| Earth Defense Force 2 Portable (2011) | 753,457 | 168 |
| Earth Defense Force 2017 (2006) | 12,416,456 | 2,152 |
| Earth Defense Force 2017 (2012) | 280,044 | 231 |
| Earth Defense Force 2025 (2013) | 84,244,902 | 18,029 |
| Earth Defense Force 2: Invaders from Planet Space (2015) | 261,465 | 91 |
| EARTH DEFENSE FORCE 4.1 WINGDIVER THE SHOOTER (2018) | 0 | 0 |
| Earth Defense Force 4.1: The Shadow of New Despair (2015) | 33,753,356 | 10,443 |
| Earth Defense Force 4.1: Wingdiver the Shooter (2017) | 1,335,118 | 804 |
| Earth Defense Force 5 (2017) | 140,942,278 | 67,742 |
| EARTH DEFENSE FORCE 6 (2024) | 38,941,271 | 8,992 |
| Earth Defense Force: Insect Armageddon (2011) | 3,758,888 | 1,994 |
| Earth Defense Force: Iron Rain (2019) | 24,169,537 | 7,401 |
| EARTH DEFENSE FORCE: WORLD BROTHERS (2021) | 7,823,899 | 5,559 |
| EARTH DEFENSE FORCE: WORLD BROTHERS 2 (2024) | 32,420 | 103 |
| Earth Eternal (2009) | 358,742 | 61 |
| The Earth Fighter Rayieza (1985) | 36,296 | 98 |
| Earth Liberation (2016) | 145,457 | 40 |
| Earth Orbit Stations (1987) | 2,411 | 3 |
| EARTH SAVER (2025) | 0 | 0 |
| Earth Shaker (1990) | 690,851 | 148 |
| Earth Space Colonies (2016) | 332,406 | 87 |
| Earth Space Defenders (2025) | 0 | 0 |
| Earth's Center of Gravity (2022) | 1,234 | 4 |
| Earth's Dawn (2015) | 702,700 | 805 |
| Earth's Greatest Defender (2023) | 554 | 7 |
| Earth's Shadow (2022) | 241,422 | 414 |
| Earth: 9000 (2020) | 3 | 1 |
| Earthbound (1994) | 313,696,348 | 88,694 |
| Earthfall (2017) | 25,686,774 | 3,450 |
| Earthlight (1988) | 18,454 | 21 |
| Earthling of Gaia (2024) | 203 | 3 |
| Earthlock (2016) | 6,549,551 | 3,230 |
| Earthlock 2 (2022) | 32,651 | 33 |
| Earthly Delights (1984) | 59,143 | 17 |
| EarthNight (2019) | 1,331,408 | 340 |
| Earthquake: Margarita School (2024) | 31,852 | 14 |
| Earthrise (1990) | 529 | 5 |
| Earthrise (2011) | 109,276 | 9 |
| EarthRoyale (2022) | 3,531,015 | 110 |
| Earthshine (2019) | 373,696 | 42 |
| Earthsiege 2 (1995) | 108,454 | 119 |
| Earthtongue (2015) | 12,272 | 19 |
| Earthworm Jim (1994) | 36,079,646 | 8,082 |
| Earthworm Jim 2 (1995) | 12,436,908 | 3,607 |
| Earthworm Jim 3D (1999) | 3,330,199 | 737 |
| Earthworm Jim HD (2010) | 1,389,290 | 739 |
| Earthworm Jim: Menace 2 the Galaxy (1999) | 522,708 | 131 |
| Earthworms (2018) | 7,458,494 | 320 |
| East India Company (2009) | 2,325,560 | 281 |
| East Side Story - The 4th Carol Reed Mystery (2007) | 17,843 | 83 |
| East Trade Tycoon: Inheritance (2024) | 10,557 | 37 |
| East vs. West: Berlin 1948 (1989) | 4,055 | 5 |
| East Wind (2025) | 73,697 | 114 |
| Eastenders (1987) | 2,868,742 | 362 |
| Easter Bonus (2006) | 150 | 8 |
| Easter Candy Break (2021) | 9,467 | 57 |
| The Eastern Drive : Car Simulator (2023) | 112 | 2 |
| Eastern Exorcist (2020) | 1,297,760 | 2,311 |
| Eastern Mind: The Lost Souls of Tong Nou (1994) | 1,390,704 | 113 |
| Eastshade (2019) | 4,429,508 | 3,584 |
| Eastside Hockey Manager (2015) | 687,028 | 543 |
| Eastward (2021) | 14,280,025 | 14,317 |
| Eastward Legend: The Empyrean (2019) | 6,447 | 8 |
| Eastwind Adventures: Chapter 1 (2025) | 0 | 0 |
| Eastwynne (2026) | 24 | 1 |
| Easy Bubbles (2025) | 0 | 0 |
| Easy Bug Manager (2020) | 0 | 0 |
| Easy Delivery Co. (2025) | 19,790 | 56 |
| Easy Flight Simulator (2021) | 46,469 | 25 |
| Easy Game Creator (2022) | 40 | 1 |
| Easy Hentai (2019) | 0 | 0 |
| Easy hentai puzzle (2019) | 0 | 0 |
| Easy hentai puzzle 2 (2019) | 0 | 0 |
| Easy Japanese Hiragana (2024) | 0 | 0 |
| Easy Joe (2010) | 197,978 | 47 |
