| Uridium 2 (1993) | 60,114 | 41 |
| Urlaubs Raser (2000) | 115,298 | 66 |
| URO (2018) | 165,638 | 53 |
| URO2 (2019) | 9,429 | 14 |
| Ursine Science (2023) | 216 | 3 |
| Urthwurm (2002) | 99 | 2 |
| Urtuk: The Desolation (2021) | 1,299,997 | 1,904 |
| Uru: Ages Beyond Myst (2003) | 468,078 | 389 |
| Uru: The Path of the Shell (2004) | 7,710 | 84 |
| Uru: To D'ni (2004) | 18,494 | 29 |
| Ururun Quest: Koiyuuki (2005) | 6,097 | 73 |
| Urusei Yatsura (1987) | 7,732,287 | 1,052 |
| Urusei Yatsura: Dear My Friends (1994) | 77,864 | 76 |
| Urusei Yatsura: Endless Summer (2005) | 7,889 | 9 |
| Urusei Yatsura: Lum's Wedding Bell (1986) | 101,888 | 30 |
| Urusei Yatsura: Stay With You (1990) | 23,382 | 45 |
| Uruz: Return of the Er Kishi (2020) | 499,887 | 51 |
| USAAF Mustang (1990) | 154,920 | 265 |
| Usagi Health Club (2022) | 2,815 | 3 |
| Usagi na Panic (1995) | 5,142 | 7 |
| Usas (1987) | 139,705 | 125 |
| The USB Stick Found in the Grass (2021) | 27,918 | 10 |
| USC: Counterforce (2023) | 392,067 | 255 |
| USD Clicker (2024) | 0 | 0 |
| The Use of Life (2022) | 159,862 | 253 |
| Use Your Words (2017) | 23,080,103 | 1,023 |
| Used Cars Simulator (2025) | 4,859,176 | 795 |
| Ushio to Tora (1993) | 416,109 | 144 |
| UsoNatsu ~The Summer Romance Bloomed From A Lie (2023) | 19,279 | 48 |
| Uspavanka (2023) | 110,974 | 5 |
| USSR CHAN: Hentai Puzzle Game (2021) | 0 | 0 |
| Usual June (2025) | 27,130 | 62 |
| Usurper: Soulbound (2021) | 49,665 | 102 |
| Utacchi (2010) | 15,687 | 11 |
| Utawarerumono Zan (2018) | 1,413,371 | 1,591 |
| Utawarerumono: Mask of Deception (2015) | 2,421,258 | 3,427 |
| Utawarerumono: Mask of Truth (2016) | 4,235,120 | 3,172 |
| Utawarerumono: Prelude to the Fallen (2002) | 437,282 | 1,506 |
| The Utility Room (2023) | 185,666 | 73 |
| Utopia (1981) | 55,874,420 | 4,081 |
| Utopia City (2006) | 122,807 | 25 |
| Utopia Must Fall (2024) | 73,167 | 107 |
| Utopia: The Creation of a Nation (1991) | 145,584 | 142 |
| Utsurun Desu.: Kawauso Hawaii e Iku!!! (1992) | 133,228 | 39 |
| Uujai no Tegami Chou (2007) | 0 | 0 |
| Uuno Turhapuro muuttaa maalle (1986) | 101,002 | 30 |
| Uurnog (2017) | 65,647 | 114 |
| UwiTron (2005) | 0 | 0 |
| UwU Hunter (2025) | 40 | 1 |
| Uzu Keobukseon (1992) | 79,268 | 77 |
