A Comprehensive Review of Ribosomal Hibernation & Associated Factors in Escherichia coli | Bacteria
0A Comprehensive Review of Ribosomal Hibernation and Associated Factors in Escherichia coli
Layman Abstract : Bacteria have developed smart ways to survive harsh conditions like lack of nutrients, temperature changes, and acidity shifts. One key survival trick is converting their active ribosomes (which make proteins) into an inactive form called 100S ribosomes, helping them conserve energy during stress. Recent studies have revealed the detailed structure of these 100S ribosomes, improving our understanding of how bacteria (Escherichia coli) enter a "hibernation" state.
In E. coli, two proteins—Ribosome Modulation Factor (RMF) and Hibernation-Promoting Factor (HPF)—help form these inactive ribosomes. Their production is controlled by various signals, such as nutrient shortages and energy levels. A molecule called (p)ppGpp plays a major role in this process by slowing down ribosome production when bacteria face stress. Since ribosomal hibernation is crucial for bacterial survival, studying how these proteins work could help in designing better antibiotics to target bacteria more effectively.
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Related keyword:
Escherichia coli
Ribosome hibernation in bacteria
100S ribosome structure and function
Bacterial stress response mechanisms
Ribosome modulation factor (RMF) and HPF
Translational control in bacteria
Stress-induced ribosomal dormancy
(p)ppGpp signaling in bacteria
Escherichia coli ribosome adaptation
Bacterial survival strategies
Ribosome cycle and stress response
Biofilm formation and translation regulation
Metabolic adaptation in bacteria
Bacterial gene regulation under stress
Environmental adaptation in E. coli
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Antibiotic resistance and ribosome hibernation