| 1. | Scott Manley | Spacechem - Chemistry, In Spaaaccce. | 187 | |
| 2. | Tasselfoot | Electric Box Walkthrough - Candystand | 64 | Walkthrough |
| 3. | Arthur Huynh | SpaceChem - Polar Expedition Achievement Guide + Free TF2 items (Steam Gift Grab) | 60 | Guide |
| 4. | slowbeef | SpaceChem - User-Created Assignment (23/1/50) | 52 | |
| 5. | Szyl | how to get the spacechem items in TF2 2023 | 51 | |
| 6. | Gaming With BenWo0 | Ben's 5K Sub-stravaganza Pizza Party! | 28 | |
| 7. | sprucemooseful | SpaceChem: One Reactor Solution for "No Ordinary Headache" | 26 | |
| 8. | PaV | Five games you've never heard of | 25 | |
| 9. | The Gemsbok | The Atmosphere of SpaceChem | 19 | |
| 10. | slowbeef | SpaceChem: The Toughest Puzzler | 18 | |
| 11. | Anton Petrov | MineTest- review - GAMES IN EDUCATION (Math and more) | 9 | Review |
| 12. | slowbeef | SpaceChem: The Toughest Puzzler (Part 2) | 8 | |
| 13. | TheInvertedShadow | Oh look, I got SpaceChem.wmv | 7 | |
| 14. | Paul Eres | RinkuHero's crazy solution: SpaceChem - It Takes Three (913/1/45) | 6 | |
| 15. | TheInvertedShadow | Do this one, fellas | 6 | |
| 16. | TroZ | SpaceChem - No Thanks Necessary | 6 | |
| 17. | Andrea Rovenski | Play Time -- SpaceChem - Indie Week Part 5 | 4 | |
| 18. | Game Wisdom | Catching up With Zachtronics | Perceptive Podcast, Zach Barth Interview, Developer Interview | 4 | Show |
| 19. | TroZ | SpaceChem - Removing Bonds | 4 | |
| 20. | Bird Catcher | SpaceChem #3 - My name is Bond. Double Bond. | 4 | |
| 21. | Leylite | SpaceChem "Neodymium Magnet" | 4 | |
| 22. | Karsten's Chronicle | SpaceChem - Molecular Foundry (12455/2/96) with commentary | 3 | |
| 23. | cognitiveTrifurcation | The Infodump: Physics Episode 2: Haha Rome Go Brrrrrr | 3 | |
| 24. | Leylite | 2017 SpaceChem Tournament - Round 8 "Noble Fission" Results | 3 | Discussion |
| 25. | Leylite | SpaceChem "Boron Compounds" - 1222/6/141 | 3 | |
| 26. | Outside The Box {The PowerUser's M.M. D.B.} | Spacechem E8 ~ Bad routing | 3 | |
| 27. | Adam Savage’s Tested | App of the Day: Spacechem | 3 | |
| 28. | Leylite | SpaceChem "2-Hexene" | 2 | |
| 29. | duckingcreepers | Wow. Terrible. - Duckingstreamers Ep. 18 (SpaceChem) [1/26/19] | 2 | |
| 30. | R30hedron | Emoticons and Syncs -- SpaceChem (04) | 2 | |
| 31. | R30hedron | Stoichiometry -- SpaceChem (06) | 2 | |
| 32. | Outside The Box {The PowerUser's M.M. D.B.} | Spacechem E4 ~ Production chains | 2 | |
| 33. | TheInvertedShadow | Breaking some bonds | 2 | |
| 34. | R30hedron | Don't Need the Tutorials -- SpaceChem (00) | 2 | |
| 35. | Leylite | Solving SpaceChem - "How Ionic" | 2 | |
| 36. | Leylite | SpaceChem "That's a Relief" | 2 | |
| 37. | Arthur Huynh | SpaceChem Science is an Indoor Activity Ticket | 2 | |
| 38. | it's ok to be stupid | SpaceChem - Removing Bonds (32/1/16) | 2 | |
| 39. | TroZ | SpaceChem - Challenge: In-Place Swap | 2 | |
| 40. | Leylite | SpaceChem "Desperate Measures" - 2460/6/224 | 2 | |
| 41. | Leylite | SpaceChem "Getting Pumped" | 2 | |
| 42. | Karsten's Chronicle | SpaceChem - Falling (2 reactors, with comments) (2338/2/78) | 2 | |
| 43. | Game Wisdom | The Last Call For Zachtronics | Zach Barth Interview, Perceptive Podcast #gamedev #indiedev | 2 | Show |
| 44. | Leylite | SpaceChem Tournament 2014 - Comet Chemistry | 2 | |
| 45. | TroZ | SpaceChem - Nothing Works | 2 | |
| 46. | jbzdarkid | Spacechem any% in 25:14 | 2 | |
| 47. | Outside The Box {The PowerUser's M.M. D.B.} | Spacechem E2 ~ Processing networks | 1 | |
| 48. | Murdoink | SpaceChem - Nothing Works (1768/4/114) | 1 | |
| 49. | The Questing Truck | SpaceChem - No Ordinary Headache (2435/2/77) | 1 | |
| 50. | Leylite | SpaceChem "Symmetry" - 497/1/67 | 1 | |
| 51. | TroZ | SpaceChem - An Introduction to Bonding | 1 | |
| 52. | TroZ | SpaceChem - Molecular Foundry | 1 | |
| 53. | Leylite | SpaceChem "Waste Gas" | 1 | |
| 54. | Leylite | 2017 SpaceChem Tournament - Round 3 "Doping" Results | 1 | Discussion |
| 55. | The Questing Truck | SpaceChem - Under the Ice (638/1/38) | 1 | |
| 56. | Outside The Box {The PowerUser's M.M. D.B.} | Spacechem E5 ~ Potentially unreliable | 1 | |
| 57. | Leylite | SpaceChem "Life: Cytosine" | 1 | |
| 58. | The Questing Truck | SpaceChem - Random Oxides (914/1/46) | 1 | |
| 59. | Outside The Box {The PowerUser's M.M. D.B.} | Spacechem E3 ~ Bepuzzlement | 1 | |
| 60. | MinamiChimaa Ch. 美波チマー | 【SpaceChem】Pyrotechnics | #3 | 1 | |
| 61. | Paul Spooner | SpaceChem - Challenge: KOHCTPYKTOP (3649/5/180) | 1 | |
| 62. | Leylite | SpaceChem "Diels-Alder" | 1 | |
| 63. | R30hedron | It's Too Efficient! -- SpaceChem (02) | 1 | |
| 64. | R30hedron | Nothing Works? It Does Now! -- SpaceChem (01) | 1 | |
| 65. | R30hedron | I Thought It Was Random... -- SpaceChem (03) | 1 | |