| S H R i M P (2020) | 1,340 | 5 |
| S*M*A*S*H*E*D (1987) | 1,660,542 | 225 |
| S.A.I.A.'s Awakening: A Robothorium Visual Novel (2019) | 64 | 6 |
| S.C.A.R.S. (1998) | 21,992,159 | 580 |
| S.C.A.T.: Special Cybernetic Attack Team (1990) | 845,753 | 615 |
| S.C.OUT (1992) | 1,139,297 | 112 |
| S.D.I. (1986) | 25,643 | 25 |
| S.E.C.U. (2022) | 120,902 | 179 |
| S.L.A.I.: Steel Lancer Arena International (2005) | 8,811,341 | 407 |
| S.O.N (2019) | 10,707,662 | 83 |
| S.T.A.L.K.E.R. 2: Heart of Chernobyl (2024) | 791,087,943 | 157,789 |
| S.T.A.L.K.E.R.: Call of Pripyat (2009) | 862,239,558 | 116,733 |
| S.T.A.L.K.E.R.: Clear Sky (2008) | 325,610,890 | 42,686 |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (2007) | 849,902,942 | 132,447 |
| S.T.R.E.T.C.H. (2018) | 1,659,265 | 441 |
| S.T.U.N. Runner (1989) | 135,934 | 152 |
| S.U.M. - Slay Uncool Monsters (2021) | 401 | 16 |
| S.W.I.N.E. (2001) | 4,786,059 | 589 |
| S2ENGINE HD (2016) | 16,730 | 70 |
| S4 League (2007) | 12,371,170 | 5,721 |
| S40 Racing (1997) | 5,940 | 4 |
| S4U: CITYPUNK 2011 AND LOVE PUNCH (2025) | 18,716 | 70 |
| Saban's Power Rangers Samurai (2011) | 2,410,346 | 183 |
| Sabbat of the Witch (2018) | 559,260 | 435 |
| Saber Ball (2023) | 0 | 0 |
| Saber Marionette J: Battle Sabers (1997) | 52,309 | 109 |
| Saber Ship (2022) | 106 | 1 |
| Sable (2021) | 25,275,519 | 5,453 |
| Sable Maze: Forbidden Garden (2014) | 34,678 | 106 |
| Sable Maze: Nightmare Shadows (2017) | 40,158 | 139 |
| Sable Maze: Norwich Caves (2013) | 21,464 | 79 |
| Sable Maze: Sinister Knowledge (2016) | 38,568 | 85 |
| Sable Maze: Soul Catcher (2015) | 45,166 | 100 |
| Sable Maze: Sullivan River (2012) | 43,423 | 86 |
| Sable Maze: Twelve Fears (2015) | 43,367 | 35 |
| Sable's Grimoire (2018) | 105,174 | 605 |
| Sable's Grimoire: A Dragon's Treasure (2020) | 8,120 | 176 |
| Sable's Grimoire: Man And Elf (2020) | 3,682 | 43 |
| Saborus (2025) | 102,185 | 64 |
| Sabotage (1981) | 101,364,409 | 1,530 |
| Sabotain: Break the Rules (2004) | 21,463 | 99 |
| Saboten Bombers (1992) | 24,151 | 67 |
| Saboteur (1985) | 401,727 | 200 |
| The Saboteur (2009) | 36,390,066 | 13,548 |
| Saboteur II: Avenging Angel (1987) | 98,486 | 108 |
| SABRE (2019) | 33,116,982 | 262 |
| Sabre Ace: Conflict Over Korea (1997) | 2,356 | 1 |
| Sabre Team (1992) | 26,449 | 52 |
| Sabre Wulf (1984) | 410,032 | 559 |
| Sabre Wulf (2004) | 252,905 | 227 |
| Sabres of Infinity (2016) | 2,663 | 19 |
| Sabrina the Teenage Witch: Potion Commotion (2002) | 11,786 | 23 |
| Sabrina, the Teenage Witch: Spellbound (1999) | 27,703 | 20 |
| Saccharine Pale (2023) | 4 | 2 |
| Sackboy's Prehistoric Moves (2010) | 193,514 | 67 |
| Sackboy: A Big Adventure (2020) | 80,139,983 | 45,777 |
| Sacra Terra: Angelic Night (2011) | 197,682 | 298 |
| Sacra Terra: Kiss of Death (2013) | 153,647 | 253 |
| Sacraboar (2009) | 566 | 7 |
| SACRALITH: The Archer's Tale (2018) | 0 | 0 |
| Sacre Bleu (2025) | 633,950 | 68 |
| Sacred (2004) | 8,840,880 | 8,489 |
| Sacred 2: Fallen Angel (2008) | 12,629,555 | 7,594 |
| Sacred 3 (2014) | 9,404,314 | 3,570 |
| The Sacred Acorn (2024) | 12,101 | 46 |
| Sacred Almanac: Traces of Greed (2016) | 70,355 | 56 |
| The Sacred Armour of Antiriad (1986) | 63,895 | 92 |
| Sacred Blaze (2009) | 43,067 | 59 |
| Sacred Citadel (2013) | 1,155,331 | 1,772 |
| Sacred Earth - Alternative (2023) | 518 | 8 |
| Sacred Earth - Promise (2018) | 12,360 | 58 |
| Sacred Earth - Reverie (2025) | 2,674 | 31 |
| Sacred Ember (2022) | 123 | 1 |
| Sacred Fire (2021) | 1,437,361 | 221 |
| Sacred Four (2018) | 1,649 | 8 |
