| S H R i M P (2020) | 1,340 | 5 |
| S*M*A*S*H*E*D (1987) | 1,633,411 | 215 |
| S.A.I.A.'s Awakening: A Robothorium Visual Novel (2019) | 64 | 6 |
| S.C.A.R.S. (1998) | 21,016,294 | 552 |
| S.C.A.T.: Special Cybernetic Attack Team (1990) | 834,761 | 598 |
| S.C.OUT (1992) | 1,139,297 | 112 |
| S.D.I. (1986) | 0 | 0 |
| S.E.C.U. (2022) | 117,456 | 177 |
| S.L.A.I.: Steel Lancer Arena International (2005) | 8,797,112 | 401 |
| S.O.N (2019) | 10,707,662 | 83 |
| S.T.A.L.K.E.R. 2: Heart of Chernobyl (2024) | 738,697,918 | 137,112 |
| S.T.A.L.K.E.R.: Call of Pripyat (2009) | 856,847,848 | 115,572 |
| S.T.A.L.K.E.R.: Clear Sky (2008) | 325,073,701 | 42,055 |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (2007) | 846,272,772 | 130,209 |
| S.T.R.E.T.C.H. (2018) | 0 | 0 |
| S.T.U.N. Runner (1989) | 124,163 | 145 |
| S.U.M. - Slay Uncool Monsters (2021) | 401 | 16 |
| S.W.I.N.E. (2001) | 4,785,449 | 585 |
| S2ENGINE HD (2016) | 16,730 | 70 |
| S4 League (2007) | 12,229,120 | 5,618 |
| S40 Racing (1997) | 5,940 | 4 |
| S4U: CITYPUNK 2011 AND LOVE PUNCH (2025) | 18,689 | 69 |
| Saban's Power Rangers Samurai (2011) | 2,409,659 | 180 |
| Sabbat of the Witch (2018) | 546,463 | 362 |
| Saber Ball (2023) | 0 | 0 |
| Saber Marionette J: Battle Sabers (1997) | 52,167 | 108 |
| Saber Ship (2022) | 106 | 1 |
| Sable (2021) | 25,246,526 | 5,241 |
| Sable Maze: Forbidden Garden (2014) | 34,654 | 105 |
| Sable Maze: Nightmare Shadows (2017) | 40,158 | 139 |
| Sable Maze: Norwich Caves (2013) | 21,432 | 71 |
| Sable Maze: Sinister Knowledge (2016) | 38,568 | 85 |
| Sable Maze: Soul Catcher (2015) | 45,166 | 100 |
| Sable Maze: Sullivan River (2012) | 43,423 | 86 |
| Sable Maze: Twelve Fears (2015) | 43,367 | 35 |
| Sable's Grimoire (2018) | 104,067 | 583 |
| Sable's Grimoire: A Dragon's Treasure (2020) | 8,120 | 176 |
| Sable's Grimoire: Man And Elf (2020) | 3,419 | 26 |
| Saborus (2025) | 35,304 | 2 |
| Sabotage (1981) | 100,856,924 | 1,463 |
| Sabotain: Break the Rules (2004) | 21,412 | 97 |
| Saboten Bombers (1992) | 24,185 | 68 |
| Saboteur (1985) | 400,346 | 198 |
| The Saboteur (2009) | 34,904,252 | 12,944 |
| Saboteur II: Avenging Angel (1987) | 98,010 | 107 |
| SABRE (2019) | 32,385,501 | 256 |
| Sabre Ace: Conflict Over Korea (1997) | 2,356 | 1 |
| Sabre Team (1992) | 26,348 | 51 |
| Sabre Wulf (1984) | 406,702 | 545 |
| Sabre Wulf (2004) | 252,623 | 224 |
| Sabres of Infinity (2016) | 2,663 | 19 |
| Sabrina the Teenage Witch: Potion Commotion (2002) | 11,786 | 23 |
| Sabrina, the Teenage Witch: Spellbound (1999) | 27,703 | 20 |
| Saccharine Pale (2023) | 4 | 2 |
| Sackboy's Prehistoric Moves (2010) | 193,096 | 66 |
| Sackboy: A Big Adventure (2020) | 79,759,899 | 44,683 |
| Sacra Terra: Angelic Night (2011) | 197,596 | 281 |
| Sacra Terra: Kiss of Death (2013) | 153,643 | 252 |
| Sacraboar (2009) | 566 | 7 |
| Sacre Bleu (2025) | 633,876 | 66 |
| Sacred (2004) | 8,638,076 | 8,266 |
| Sacred 2: Fallen Angel (2008) | 11,672,969 | 6,576 |
| Sacred 3 (2014) | 9,400,762 | 3,538 |
| The Sacred Acorn (2024) | 12,101 | 46 |
| Sacred Almanac: Traces of Greed (2016) | 70,354 | 56 |
| The Sacred Armour of Antiriad (1986) | 63,706 | 90 |
| Sacred Blaze (2009) | 43,146 | 60 |
| Sacred Citadel (2013) | 1,154,047 | 1,757 |
| Sacred Earth - Alternative (2023) | 518 | 8 |
| Sacred Earth - Promise (2018) | 12,360 | 58 |
| Sacred Earth - Reverie (2025) | 372 | 3 |
| Sacred Ember (2022) | 123 | 1 |
| Sacred Fire (2021) | 0 | 0 |
| Sacred Four (2018) | 1,649 | 8 |
| The Sacred Mirror of Kofun (1996) | 1,273 | 4 |
