:25 |
| 6. | OhhMyKawaii | 24,535,548 | when the audio is cringe and glitchy | 0:35 |
| 7. | Swimming Bird | 16,979,811 | Miitopia PART 1 - Tomodachi Quest RPG - Dark Lord Mickey - Nintendo 3DS Demo Gameplay Walkthrough | 32:40 |
| 8. |  LETSPLAYmarkus | 16,876,568 | TOMODACHI LIFE [STAFFEL 2] # 26 🏘️ Mach dich zum Affen! | 35:59 |
| 9. | アブ -abu- | 15,978,157 | 【悲報】負の遺伝子を色濃く受け継いでしまった息子が悲惨すぎる…。【トモダチコレクション新生活】 | 14:24 |
| 10. | YuB | 15,811,183 | no context tomodachi life #1 | 18:07 |
| 11. | xXSlyFoxHoundXx | 11,114,731 | THE BETTER TOMODACHI LIFE? - Nintendo Animal Crossing Direct Reaction. | 16:12 |
| 12. | あゆなチャンネル | 10,320,773 | 激しすぎる夫婦喧嘩【トモダチコレクション新生活】 | 15:44 |
| 13. | SullyPwnz | 9,988,910 | Tomodachi Life - Episode 8: Tommy Joins The Island! | 29:02 |
| 14. |  Lili Cross | 8,725,925 | CASTIEL Y DAIN... AMIGOS O RIVALES POR MI AMOR? | Ep.04 | TOMODACHI LIFE | 28:49 |
| 15. | Sagemaster15 | 7,852,528 | When I'm bored with Heroes, welcome to this hell instead. | 20:57 |
| 16. | しゅうゲームズ | 7,226,379 | メイクができる最新のゲームがやばい | 7:49 |
| 17. | vinesauce | 7,132,393 | [Vinesauce] Vinny - Tucker Friendperson (Best Of) | 11:41 |
| 18. |  지컨 | 7,106,649 | 지컨의 「친구모아 아파트」 - 25 그 박사의 고백법 | 10:42 |
| 19. |  KeNoia | 6,784,927 | TEST dell' AMORE tra MORTINA e COOKIE - Tomodachi Life | 11:25 |
| 20. | InTheLittleWood | 6,148,589 | Tomodachi Life: Kiki And Pascal Invade!! - Part 35 | 15:07 |
| 21. | PeanutButterGamer | 6,022,468 | Tomodachi Life - PBG | 7:32 |
| 22. |  Call Me Kevin | 5,912,463 | My Tomodachi Life cinematic universe is insane | 15:02 |
| 23. |  Rabbit OST | 5,785,047 | Tomodachi Life OST 'Staff Roll' | 2:57 |
| 24. | Nintendo of America | 4,959,751 | Nintendo 3DS - Holiday Wish List - with Reggie and the ELVES | 1:40 |
| 25. |  Guillaume & Kim | 4,952,364 | ON JOUE A QUI EST-CE ? (Avec des Mii) ! | 25:35 |
| 26. | AbdallahSmash | 4,552,893 | Abdallah Smash #BirthdayBash2016! Party With Subscribers! | 2:46:28 |
| 27. | Chadtronic | 4,401,091 | Ugly Mii Making | 3:17 |
| 28. | Centrixe the Dodo | 4,374,284 | Tomodachi Life Music – Returning Traveler | 5:04 |
| 29. | YOGSCAST Zoey | 3,898,618 | Tomodachi Life - Mushbury Island's Greatest Hits! | 17:44 |
| 30. | Vappyvap88 | 3,744,861 | [Vinesauce] Vinny || MGS: Phantom Pains - [Break] - Tomodachi Life + Weird (Pre-Stream) | 7:10 |
| 31. | Bijuu Mike | 3,682,566 | Answering your spicy questions | 22:56 |
| 32. | Bibi TM | 3,389,499 | [Chez BibiTm] Tomodachi Life - Simon a bien grandi ! (Partie 13) | 26:32 |
| 33. | PointlessBlogGames | 3,282,409 | YouTubers Fall In LOVE... | YouTuber Island #4 | 12:55 |
| 34. | Nintendo España | 2,983,131 | Tomodachi Life - Disfruta de las Navidades en Tomodachi Life (Nintendo 3DS) | 0:21 |
| 35. | パンパンやりすぎch【生放送系】 | 2,775,799 | 【トモコレ】俺が大学生になって作った曲がやばすぎる | 0:45 |
| 36. | LewSaber | 2,774,765 | Tomodachi Life Song: The Last Performance | 15:35 |
| 37. | Vinesauce: The Full Sauce | 2,769,566 | [Vinesauce] Vinny - Tomodachi Life: April Fools' Special! (part 57) | 1:37:09 |
| 38. | Tearless Raptor | 2,762,740 | Ho vissuto la Vita di un Gatto su BitLife | 14:01 |
| 39. | Saltydkdan | 2,660,167 | Tomodachi Life in 2022 | 24:57 |
| 40. | Crystal Dreams | 2,547,613 | Tomodachi Life: Another check-in | 33:53 |
| 41. | TheBitBlock | 2,481,680 | Journal - Tomodachi Life | The Summer Re-Visit! | 33:29 |
| 42. | DAEJEE GAMING | 2,466,698 | [Ep48] Tomodachi Life: C'est la Glandouille ! | 20:28 |
| 43. | leven | 2,411,577 | SIEMPRE TE ESTARÉ ESPERANDO #66 TOMODACHI LIFE CON SUSCRIPTORES | 28:11 |
| 44. | レトルト | 2,402,324 | 変人たちの生活をのぞき見るゲーム『トモダチコレクション 新生活』 | 6:38:58 |
| 45. | TheGamedawg | 2,167,354 | Tomodachi Life - All treasure collected | 0:55 |
| 46. | Farez Naqiuddin | 2,150,333 | Tomodachi Life - Mii News - José Turns 46 | 1:08 |
| 47. | TV대정령 | 1,881,449 | [PD대정령] 관절이 아파와 | 2:48 |
| 48. |  Ronald | 1,862,143 | 😡DIT 😡 SPEL 😡 HAAT 😡 ME! 😡 | 11:03 |
| 49. | The Escapist | 1,841,671 | Tomodachi Life - Nintendo Life Simulator (Zero Punctuation) | 5:09 |
| 50. | RTGame | 1,791,918 | Tomodachi Life Is Incredibly Cursed | 10:23 |
| 51. | NintenDaan | 1,672,116 | [eShop EU] The Cat Mario Show - Episode 12 | 9:51 |
| 52. | stratussina | 1,555,191 | Tomodachi life live speciale 11 feb | 1:00:07 |
| 53. | Ana Destino | 1,524,905 | TOMODACHI LIFE T.6 #02 - PRIMEROS RECADOS - ISLA TAMARINDO | 25:09 |
| 54. | ナポリの男たち | 1,509,904 | ナポリの男たちのトモダチコレクション | 1:08:57 |
| 55. | AnimeBroMii | 1,443,684 | Tomodachi Life!! Tomodachi is back 6 years later!! 2 New Guest Debut!?! (Episode 11) | 23:55 |
| 56. |  Anton Retro | 1,348,129 | How to Homebrew Your New Nintendo 3DS & 2DS (11.17) | 13:48 |
| 57. | ChilledChaos | 1,218,724 | A Derp Crew Love Story (Nintendo 3DS: Tomodachi Life - Part 11) | 33:00 |
| 58. | NintendoItalia | 1,204,693 | Il Mario Gatto Show - Episodio 5 | 7:19 |
| 59. |  Jodie Dreams | 1,173,083 | ACNL et Tomodachi Life INFOS IMPORTANTE! | 7:00 |
| 60. | PixelsByNight | 1,164,904 | Is Everything Random? | Tomodachi Life | 17:59 |
| 61. | HelldogManquess! | 1,142,965 | Tomodachi Life! Capitulo 34! | 22:12 |
| 62. | ドラにし, | 1,023,739 | 小学生の頃に『トモダチコレクション新生活』で作った曲が超ド下ネタ級神曲ソングでした。【第二弾】#shorts | 0:59 |
| 63. | Nintendo Girls Club | 1,002,489 | Tomodachi Life - Hilarious Histories (Nintendo 3DS) | 0:31 |
| 64. | McBustedeon | 996,251 | TomoDachi Life Funny Music Hall performance Montage 2 (reuploaded) | 25:52 |
| 65. | Pomu Rainpuff 【NIJISANJI EN】 | 973,969 | 【TOMODACHI LIFE】just a little tomfoolery island life【NIJISANJI EN | Pomu Rainpuff】 | 2:13:53 |
| 66. | AdamzoneTopMarks | 962,120 | Super Mario VS Sans Top 5 RAP BATTLES ft. Peach, Luigi & Bowser Miis (3DS) | 8:57 |
| 67. | Floralie | 943,756 | [Tomodachi Life] : BONNE RENTRÉE À TOUS !!!!!! | 27:42 |
| 68. | The Gaming Otter | 936,828 | Tomodachi Life New Baby #nintendo #nintendo3ds #tomodachilife #streetpass | 0:56 |
| 69. | GameXplain | 929,847 | Top 10 BEST Nintendo Direct Moments! (10 Year Anniversary) | 13:16 |
| 70. | TommyVODS | 887,756 | Tommy Makes Molly In Tomodachi Life... | 1:08:48 |
| 71. | 풍월량 | 866,438 | 오버워치 한조가 부르는 한맺힌 오페라 - 친구모아 아파트 [풍월량] | 13:30 |
| 72. |  CrazyVideoGammer | 839,533 | Para que SIRVE el Infrarrojo en una Nintendo 3DS / XL y 2DS? (TIKTOK) #shorts | 0:44 |
| 73. | Huebi | 826,865 | Das Kind von Ari und Kuebi ist erwachsen! [ENDE] | 18:11 |
| 74. | Japancommercials4U2 | 808,782 | Tomodachi Life - Interiors Showcase | 21:53 |
| 75. | Nintendo France | 794,492 | Le show de Mario chat - Épisode 33 | 6:06 |
| 76. | Nintendo3DSuk | 782,216 | Tomodachi Life - "Majora's Mask" Song (Nintendo 3DS) | 1:00 |
| 77. | KawaiiBeth | 746,787 | Will New Day REPLACE Tomodachi Life 2?? | 5:17 |
| 78. | ChocolateMilkGamer | 741,196 | Tomodachi Life Funny Moments Finale: Jay Leno's Confession - Chocolate Milk Gamer | 6:14 |
| 79. | 로나딩 | 722,305 | 🐱고양이가 된 멜로딩! [친구모아아파트 21화] | 9:26 |
| 80. | Brown Studios | 718,340 | Welcome to Brownie Island, Ron Swanson | Tomodachi Life | 25:37 |
| 81. | Alex CND | 698,780 | The Best Mii QR Codes! | 3:25 |
| 82. | mienah | LIVE | 697,463 | 42 Streamer in einem Haus und 2 KRIEGEN EIN KIND? | 12:12 |
| 83. | WoloU | 691,754 | Let's Play Tomodachi Life - Part 66 | 13:39 |
| 84. | YOGSCAST Kim | 678,762 | TOMODACHI LIFE! Yog Metal! (#3) | 17:39 |
| 85. | dydy | 670,780 | Die LETZE Folge TOMODACHI LIFE... (ENDE) | 30:36 |
| 86. | CubeGame | 667,988 | みんなのトモダチコレクション新生活あるある＆おもいで | 8:11 |
| 87. | ChequioProGamer | 664,350 | TOMODACHI LIFE | PARTE #4 | ¡DISFRAZ DE HÁMSTER! XD | Chequio | 17:38 |
| 88. | Danikyo Shorts | 645,426 | ¿Qué pasa en tu cumpleaños en juegos de Nintendo? Tomodachi Life | 0:45 |
| 89. | LissyGaming | 638,291 | Darum KEIN Animal Crossing/Tomodachi Life MEHR! | 4:40 |
| 90. | Blizzeatos | 633,131 | Verkleidet als Baby! ENDE! ✧ #61 Tomodachi Life Deutsch German Let's Play | 15:48 |
| 91. | Marc The Geek | 628,434 | New Nintendo 3DS XL: Adding a 32GB MicroSD | 8:45 |
| 92. | ぐっちの部屋(ミラクルぐっち) | 605,221 | マツコと付き合うことになりましたｗｗ恋のキューピットはまさかの人！？トモダチコレクション・新生活♯３ | 26:21 |
| 93. | That Video Games Show | 588,001 | Ten Underrated 3DS Games | 11:01 |
| 94. |  Игорь Линк | 586,636 | NINTENDO - ЭТО СЕКТА | 13:07 |
| 95. | Balui | 582,708 | ENDLICH EINE HOCHZEIT??? - Tomodachi Life - Staffel 2 - #17 | 15:50 |
| 96. | Bearman3600 | 545,951 | Xhamster Island's Inhabitants #tomodachilife #3ds #nintendo | 1:01 |
| 97. | KENT for 任天堂ゲームレビュー | 539,024 | ガチで共感する！ニンテンドー3DSあるある60連発【2024年最新版】 | 11:19 |
| 98. | Zack Jewell | 531,695 | Tomodachi Life - Mii News - World Ammonite Fossil Show | 0:36 |
| 99. | ころんの実況【すとぷり】 | 527,817 | すとぷり様には本当にお世話になっております。【ころん】すとぷり | 12:55 |
| 100. | DPadGamer | 526,325 | A Fever Dream of Easter Eggs in Tomodachi Life - DPadGamer | 15:41 |
