Plenty of differences here. Some for the worse, some for the better. First, let's talk about the electric scientists. Here, they don't do anything before you attack them, so they're much easier to approach. However, they might try to electrocute you when they start approaching you, so be careful. Also, there's a glitch that makes you take damage if you kill them while facing them. You need to face the other way to avoid damage.
The slow doors you need to wait for are very annoying and I'm glad they removed them from the finished game. The design is also different. Also, some places, there is no electricity at all, making it much easier, and the yellow blobs don't always appear. Finally, there are no boxes except for the checkpoints and the finishing area is completely different.
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