This was my first attempt on the hardest mode after completing a 1 CC on Normal (no continues lost). I will have a tutorial with commentary up for that run soon. I was just fucking around to see what the hardest mode was like. If I decide to beat this mode I would do more in-depth practice with save states.
This mode was considerably harder but not a massive jump in difficulty. The biggest issue is increased damage taken from bosses which is a huge problem since minions constantly interrupt those fights. The bosses all have simple patterns otherwise when alone.