| 1. |  DangerouslyFunny | I Forced This Creature To Evolve Into Spikes in Sipho | 549,348 | |
| 2. |  Blitz | Evolving a Battle Creature in Sipho! | 422,676 | |
| 3. |  CRYSTAL | ЭВОЛЮЦИЯ ПОЖИРАТЕЛЯ ЧТОБЫ ИЗ КОЗЯВКИ СТАТЬ ГИГАНТОМ В ИГРЕ SIPHO! | 310,132 | |
| 4. | Blitz | Evolving the Ultimate Crab Monster! - Sipho Gameplay | 307,292 | |
| 5. | Fady | WHICH OVERPOWERED HIGHEST DNA BOSS IS STRONGER? (9999+ DAMAGE LEVEL) l Sipho.io Update | 253,887 | Vlog |
| 6. |  Fynnpire | BUILD AN ALIEN TO EAT OTHER ALIENS! - Sipho Gameplay - IO & Spore style game | 157,467 | |
| 7. |  perpetuumworld | РАЗВИТИЕ ОРГАНИЗМА ПОД МИКРОСКОПОМ ( Sipho ) | 151,873 | |
| 8. | Drae | Evolving to Dominate Entire Ecosystems in Sipho | 120,294 | |
| 9. | CRYSTAL | ОТ МИКРОБА ДО ХИЩНИКА! - Sipho | 117,044 | |
| 10. | Blitz | I EVOLVED The Most DANGEROUS Creature in SIPHO | 105,869 | |
| 11. | Fynnpire | GIANT BUG ALIEN FIRES SPIKES AT ENEMIES! - Sipho Gameplay - IO & Spore style game | 102,359 | |
| 12. | Fady | HOW STRONG IS MOST OVERPOWERED CREATURE BOSS EVOLUTION? (9999+ DNA LEVEL) l Sipho.io New .IO Games | 99,948 | |
| 13. | perpetuumworld | СОЗДАЛИ ОРГАНИЗМ ПИЯВКУ ( Sipho ) | 95,883 | |
| 14. | Fady | IS THIS THE STRONGEST HIGHEST LEVEL CREATURE BOSS LEVEL? (9999+ DNA EVOLUTION) l Sipho.io Update | 79,679 | Vlog |
| 15. | Lathland | What If Spore's Cell Stage Was A Roguelike? | 69,810 | |
| 16. | CRYSTAL | ЭВОЛЮЦИЯ ПОЖИРАТЕЛЯ ЧТОБЫ КОЗЯВКА ВСЕХ СОЖРАЛА В ИГРЕ SIPHO! | 68,887 | |
| 17. | Drae | I Built an Organism that Destroys Entire Ecosystems in Sipho | 57,280 | |
| 18. | Wanderbots | Surprisingly Deep Spore Cell Stage Roguelike! - Sipho [Full Release] | 54,719 | |
| 19. | perpetuumworld | Создаем свой организм ! ( Sipho ) | 39,530 | |
| 20. | InterndotGif | Evolving The MOST DEADLY Organism in Sipho | 37,940 | |
| 21. | ScrapMan | SIPHO - Spore Meets Nimbatus? - Sipho Gameplay First Look | 36,260 | First Impressions |
| 22. | Fynnpire | DEADLY ALIEN WITH 4 CLAWS! - Sipho Gameplay - IO & Spore style game | 30,637 | |
| 23. | Splattercatgaming | Growing to Feed And Destroy Hostile Creatures! - Sipho Gameplay Impressions | 29,360 | |
| 24. | ScrapMan | Trying New Weapons! - Sipho Gameplay Ep2 | 29,308 | |
| 25. | InterndotGif | Using EXPLOSIVE WHIRLPOOLS To Destroy The Ecosystem in Sipho | 27,385 | Let's Play |
| 26. | Wanderbots | Let's Play Sipho - PC Gameplay Part 1 - I Am The Battle Craff! | 21,709 | Let's Play |
| 27. | Muzzloff Play | Первая Стадия SPORE Стала Отдельной Игрой - SIPHO | 16,710 | |
| 28. | Nookrium | Sipho - (Spore-Like Creature Evolution Sandbox Game) | 16,567 | |
| 29. |  JoshFTL | BUILD THE ULTIMATE ALIEN PREDATOR - Sipho | 16,023 | |
| 30. |  Dan Field | Sipho [FR] Evoluez et survivez à la soupe primordiale! Gameplay à la Spore! | 13,629 | |
| 31. | Ramaros | SPORE EN MODE ROGUELIKE!!! (Sipho) | 10,464 | |
| 32. | Стримы Интроверта | Споровый РОГАЛИК - Sipho - Первый взгляд | 10,417 | |
| 33. | Wanderbots | Let's Play Sipho - PC Gameplay Part 2 - Lean & Not So Mean | 9,756 | Let's Play |
| 34. | Aavak | Engineering an Alien Organism to Destabilise the Ecosystem in Sipho! | 8,485 | Let's Play |
| 35. | Ramaros | ON TENTE LE BOSS AU CORPS À CORPS ! (Sipho) | 8,444 | |
| 36. | Nookrium | Fciv.net - (Free Civilization Building Strategy Game) | 8,250 | |
| 37. | INDIE | Sipho | Сын Spore и Reassembly | 8,197 | |
| 38. | ReformistTM | Sipho Gameplay Let's Play PC Part 1 (EVOLVE TO SURVIVE) | 8,112 | Let's Play |
| 39. | KatherineOfSky | Sipho Ep 1: BUILDING KILLER MICROBES! - First Look/Press Preview - Let's Play, Gameplay | 8,078 | Let's Play |
| 40. | DarkEdgeTV | SIPHO #3 - Beefy Snappy Zooid | 7,651 | |
| 41. | El Escoces gamer | En serio, este "SPORE" es un VICIO - Sipho Gameplay Español | 7,161 | |
| 42. | DarkEdgeTV | SIPHO - Testing (and Breaking) The New Aquarium! | 3,603 | |
| 43. | Стримы Интроверта | Ах, вот как играть - Sipho #2 | 3,409 | |
| 44. | KatherineOfSky | Sipho Ep 2: CLAWS OF DRIPPING DEATH - First Look/Press Preview - Let's Play, Gameplay | 3,406 | Let's Play |
| 45. | Стримы Интроверта | ФИНАЛ (можно сказать) - Sipho #4 | 2,837 | |
| 46. | DarkEdgeTV | SIPHO - Aquarium Shenanigans | 2,416 | |
| 47. |  Rai Galilei【NIJISANJI / にじさんじ】 | 【 Sipho 】Rai Galilei's : "Cellular glorious evolution!!"【 NIJISANJI ID】 | 2,359 | |
| 48. |  싸뽀쭈어 | (POE) Legacy of Fresia 2.0 nerfed, but still a pretty decent mapping build! Scavenger Power Sipho... | 2,108 | |
| 49. | Randomise User: The Best Indie Games | SIPHO gameplay: Construct Your Own Killer Fish! | Explore & Build on the Fly! (Early Access game) | 1,770 | Let's Play |
| 50. | Стримы Интроверта | Стало веселей) - Sipho #3 | 1,375 | |
| 51. | SonOfmowgef | Sipho. Part 2. Best laid plans of microbes and men. | 1,015 | |
| 52. | SonOfmowgef | Sipho. Part 3. How does do move good? | 1,005 | |
| 53. | SonOfmowgef | Sipho. Part 1. The 4th most popular Evolution sim?! | 931 | |
| 54. |  WhackyCast | Surviving in Deep Waters! What Creature Am I? - Sipho Gameplay | 865 | |
| 55. | Satan Claus 🎮 PLAY! | СВЕЖИЙ РОГАЛИК, ВДОХНОВЛЕННЫЙ ИГРОЙ "SPORE" | Sipho (Первый взгляд) | 787 | |
| 56. | Frazzz | Sipho Gameplay - Smash Look! | 743 | |
| 57. | FallenShogun Gaming | DNA level of Spore but with actual Gameplay | SIPHO Gameplay | EARLY ACCESS GAMEPLAY | 735 | Let's Play |
| 58. | FallenShogun Gaming | SIPHO Gameplay | The DNA level of Spore but with actual Gameplay | EARLY ACCESS GAMEPLAY | 663 | Let's Play |
| 59. | Jankum | The PUFFER is My New Favorite Part in SIPHO. For Real. | 659 | |
| 60. | Jankum | Trying Every Breed In SIPHO - LIVE | 546 | |
| 61. | FallenShogun Gaming | SIPHO | The DNA level of Spore but with actual Gameplay | ALPHA GAMEPLAY | 509 | Let's Play |
| 62. | Jankum | Creating The ULTIMATE CELL in SIPHO - LIVE | 444 | |
| 63. | valanak | SIPHO ПРОХОЖДЕНИЕ | ДЕЛАЕМ СВОЕ НЕЧТО | 389 | |
| 64. | Raithias c | Make your own Zerg!|Sipho | 371 | |
| 65. | Space Game Junkie | Sipho - Genetically Building the Most Survivable Creature | 315 | |
| 66. | FallenShogun Gaming | Designing Genetic Monstrosities from Spore in SIPHO | 291 | Let's Play |
| 67. | Are0us | Damn Ocean You Scary - Sipho | 272 | |
| 68. |  Haga Hagane | [Sipho] From The Water We Go - Haga Hagane | 200 | |
| 69. | CoalFire | Sipho - Back Into The Depths! - Early Access Episode 1 | 189 | |
| 70. | PlumYeti | Grinder Leech is a bit OP - Sipho | 184 | Let's Play |
| 71. | PlumYeti | Checking out Sipho | 178 | Let's Play |
| 72. | The Indie Buffet | Text Based Choose Your Adventure Roguelike | Upheaval | 173 | |
| 73. |  Şanlı Diyarlar | Küçük Hayatlar - Sipho İnceleme - Nasıl Oynanır - Türkçe | 171 | |
| 74. | Jeux1d100 | [FR Linux] Sipho. Amibe en eau beau bobo | 165 | |
| 75. | SonOfmowgef | Sipho. Part 7. I've got a micro stalker! | 141 | |
| 76. |  Albert.Saavedra.Pickleball | 🦠 SPORE y AGAR.IO en un mismo JUEGO 🦠 || SIPHO || GAMEPLAY ESPAÑOL | 136 | |
| 77. |  Rogue HeavenX | Lets Play Sipho - Ep 3 - Revisit :) | 126 | Let's Play |
| 78. | SonOfmowgef | Sipho. Part 6. I'd be good at this game if I was better at this game. | 126 | |
| 79. | Game Wisdom | Sipho Tries to Evolve Rogue-Like Play | Indie Game Spotlight | 111 | |
| 80. | SonOfmowgef | Sipho. Part 5. It's a thing that tells me things, about things. | 97 | |
| 81. | Regal Dreamer | [01] Sipho - The Poison King | 84 | |
| 82. |  Alley Source | Sipho - Gameplay Pausa Indie | 79 | |
| 83. |  Les chnikos Gaming | [Gameplay] BIENVENUE À PARASITE PARK - Sipho | 76 | |
| 84. | Trailer Vault | Sipho | Gameplay Trailer | 72 | Preview |
| 85. |  Derbaler | S.1#001 Sipho - Gameplay german deutsch lets play Video Game Action Indie All Parts Connected Steam | 68 | |
| 86. | 谜之声 | 【谜之声实况】Sipho 细胞进化大战 汲取之旅 | 67 | |
| 87. |  Liquiix | EP.1 วิวัฒนาการไร้สิ้นสุด?!【Sipho!】 | 57 | |
| 88. |  JustIn Boxing | COMMANDING MINIONS WITH MY VOICE | Warkestra Demo | 57 | |
| 89. | Derbaler | S.1#003 Sipho - Gameplay german deutsch lets play Video Game Action Indie All Parts Connected Steam | 46 | |
| 90. | Regal Dreamer | [02] Sipho - The Bee Movie | 38 | |
| 91. | Liquiix | EP.3 พลังก้ามปู!【Sipho!】 | 38 | |
| 92. | Zero Verse | Sipho - Livestreaming | 36 | |
| 93. | Hixel Bay | Finally, some ranged attacks / Spore-like evolution roguelite / Sipho | 34 | |
| 94. | Vidya Gaem Awards PLUS | /agdg/ Game Trailers - 2018 Vidya Gaem Awards | 32 | Preview |
| 95. | Stashtastique | Sipho Gameplay | 32 | |
| 96. | ハチヤ | 気持ち悪いスイミーみたいな化物を育てて食物連鎖の頂点を目指せ！ 【Sipho】 | 30 | |
| 97. | Derbaler | S.1#002 Sipho - Gameplay german deutsch lets play Video Game Action Indie All Parts Connected Steam | 30 | |
| 98. | Derbaler | S.1#005 Sipho - Gameplay german deutsch lets play Video Game Action Indie All Parts Connected Steam | 28 | |
| 99. | Derbaler | S.1#004 Sipho - Gameplay german deutsch lets play Video Game Action Indie All Parts Connected Steam | 27 | |
| 100. | GogetaSuperx | Sipho gameplay - GogetaSuperx | 21 | |
