Design and Synthesis of Nucleoside Analogues as Potent GOT Enzyme Inhibitors | Enzyme Inhibition
0Design, Synthesis, and Evaluation of Nucleoside Analogues as Potent Inhibitors of the GOT Enzyme
Layman Abstract : Two primary sections were investigated in this study. The synthesis of new Mannich derivatives of the nucleoside cytidine is the main topic of the first section. This is accomplished by reacting cytidine with secondary amines, namely morpholine, pyrazine, pyridine, and pyrrolidine, while formaldehyde is present. Nucleoside analogues (1, 2, 3, and 4) are produced by this procedure, and their structural integrity is then verified by FTIR spectroscopy, ¹³C NMR, and ¹H NMR characterization. The second section assesses how these synthetic substances affect the activity of glutamate oxaloacetate transaminase (GOT) in human serum samples. Under the same circumstances, enzyme activity is assessed both with and without the inhibitors. The most effective inhibitors are found, the inhibition mechanism is ascertained, and the inhibition ratios are computed. The findings emphasize the potential of the synthesized nucleoside analogues as Enzyme Inhibition by showing that they have strong inhibitory effects against GOT.
View Book: https://bookstore.bookpi.org/
#GOT #NucleosideAnalogous #EnzymeInhibition #MannichDerivatives #InhibitionMechanism
#MannichReaction #NucleosideAnalogues #CytidineDerivatives #syntheticchemistry #HeterocyclicCompounds #SmallMoleculeSynthesis #drugdiscovery #medicinalchemistry #MolecularInhibitors #EnzymeInhibition
Related keyword:
🧪 Top YouTube SEO Keywords:
Mannich reaction cytidine
Synthesis of nucleoside analogues
Cytidine derivatives synthesis
Mannich base reaction mechanism
FT-IR NMR cytidine derivatives
¹H NMR of nucleoside analogues
GOT enzyme inhibition
Glutamate oxaloacetate transaminase inhibitors
Cytidine Mannich base inhibitors
Nucleoside analogues as enzyme inhibitors
Biochemical activity of cytidine derivatives
Structure activity relationship nucleosides
Enzyme inhibition mechanism
Medicinal chemistry Mannich reaction
Targeting GOT enzyme with analogues