Why do some hormones need to trigger a 'second messenger' to activate a target cell? (A) The hor...

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Why do some hormones need to trigger a 'second messenger' to activate a target cell?
(A) The hormone needs activation of ATP
(B) The first messenger cannot cross a plasma membrane
(C) There are no specific cell surface receptors for hormones
(D) The first messenger is not a water soluble molecule
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