| 1. |  The Spiffing Brit | Plague Inc Is A Perfectly Balanced Game With No Exploits - Unlock All Genes Instantly | 4,443 | |
| 2. | TrippyPepper | So I Hacked Plague Inc & infected billions of people in minutes... (MAX DISEASE) | 2,453 | |
| 3. | HybridPanda | LET'S KILL EVERYONE!! Plague Inc. Evolved | 2,414 | |
| 4. | HybridPanda | Damn it Canada! - Plague Inc. Evolved with Panda #6 | 2,200 | |
| 5. | HybridPanda | We Need Master Chief! - Plague Inc. Evolved #5 | 2,137 | |
| 6. | HybridPanda | Cthulu Rises! - Plague Inc. Evolved #4 | 1,840 | |
| 7. | HybridPanda | Panda-Flu Arrives! - Plague Inc. Evolved #2 | 1,806 | |
| 8. | HybridPanda | CURLY FRIES OF DOOM - Plague Inc Evolved with YOGSCAST Panda | 1,775 | |
| 9. | HybridPanda | Butt Shrooms! - Plague Inc. Evolved #3 | 1,762 | |
| 10. | Vikkstar123 | VIKS SWAG vs ZERKOLA - PLAGUE INC | 1,647 | |
| 11. | Vikkstar123 | THE TRUMP VIRUS - PLAGUE INC | 1,619 | |
| 12. | The Yogscast | WATCH THE WORLD BURN - Plague Inc. | 1,328 | |
| 13. | 8-BitGaming | The Killer Virus.. || Plague Inc | 1,295 | |
| 14. | HybridPanda | Slugs In Your Brain! - Plague Inc. Evolved with Panda #7 | 1,283 | |
| 15. | The Mighty Jingles | Steam Summer Sale - Plague Inc. | 943 | |
| 16. | Vikkstar123 | KILLING THE WHOLE WORLD - PLAGUE INC | 881 | |
| 17. | Syndicate | REBECCA BLACK's RETURN! (Plague Inc) | 778 | |
| 18. | The Mighty Jingles | Plague Inc - Braaaaaains! | 724 | |
| 19. | The Mighty Jingles | Plague Inc - No News Like Fake News | 671 | |
| 20. | Real Civil Engineer | This is humanity's biggest threat... | 587 | |
| 21. | Duncan | Plague Inc - Multiplayer - DANK MEMES VS SJINGLES | 534 | |
| 22. | HybridPanda | CATS, CATS EVERYWHERE! Plague Inc with Panda! [Cat-a-Strophe] | 523 | |
| 23. | HybridPanda | STAMPEDE!!!!! Plague Inc with Panda [Black Death] | 460 | |
| 24. | HybridPanda | Banana Madness! #20 - Plague Inc. Evolved [Simian Flu - Brutal] | 459 | |
| 25. | HybridPanda | Plague Inc. 60 FPS #39 - Rise of the Xenomorph with Yogscast Panda | 396 | |
| 26. | HybridPanda | RELEASE THE APES! Simian Flu - Plague Inc UPDATE! :D | 376 | |
| 27. | 8-BitGaming | HA! GAT EEEEM! || Plague inc. | 357 | |
| 28. | Arkstone | Plague inc World Record Speedrun (Necroa Virus Mega Brutal) Time 4:55 | 357 | |
| 29. | HybridPanda | Return of the Worms! - Plague Inc. with Panda | 343 | |
| 30. | caramida9 | MY ZOMBIE APOCALYPSE! Let's play Plague Inc on PC:Necroa virus | 329 | Let's Play |
| 31. | HybridPanda | Plague Inc. 60 FPS #40 - The Last Of Us with Yogscast Panda | 320 | |
| 32. | The Wandering Inn | Plague Inc. Evolved - Neurax Worm Normal Walkthrough | 307 | Walkthrough |
| 33. | HybridPanda | Monkey Spanking #22 Plague Inc with Panda [Simian Flu Brutal] | 300 | |
| 34. | HybridPanda | Plague Inc Gameplay Part 30 - Dino Portals! with Yogscast Panda | 278 | |
| 35. | The Wandering Inn | Plague Inc. Evolved - Nano-Virus Normal Walkthrough | 247 | Walkthrough |
| 36. | The Wandering Inn | Plague Inc. Evolved - Bio Weapon Brutal Walkthrough | 247 | Walkthrough |
| 37. | HybridPanda | Plague Inc. Gameplay Part 32 - FUN SUCKS with Yogscast Panda | 224 | |
| 38. | HybridPanda | Plague Inc. Gameplay #35 - The Thinggg! with Yogscast Panda | 220 | |
| 39. | BestInSlot | Plague Inc Custom Scenario: Jurassic Planet | MY OWN CUSTOM DINOSAUR SCENARIO! | 196 | |
| 40. | BestInSlot | Plague Inc Custom Scenario : Rise Of The Xenomorphs | THE ALIEN XENOMORPH PLAGUE | 175 | |
| 41. | BestInSlot | Plague Inc Custom Scenario: Beyond Human | CAN HUMANITY EVOLVE FURTHER? | 165 | |
| 42. | Mr Williamo | JOHN CENA TAKES OVER THE WORLD! | Plague Inc. Evolved | 150 | |
| 43. | dani pinkman | ویروسی که از ایران شروع شد و قراره کل موجودات روی کره زمین رو از ببره! | 149 | |
| 44. | HybridPanda | Plague Inc. Gameplay Part 34 - Necrosis Burgers with Yogscast Panda | 143 | |
| 45. | The Wandering Inn | Chickens! Shrek & Markiplier (Plague Inc Evolved Customs) | 142 | Walkthrough |
| 46. | HybridPanda | Plague Inc Gameplay Part 33 - Winged Blobs! with Yogscast Panda | 131 | |
| 47. | caramida9 | I WILL CONTROL YOUR BRAIN! Let's play Plague inc on PC:Neurax worm | 130 | Let's Play |
| 48. | Aavak | First Taste of... Plague Inc. Evolved | 125 | |
| 49. | The Wandering Inn | Sheep's Subscriber Special - Plague Inc Evolved |All Plagues - Mega Brutal| | 119 | Walkthrough |
| 50. | caramida9 | TIME TO KILL THE WORLD! Let's play Plague Inc on PC | 117 | Let's Play |
| 51. | Mr Williamo | LOVE IS IN THE AIR!! | Plague Inc. Evolved | 107 | |
| 52. | BestInSlot | Plague Inc Custom Scenario: Rise Of Dragons | REIGN OF FIRE | 105 | |
| 53. | HybridPanda | Plague Inc. 60 FPS #36 - The Thinggg Returns! with Yogscast Panda | 99 | |
| 54. | BestInSlot | Plague Inc Custom Scenario : Rise Of The Insects | CAN INSECTS TAKE OVER THE WORLD? | 98 | |
| 55. | BestInSlot | Plague Inc Custom Scenario: Cult Of Cthulhu | RAISE THE OLD GODS! | 98 | |
| 56. | BestInSlot | Plague Inc Custom Scenario: Dinosaur Plagues! | RISE OF THE DINOSAURS | 88 | |
| 57. | Joe Chip | Plague Inc. and the Anti Vaxxer Epidemic | 86 | |
| 58. | BestInSlot | Plague Inc: Shadow Plague | STUPID SEXY VAMPIRES | 86 | |
| 59. | HybridPanda | Plague Inc. Gameplay #37 - Scumbag Thing, Also Zombies with Yogscast Panda | 84 | |
| 60. | Mr Williamo | MY GRANDMA CREATES A PLANET OF THE APES! | Plague Inc. Evolved | 80 | |
| 61. | Evildoerz | CUTEST PLAGUE! - Pip & Twitch - Plague Inc: Evolved | 79 | |
| 62. | The Wandering Inn | Plague Inc Evolved Scenario - Artificial Organs | 76 | Walkthrough |
| 63. | Dead Inside Gaming | Ruining 8,018,277,964 lives with Cats - Plague Inc. Evolved | 74 | |
| 64. | BestInSlot | Plague Inc Custom Scenario: SCP-751 ORGAN EATER | A DISEASE THAT EATS YOUR ORGANS! | 73 | |
| 65. | HybridPanda | Plague Inc. Evolved | New YouTube | #68 | 71 | |
| 66. | Alirexza | کرونا استریم | 69 | |
| 67. | The Wandering Inn | Plague Inc. Evolved - Virus Brutal Walkthrough | 68 | Walkthrough |
| 68. | The Wandering Inn | Plague Inc. Evolved - Bacteria Brutal Walkthrough | 61 | Walkthrough |
| 69. | The Wandering Inn | Plague Inc Evolved Scenario - The Black Death | 55 | Walkthrough |
| 70. | caramida9 | NOT ANOTHER ZOMBIE GAME! Let's play Plague inc on PC | 53 | Let's Play |
| 71. | Dead Inside Gaming | Ending 8 Billion Lives With Poop in Plague Inc. Evolved | 53 | |
| 72. | The Wandering Inn | Plague Inc. Evolved - Prion Brutal Walkthrough | 51 | Walkthrough |
| 73. | BestInSlot | Plague Inc Custom Scenario: Pokémon GO | WILL POKEMON DESTROY US ALL? | 49 | |
| 74. | HybridPanda | Burger Time! Puppy, DayZ, Ladyboys, Plague Inc, Isaac, and more! | 49 | |
| 75. | TripleJump | TripleJump Podcast #50: Plague Inc. - Coronavirus Causes Sales Surge? | 49 | Show |
| 76. | Patterrz | How Pokemon will Destroy the World | 47 | |
| 77. | Dead Inside Gaming | When Life Gives You Lemons, Make THE APOCALYPSE. | 46 | |
| 78. | Stuff+ | iPlague = Beverage + Plague Inc: Evolved [Early Access] | 46 | |
| 79. | Arcadam | NEW PLAGUE WILL WIPE US ALL OUT! | 44 | |
| 80. | HybridPanda | Plague Inc. Evolved Shadow Plague | YouTube KILLS | #71 | 41 | |
| 81. | ParkyGames | Plague Inc. (Bacteria) - Part 1 - Let's Destroy the World | 41 | Let's Play |
| 82. | ParkyGames | Plague Inc. (Neurax Worm) - Part 5 - Extreme BO | 36 | Let's Play |
| 83. | The Wandering Inn | Corpus Plague - Gruesome Deaths! (Plague Inc Evolved Customs) | 33 | Walkthrough |
| 84. | Sinstar | I wiped out EVERYONE with a deadly virus in 6 minutes. (Pandemic 2 Speedrun World Record) | 32 | |
| 85. | benjaminh428 | The Almighty Stench - Plague Inc. Evolved Xbox One Part 1 | 31 | |
| 86. | caramida9 | PLAY ALL THE SCENARIOS! Let's play Plague Inc 1.7 on PC | 31 | Let's Play |
| 87. | Jay Exci | Playing Plague Inc without mentioning the coronavirus | 31 | |
| 88. | Edit:Ed | PLAGUE INC. EVOLVED MULTIPLAYER: (ONE-OFF) - INABILITY TO TWERK WILL CRIPPLE HUMANITY | 30 | Let's Play |
| 89. | The Wandering Inn | Plague Inc. Evolved Co-op /w Peachy #1 | 28 | Walkthrough |
| 90. | ParkyGames | Plague Inc. (Prion) - Part 7 - Stupidity. | 27 | Let's Play |
| 91. | The Wandering Inn | Plague Inc Evolved Scenario - Nipah Virus | 26 | Walkthrough |
| 92. | caramida9 | THE SWINE FLU! Let's play Plague Inc 1.7 on PC | 26 | Let's Play |
| 93. | Nymbal | How To Get All Plague Inc. DLC for FREE! - Tutorial | 25 | Tutorial |
| 94. | caramida9 | The Simian Flu! Let's play Plague Inc: Mutation 9 (Blind run) | 24 | Let's Play |
| 95. | ColloseusX | Plague Inc - Bacteria Completion! | 24 | |
| 96. | ParkyGames | Plague Inc. (Simian Flu Virus) - Part 3 - Batman's Abs | 22 | Let's Play |
| 97. | benjaminh428 | The Trojan Goat Virus - Plague Inc. Evolved Xbox One Part 2 | 21 | |
| 98. | Arkstone | Plague Inc Necroa virus mega brutal no genes | 20 | |
| 99. | The Wandering Inn | Plague Inc Evolved - I Will Play Your Custom Scenarios | 20 | Walkthrough |
| 100. | caramida9 | APES RULE! Let's play Plague Inc Mutation 9 Brutal Guide | 20 | Let's Play |
