Top 100 The Binding of Isaac: Rebirth Videos With The Longest Duration by Shadow's Twitch-sanity
| Video Title | Duration | Category | Game | |
|---|---|---|---|---|
| 1. | [The Binding of Isaac] The Realm's Descent to Madness | 2:42:22 | The Binding of Isaac: Rebirth | |
| 2. | [The Binding of Isaac] Apex's Ascension | 2:35:56 | The Binding of Isaac: Rebirth |