| S H R i M P (2020) | 1,340 | 5 |
| S*M*A*S*H*E*D (1987) | 1,767,105 | 227 |
| S-Project 66 (2024) | 0 | 0 |
| S.A.I.A.'s Awakening: A Robothorium Visual Novel (2019) | 64 | 6 |
| S.C.A.R.S. (1998) | 21,997,019 | 584 |
| S.C.A.T.: Special Cybernetic Attack Team (1990) | 846,098 | 617 |
| S.C.OUT (1992) | 1,139,297 | 112 |
| S.D.I. (1986) | 25,643 | 25 |
| S.E.C.U. (2022) | 121,086 | 180 |
| S.L.A.I.: Steel Lancer Arena International (2005) | 8,827,307 | 411 |
| S.O.N (2019) | 10,707,662 | 83 |
| S.S.C. Rusted (2025) | 0 | 0 |
| S.T.A.L.K.E.R. 2: Heart of Chernobyl (2024) | 793,808,674 | 159,285 |
| S.T.A.L.K.E.R.: Call of Pripyat (2009) | 862,512,112 | 116,754 |
| S.T.A.L.K.E.R.: Clear Sky (2008) | 325,648,612 | 42,734 |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (2007) | 850,228,423 | 132,611 |
| S.T.R.E.T.C.H. (2018) | 1,661,536 | 441 |
| S.T.U.N. Runner (1989) | 135,934 | 152 |
| S.U.M. - Slay Uncool Monsters (2021) | 401 | 16 |
| S.W.I.N.E. (2001) | 4,786,093 | 589 |
| S2ENGINE HD (2016) | 16,730 | 70 |
| S4 League (2007) | 12,372,065 | 5,724 |
| S40 Racing (1997) | 5,940 | 4 |
| S4U: CITYPUNK 2011 AND LOVE PUNCH (2025) | 18,743 | 70 |
| Saban's Power Rangers Samurai (2011) | 2,410,346 | 183 |
| Sabbat of the Witch (2018) | 559,441 | 435 |
| Sabbatical In Merzouga (2025) | 0 | 0 |
| Saber Ball (2023) | 0 | 0 |
| Saber Marionette J: Battle Sabers (1997) | 52,348 | 111 |
| Saber Ship (2022) | 106 | 1 |
| Sable (2021) | 25,278,922 | 5,458 |
| Sable Maze: Forbidden Garden (2014) | 34,678 | 106 |
| Sable Maze: Nightmare Shadows (2017) | 40,158 | 139 |
| Sable Maze: Norwich Caves (2013) | 21,464 | 79 |
| Sable Maze: Sinister Knowledge (2016) | 38,568 | 85 |
| Sable Maze: Soul Catcher (2015) | 45,166 | 100 |
| Sable Maze: Sullivan River (2012) | 43,423 | 86 |
| Sable Maze: Twelve Fears (2015) | 43,367 | 35 |
| Sable's Grimoire (2018) | 105,195 | 605 |
| Sable's Grimoire: A Dragon's Treasure (2020) | 8,120 | 177 |
| Sable's Grimoire: Man And Elf (2020) | 3,684 | 44 |
| Saborus (2025) | 102,189 | 64 |
| Sabotage (1981) | 101,384,317 | 1,537 |
| Sabotain: Break the Rules (2004) | 21,463 | 99 |
| Saboten Bombers (1992) | 24,151 | 67 |
| Saboteur (1985) | 401,728 | 200 |
| The Saboteur (2009) | 36,617,082 | 13,658 |
| Saboteur II: Avenging Angel (1987) | 98,486 | 108 |
| SABRE (2019) | 33,118,260 | 264 |
| Sabre Ace: Conflict Over Korea (1997) | 2,356 | 1 |
| Sabre Team (1992) | 26,461 | 52 |
| Sabre Wulf (1984) | 410,133 | 559 |
| Sabre Wulf (2004) | 252,905 | 227 |
| Sabres of Infinity (2016) | 2,663 | 19 |
| Sabrina the Teenage Witch: Potion Commotion (2002) | 11,786 | 23 |
| Sabrina, the Teenage Witch: Spellbound (1999) | 27,703 | 20 |
| Saccharine Pale (2023) | 4 | 2 |
| Sackboy's Prehistoric Moves (2010) | 193,542 | 67 |
| Sackboy: A Big Adventure (2020) | 80,183,059 | 45,905 |
| Sacra Terra: Angelic Night (2011) | 197,689 | 299 |
| Sacra Terra: Kiss of Death (2013) | 153,647 | 253 |
| Sacraboar (2009) | 566 | 7 |
| SACRALITH: The Archer's Tale (2018) | 0 | 0 |
| Sacre Bleu (2025) | 633,962 | 69 |
| Sacred (2004) | 8,844,451 | 8,502 |
| Sacred 2: Fallen Angel (2008) | 12,656,075 | 7,670 |
| Sacred 3 (2014) | 9,404,519 | 3,571 |
| The Sacred Acorn (2024) | 12,101 | 46 |
| Sacred Almanac: Traces of Greed (2016) | 70,355 | 56 |
| The Sacred Armour of Antiriad (1986) | 63,895 | 92 |
| Sacred Blaze (2009) | 43,079 | 59 |
| Sacred Citadel (2013) | 1,156,719 | 1,774 |
| Sacred Earth - Alternative (2023) | 518 | 8 |
| Sacred Earth - Promise (2018) | 12,360 | 58 |
| Sacred Earth - Reverie (2025) | 2,674 | 31 |
