| 1. |  Duncan | 2,274,571 | Sanctum 2 - Outpost (Part 2) [Feat. Sjin] | 18:24 |
| 2. |  Coffee Stain Studios | 953,914 | Sanctum 2 DLC4 Official Release Trailer - The Last Stand | 1:24 |
| 3. |  CaptainSparklez | 708,471 | Sanctum 2 w/ Nick: Not Love | 25:20 |
| 4. | The Yogscast | 690,749 | Sanctum 2 - Maze Making 2.0 | 15:26 |
| 5. | SgtRumpel | 306,630 | Sanctum 2 #029 - Gegen den Strom [FINALE] [FullHD] [deutsch] | 28:36 |
| 6. | YotobiGames | 249,642 | HUMBLE BUNDLE DAY - Sanctum 2 e Manos, The Hands Of Fate | 10:20 |
| 7. |  YouAlwaysWin | 240,721 | Construction Site: Sanctum 2 | Dumb and Dumber | 27:31 |
| 8. | BFChickenGamers | 224,431 | Sanctum 2 | Bölüm 5 | Yeni kuleler. | 28:27 |
| 9. |  KUN | 187,101 | 【Sanctum2】火力で押し切る田中とKUN【KUN】 | 10:02 |
| 10. |  LetsPlayPoRusski | 168,371 | Cтрим c Хагом и Синксом (6 сентября 2014) 1/2 | 59:59 |
| 11. | ニート部 | 157,246 | 最強難易度のタワーディフェンスゲームを４人で打破します - Sanctum 2 | 27:29 |
| 12. | Smosh Games | 140,952 | SANCTUM 2 REVIEW | 3:40 |
| 13. | GhostRobo | 126,801 | SHOOT THE BUTT!! - Sanctum 2 Gameplay (Sanctum 2 Part 2 - Co-Op Multiplayer) | 21:22 |
| 14. | WolfsGoRawr | 125,485 | Sanctum 2: Awesome Patch! (Thoughts) | 6:27 |
| 15. | GameSpot | 114,552 | Sanctum 2 - Live Action Launch Trailer | 1:32 |
| 16. |  pingvinharcos | 104,033 | Tower Defense hetek - Sanctum 2 - 3. rész | 20:28 |
| 17. |  Action Tadka India | 88,504 | Inner Sanctum II - इनर सैक्टम - Full Length Thriller Hindi Movie | 1:19:50 |
| 18. |  Skyyart | 87,673 | ♠[COOP] Le BOSS Qui a 0 Respect ! ♦ Skyyart Sanctum 2 #2 | 28:34 |
| 19. | kootra | 84,985 | Sanctum 2 Meowing Ep. 8 | 12:41 |
| 20. |  Samed Güngör | 77,920 | BURALARIN DEFANSI BENDEN SORULUR / Sanctum 2 : Türkçe Multiplayer Oynanış | 31:17 |
| 21. | STAMSITE | 73,278 | Rocky Fields! - Sanctum 2 #6 (Swedish) | 36:17 |
| 22. | IGN | 63,792 | Sanctum 2 - The Last Stand Release Trailer | 1:24 |
| 23. | Minoru Leo: No Commentary Gaming | 59,497 | Sanctum 2 {***NO DLC***} [Part 8] (Skye) Train Station (5 Feats of Strength / Solo) | 23:06 |
| 24. | LarfinMan | 53,819 | Sanctum 2 - The Last Stand (DLC) Easter Eggs | 1:24 |
| 25. | Oktoberbot | 52,961 | Sanctum 2 Soundtrack - Defeat Theme | 2:19 |
| 26. | DualDGaming | 48,988 | DualD Gaming Spelar Sanctum 2 - Del 2 | 32:34 |
| 27. | Blitzwinger | 48,953 | Sanctum 2 - Part 3 - Flying Things Bugs (Gameplay & Commentary) | 25:16 |
| 28. | Akabane101 | 47,059 | Sanctum 2 Co-op Gameplay - Ep.4: Death Island | 24:02 |
| 29. |  Wedry | 45,608 | Wedry hraje Sanctum - Ep. 2 - Jsem špatnej :( (+Soutěž!) | 48:46 |
| 30. | Classic Game Room | 42,834 | Classic Game Room - SANCTUM 2 review | 6:54 |
| 31. | CaptainLance9 | 40,223 | Sanctum 2.0 Walkthrough | 21:12 |
| 32. |  PokeR988TV | 38,907 | Sanctum 2 con Poxe y Psicotic! A por los cabezabolos! | 59:06 |
| 33. | Игромания | 37,287 | Во что поиграть на этой неделе? - 17 мая 2013 (Метро 2033: Луч Надежды, Dust 514, Sanctum 2) | 11:21 |
| 34. | locopuyo | 36,199 | The Last Stand - Sanctum 2 Campaign - Wave 18 | 1:09:43 |
| 35. |  Kingx Ray | 35,155 | Sanctum 2: Map glitching in "Outpost" (Part 2) | 3:35 |
| 36. |  Hi,I'm 5 | 33,665 | 秋風回覆您留言 - 2014年第十八週 | 8:21 |
| 37. | ダステル - DustelBox | 32,677 | 【実況】襲い来るエイリアンから 貞操を守り抜け！【Sanctum】 | 14:46 |
| 38. | Northernlion | 30,013 | Northernlion is streaming soon! | 1:18 |
| 39. | Csúb - Az Űrmedve | 29,819 | Gémbot | Dark Souls 2 végigjátszás 24. rész : Cave of the Dead & Dragon's Sanctum (2/2) | 21:19 |
| 40. | Zdochliakk | 24,462 | ► Sanctum 2 - Invázia sa začala | #1 | w/Thomas /Gogo | Slovenský - Český Gameplay | 32:39 |
| 41. | sophycz | 24,419 | Sanctum [Sophy.cz] | 29:04 |
| 42. | Dan Field | 23,904 | Fortified - Un tower défense "à la" Sanctum 2 et Orcs Must Die 2 ! || P&G [FR] | 29:10 |
| 43. | Szefistudio | 21,788 | Sanctum 2 játszás! | 35:23 |
| 44. | Dozkoz | 20,856 | Обзорчик на Sanctum | 41:44 |
| 45. | Trolltest de | 19,358 | Sanctum 2 - TLDW (Kurz-Video) | 3:45 |
| 46. | MoiCoopToi SvenGaerus | 18,825 | Sanctum 2 - FR CoOp Gameplay [MoiCoopToi] | 30:40 |
| 47. | Thomasova Videa | 18,197 | Sanctum 2 - |#2| - S bossem na jazykové lekci! | Český Gameplay | w/ Zdochliakk | 26:07 |
| 48. | Giant Bomb | 16,060 | Sanctum 2: Giant Bomb Quick Look EX | 25:01 |
| 49. | SpartecusNL | 15,686 | sanctum 2 - part 10: Xbox One Porn | 16:24 |
| 50. | Project Phoenix Media | 15,281 | [How To] Play Sanctum 2 With PC or PS2 USB Controller Tutorial | 4:16 |
| 51. | Hihu | 15,058 | Sanctum 2 - Review | 7:21 |
| 52. | TeamxEggS | 14,697 | Sanctum 2 | Let's Play | Finale | Part 41 | w/ Sweet, Gangsta & Tunkum | 18:20 |
| 53. |  ThePlaygamerBr | 14,669 | FIM PRA SEMPRE DO ONLINE E DEMISSÕES / JOGO 100% GRATUITO NO PC | 5:16 |
| 54. | CGRundertow | 14,248 | CGR Undertow - SANCTUM 2 review for Xbox 360 | 4:41 |
| 55. | Leviathyn | 14,111 | Chamber of Game: Sanctum 2 DLC: The Last Stand | 42:36 |
| 56. | Dyshnila | 14,049 | Sanctum 2 | ДИКАЯ НАРКОМАНИЯ [#2] [20-00МСК] | 2:05:57 |
| 57. | ZellenDust | 13,499 | SANCTUM 2 - PRIMERAS IMPRESIONES (Review/gameplay HD comentado español) | 16:52 |
| 58. | TheFaceGame | 13,065 | Taylor VS Mostri Insulsi !! | 8:15 |
| 59. | HDPLAY Gaming TV | 12,629 | Sanctum 2 Walkthrough - PART 10 | Roadworks (Commentary) | 33:35 |
| 60. | IGM | 11,799 | Sanctum 2 - Дрочуны | 18:42 |
| 61. | Kon-Troll | 11,694 | ÓRIÁS MAROK | Sanctum 2 | 3:23 |
| 62. | Игро День | 11,618 | 🎮УСПЕЙ СКАЧАТЬ | КРУТОЙ ШУТЕР SANCTUM 2 БЕСПЛАТНО! | 1:36 |
| 63. | Kwantonium | 11,180 | LET'S PLAY: Sanctum Part 2 | 29:43 |
| 64. | Gryff-User Gaming | 11,029 | Return to Sanctum Episode 1 Gryff User Back In Action | 30:05 |
| 65. | Hisao Wada | 10,915 | Sanctum 2 Gameplay | 8:01 |
| 66. | 白夜 零兎 / Shiroya Reito | 10,914 | 【Sanctum2】このゲームおもしろくない？【白夜零兎/四宮伊織/藍月すりっぷ】 | 1:55:29 |
| 67. | Stuff+ | 10,913 | Beverage + Sanctum 2 | 32:53 |
| 68. | angelysaras | 10,841 | GRATIS SANCTUM 2 EN PC | 1:11 |
| 69. | DeadHerrings | 10,145 | The Sanctum 2 Tower Files: Gatling Tower | 1:35 |
| 70. | golffreak246 | 9,526 | Let's Play Sanctum 2 w/Friends Part 32 | 15:39 |
| 71. | MisterebriO | 9,393 | SANCTUM | A juegar! | 20:32 |
| 72. |  Алекс rempc by | 9,301 | Халява #35 (23.11.17). Sanctum 2 бесплатно успей забрать | 3:28 |
| 73. |  Full Burazeri | 9,250 | Gaming Sou Subota - Sanctum 2 | 19:43 |
| 74. | Rails2Revolution | 9,105 | VLOG // Aannnddd We're Back! | 5:56 |
| 75. | o0changoboyGT0o | 8,990 | Sanctum 2 - Como Jugar COOP ONLINE !! | 2:00 |
| 76. | FyreUK [ARCHIVE] | 8,784 | Matt and Phil Play - Sanctum 2 : Part 1 | 14:46 |
| 77. | Яков Свиридов | 8,634 | PerfectNoob - обзор Sanctum 2 | 9:56 |
| 78. | NecrosVideos | 8,496 | Garry's Mod: Sanctum 2 Weapons Mod Showcase | 13:00 |
| 79. | MackandMesh | 8,219 | Sanctum Playthrough (Indie Month!) - Part 3 | 16:16 |
| 80. |  Ronald | 8,144 | RONALD,BJORN EN JEROEN VS. ALIENS! ( Deel 1 ) | 18:39 |
| 81. |  ariodb | 7,473 | Sanctum 2 Gameplay [ITA] | 18:01 |
| 82. | LixianVG | 7,424 | CHAOS AT IT'S BEST - Loadout | Ep.1 w/ Samus Worth | 8:24 |
| 83. | Неоф.Канал Рецензии Игромании | 7,416 | Sanctum 2 - рецензия Игромании | 8:56 |
| 84. |  VisualGamerTH | 7,413 | 5 เกม Steam สเปคต่ำ! คอมไม่แรงก็เล่นได้ EP.01 | 8:01 |
| 85. | MrRokwar | 7,301 | sanctum27 | 22:15 |
| 86. | VGFAQ | 7,282 | Sanctum 2 Xbox 360 Gameplay Trailer | 6:48 |
| 87. | AliveinGamesTV | 7,078 | Sanctum 2 İlk Bakış AliveinGames | 11:14 |
| 88. | dlive22891 | 7,024 | Sanctum 2 W/ Minx, Krism & Ziegs (2) WRECKING ENEMIES [STREAM] | 18:11 |
| 89. | 昭柴猫的猫老师 | 7,006 | 10款Steam上好玩的多人聯機塔防獨立遊戲推薦-Tower Defence 003 | 8:01 |
| 90. | GamesRadar | 6,989 | Sanctum 2 Developer Demo | 10:57 |
| 91. |  theultramage | 6,661 | Sanctum 2 - 6-4: SOKOL, all 5 FoS, solo, 100% healed core | 27:37 |
| 92. | PsychoWolf20 | 6,645 | Sanctum 2 Gameplay - Tower Defense FPS Style | 10:00 |
| 93. |  GameNewsNetwork | CS:GO Matches & Highlights Daily | 6,543 | Sanctum 2 Gameplay HD PC (Review) | 5:39 |
| 94. | Fallen Angels | 6,097 | Sanctum 2: Dancing Lama Easteregg | 0:00 |
| 95. | Atratzu | 5,830 | My Thoughts on Sanctum 2 | 30:56 |
| 96. |  MrAntiFun | 5,759 | Sanctum 2 Road to Elysion update #5 DLC Trainer +4 MrAntiFun | 0:55 |
| 97. | Hermanos de Sake | 5,682 | Sanctum 2 - GRATIS por tiempo limitado jajá | 30:39 |
| 98. | CoinOpTV | 5,614 | Sanctum 2 Official Launch Trailer | 1:18 |
| 99. | Иван Лоев | 5,540 | [ТРИ-В-ОДНОМ] Sanctum 2. Бум дагассар, разбей хабибальбоссар! | 4:22:05 |
| 100. | Shodredux | 5,414 | Sanctum 2 Tutorial: The Basics | 4:28 |
