Assassin's Creed Brotherhood The Apple of Eden (Full Synch)
Full synchronization guide to the mission "The Apple of Eden". OK, here's the bad parts of this mission: you can't use any weapons or smoke bombs while holding the Apple (yeah, this sucks!). You absolutely should NOT use the Apple Charge attack as that drains health and breaks the Full Synch requirement. You can however, do a single click attack with the Apple to stun any enemies about to strike you (this is your only form of defense). Now that is all over with, just run for the river! Good luck!
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