Its often a good idea to take over as many bases as possible. When you take over all the bases in an area it stops re inforcements from coming in. They can work thier way into the home base area and win the game if you dont keep an eye on where they are, but you can atleast stop re inforcements in the area you take over completely.
This stops working after you take over 2 bases for this mission since there is a special order which allows enemies to appear anywhere. So I left a tank on my home base to take out whatever appeared and got a lancer unit behind the boss tank to kill it easily.